Dechlorane Plus and its dechlorinated analogs from an e-waste recycling center in maternal serum and breast milk of women in Wenling, China

Ben, Yujie; Li, Xinghong; Yang, Youlin; Long, Liling; Di, Jun-Ping; Wang, Wenyue; Zhou, Ren-Fang; Xiao, Ke; Zheng, Mei; Tian, Yun; Xu, Xiaobai

doi:10.1016/j.envpol.2012.09.028

Cited by 62 publications

(78 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, these two hypotheses are still needed to be confirmed. DP dechlorination products were commonly reported in biota including human tissues, the levels were generally much lower than those of DP (Ben et al, 2013;Chen et al, 2011Chen et al, , 2013aGuerra et al, 2011;Mo et al, 2013;Muñoz-Arnanz, et al, 2011Peng et al, 2012Peng et al, , 2014Sun et al, 2012;Yan et al, 2012;Zhang et al, 2011b;Zheng et al, 2010Zheng et al, , 2014. However, an extremely high level was observed in a fresh water food web around DP facility in Huai'an, China, where the concentrations of anti-Cl 10 -DP and anti-Cl 11 -DP was 84.4 ng g −1 lw and 1030 ng g −1 lw, respectively .The dechlorinated products of DP in biota were mainly attributed to accumulation from the external habitat environment rather than internal metabolism, although the gender difference observed in some cases suggested that anti-Cl 11 -DP in the human body may be partly formed from in vivo dechlorination of the anti-isomer (Yan et al, 2012).…”

Section: Dp Dechlorinated Analogsmentioning

confidence: 96%

“…Chromatographic separation was usually achieved using capillary gas chromatography (GC) columns with a non-polar stationary phase, such as DB-5MS (De la Hoh et al, 2006;Jia et al, 2011;Ren et al, 2008;Zeng et al, 2014;Zhang et al, 2013;Zheng et al, 2015a), DB-5HT (Muñoz-Arnanz et al, 2011), DB-XLB (Chen et al, 2013a(Chen et al, , 2013bMo et al, 2013;Yan et al, 2012;Zhang et al, 2011b), CP-Sil 13 CB , VF-5MS (Peng et al, , 2014, Rxi-5MS (Qiu and Hites, 2008) and Rtx-1614 (Ben et al, 2013;Peverly et al, 2015). The 15 m and 30 m columns were generally selected.…”

Section: Instrumental Analysis and Quantificationmentioning

confidence: 99%

See 1 more Smart Citation

Sources and environmental behaviors of Dechlorane Plus and related compounds — A review

Wang

Zhang

et al. 2016

Environment International

View full text Add to dashboard Cite

Although Dechlorane Plus (DP) has been used as a polychlorinated flame retardant for almost half a century, its detection in the environment was not reported until 2006. The subsequent intensive research has confirmed its global ubiquity. A few reviews have presented the properties, analytical methods and environmental occurrence of DP and related compounds in the past several years. The present review emphasizes on the environmental behavior of DP isomers which is assessed by the variation of the isomer ratio of DP in various matrices. Other aspects including the analytical methods, emission sources, general environmental occurrence and bioaccumulation of DP are also summarized. In this review, three typical emission sources in the environment are categorized after introducing the measurement method of DP. The temporal-spatial distribution is then evaluated at the global scale, which provides an integrated representation of the environmental occurrence of DP and potential impact on the human health and ecosystems. The variations of DP isomer ratio in various matrices reinforce its source related distribution and their stereoselective bioaccumulation. Thereafter, DP related compounds and dechlorinated analogs are briefly summarized in regards to their occurrence in various matrices, suggesting their ubiquity in the environment and bioavailability. Further studies are required to better assess the exposures and toxicological effects of DP and its analogs. A special concern is the serious contamination in e-waste recycling areas in developing countries, where long-term monitoring data on the association of DP exposure and adverse effects to human health and ecosystems is urgently needed.

show abstract

Section: Dp Dechlorinated Analogsmentioning

confidence: 96%

Section: Instrumental Analysis and Quantificationmentioning

confidence: 99%

Sources and environmental behaviors of Dechlorane Plus and related compounds — A review

Wang

Zhang

et al. 2016

Environment International

View full text Add to dashboard Cite

show abstract

“…In addition, Zheng et al 28 also found relatively higher DP concentration in human hair in e-waste recycling area as well as in indoor dust, suggesting that e-waste recycling activities could cause contamination of DP in the surrounding environment and that dust is one of the major pathways for DP exposure. Recently, Ben et al 29 investigated DP in the human blood and milk from Taizhou area, an e-waste recycling site in China and the results showed that DP levels in long-term residents of the local area (>20 years) were significantly higher than the others (<3 years). To our knowledge, there are no studies reporting on the human exposure to DP during DP manufacturing process.…”

Section: ■ Introductionmentioning

confidence: 99%

Assessment on the Occupational Exposure of Manufacturing Workers to Dechlorane Plus through Blood and Hair Analysis

Zhang¹,

Wang²,

Li³

et al. 2013

Environ. Sci. Technol.

