Decellularized Scaffold-Based Artificial Vascular Patch for Porcine Vascular Repair

Abstract

Vascular transplantation is an effective strategy against cardiovascular diseases (CVD), and artificial vascular patches are of urgent need across the world. In this work, we designed a multifunctional decellularized scaffolds (DCS)-based vascular patch for porcine vascular repair. Ammonium phosphate zwitter-ion (APZI) and poly­(vinyl alcohol) (PVA) hydrogel were coated on the surface of DCS to improve the mechanical properties and biocompatibility of an artificial vascular patch. Then a heparin (Hep)-loaded metal–organic framework (MOF) further decorated the artificial vascular patches to inhibit blood coagulation and promote vascular endothelialization. The obtained artificial vascular patch showed suitable mechanical properties, good biocompatibility, and blood compatibility. In addition, the proliferation and adhesion of endothelial progenitor cells (EPCs) on the surface of artificial vascular patch improved a lot when compared with unmodified PVA/DCS. According to the results of B-ultrasound and CT images, the artificial vascular patch could maintain the patency of the implant site after implanting into the pig carotid artery. The current results solidly support that a MOF-Hep/APZI-PVA/DCS vascular patch would be an excellent vascular replacement material.

Application of metal-organic frameworks-based functional composite scaffolds in tissue engineering

“…M199 loaded in PCL electrospun fibrous scaffolds can maintain long-term NO catalytic activity, significantly promote EC migration, increase the uptake of acetylated low-density lipoprotein (Ac-LDL) and inhibit platelet adhesion and activation ( Figure 6A–C ) [ 208 ]. In recent years, non-copper-based MOFs have been gradually applied in the cardiovascular field [ 209 , 210 ]. The Fe-based MOF MIL-101(Fe) can be used as a mechanical enhancer, sustained-release drug carrier and MRI contrast agent to modify PCL-based vascular scaffolds [ 210 ].…”

“…In recent years, non-copper-based MOFs have been gradually applied in the cardiovascular field [ 209 , 210 ]. The Fe-based MOF MIL-101(Fe) can be used as a mechanical enhancer, sustained-release drug carrier and MRI contrast agent to modify PCL-based vascular scaffolds [ 210 ]. MIL-101 (Fe)-modified artificial vascular patches could inhibit blood coagulation and promote vascular endothelialization [ 210 ].…”

“…The Fe-based MOF MIL-101(Fe) can be used as a mechanical enhancer, sustained-release drug carrier and MRI contrast agent to modify PCL-based vascular scaffolds [ 210 ]. MIL-101 (Fe)-modified artificial vascular patches could inhibit blood coagulation and promote vascular endothelialization [ 210 ]. ZIF-8 nanoparticles have been used to deliver carbon monoxide and coated with HA-CAG peptide to enhance its bioactivity [ 209 ] ( Figure 6D ).…”

Rapid-Test Kit for Cardiac Troponin I: A Reliable Enzyme-Linked-Immuno-Substrate-Assay-Based Biosensor for Daily-Use Naked-Eye Detection and Pharmacokinetic Studies for Myocardial Infarction in Cardiovascular Disease

“…In cardiovascular diseases (CVDs), plaque accumulates in the coronary artery and affects blood flow, − resulting in a lack of oxygen or nutrition in the heart that can lead to death. The American Heart Association annually releases statistical reports on heart disease, stroke, and cardiovascular risk factors, and considerable research efforts are devoted to CVD. , This focus includes artificial polymer bypass graft transplants, ,− stent material innovations, antithrombosis medicine studies, ,− tissue engineering for artificial vascular grafts, ,, tissue repair medicine for ischemia, ,− and creating biomarkers for detection. ,,, …”