View full text Add to dashboard Cite

Dechlorane Plus (DP), as a widely used flame retardant in different electrical and textile applications, has recently attracted great concern around the world. The present study investigated the DP levels and distribution in human samples from a DP manufacturing plant and a nearby area in east China. The DP concentrations ranged from 89.8 to 2958 ng/g lipid weight in whole blood and 4.08 to 2159 ng/g dry weight in hair. For the workers engaged in DP manufacturing process, their DP levels were significantly higher than those in most of the other two control groups from the nearby area. The values of anti-DP fractional abundance ( f anti ratio) were commonly lower in the human samples from both the manufacturing plant and nearby area compared with those in the commercial products, and excretion as well as biotransformation are possible reasons for stereoselective accumulation of the syn-DP isomer in humans. Furthermore, a significantly positive relationship (p < 0.05) was obtained between (i) the concentrations (and f anti ) in the paired blood and hair samples, indicating a similar distribution pattern of the two DP isomers in the paired samples; (ii) the DP levels in human body and the exposure time (p < 0.05), which suggests that further assessment could be needed to investigate potential long-term risks to the occupational population.

show abstract

“…A detailed description of the sampling area has been published previously. 9 The donors were screened according to their residential location and residential history. All donors are required to be residing in a rural area.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

“…5−8 Newborns will have been exposed to toxicants that could cross the placenta and will be further exposed through breastfeeding. DP and its analogs have recently been detected in human breast milk, 9,10 indicating that newborns will be exposed to DP postnatally. Although DP and its dechlorinated analogs have been found in bird eggs and the transfer of DP from mother to offspring has been studied in wildlife, 4,11,12 information on prenatal exposure to DP and its related compounds in humans is not available.…”

Section: ■ Introductionmentioning

confidence: 99%

Placental Transfer of Dechlorane Plus in Mother–Infant Pairs in an E-Waste Recycling Area (Wenling, China)

Ben

Yang

et al. 2014

Environ. Sci. Technol.

Self Cite

View full text Add to dashboard Cite

It has been reported that breastfeeding can expose newborns to dechlorane plus (DP), but transplacental transfer of DP has not been documented. We measured DP and its dechlorinated analogs in matched maternal blood− placenta−cord blood samples from 72 residents of the e-waste recycling area of Wenling, China. DP was detected in cord sera, indicating the occurrence of prenatal DP exposure and the transfer of DP across the placenta. The concentration ratio in the cord serum and maternal serum was estimated to be 0.45 for syn-DP and 0.35 for anti-DP, indicating the placenta partially limited DP transfer with a greater extent for anti-DP. The DP concentrations in the maternal serum, placenta, and cord serum strongly correlated, indicating that DP could transfer between the tissues. The DP concentrations in the matched samples could be predicted from each other. The anti-DP/ total DP concentration ratios in the placentas and cord sera were significantly different from those in the maternal sera, suggesting that DP stereoselectively bioaccumulates in human tissues. When the congener concentrations of polybrominated diphenyl ethers (PBDEs) were used as control variables, DP and total triiodothyronine concentrations were associated in the sera from mothers who had lived in Wenling for over 20 years.

show abstract

Dechlorane Plus and its dechlorinated analogs from an e-waste recycling center in maternal serum and breast milk of women in Wenling, China

Cited by 62 publications

References 28 publications

Sources and environmental behaviors of Dechlorane Plus and related compounds — A review

Sources and environmental behaviors of Dechlorane Plus and related compounds — A review

Assessment on the Occupational Exposure of Manufacturing Workers to Dechlorane Plus through Blood and Hair Analysis

Placental Transfer of Dechlorane Plus in Mother–Infant Pairs in an E-Waste Recycling Area (Wenling, China)

Contact Info

Product

Resources

About