Decellularized kidney scaffold-mediated renal regeneration

Yu, Yaling; Shao, Yingkuan; Ding, Yu; Lin, Kuan‐Yu; Chen, B.; Zhang, H.Z.; Zhao, Lina; Wang, Z.B.; Zhang, J.S.; Tang, Maolin; Mei, Jin

doi:10.1016/j.biomaterials.2014.04.074

Cited by 97 publications

(82 citation statements)

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“…For example, cells use compartmentalization to control various biochemical reactions in space and time [91], and the way in which cells migrate is directed by the physical aspects of their surroundings, and particularly the properties of the ECM [92]. Notably, the surprising properties of biomaterials largely result from their surfaces as well as their sophisticated hierarchical bulk structures [93,94]. For example, scaffolding biomaterials must possess biocompatible (and ideally antibacterial) surfaces to reduce or eliminate undesirable host responses, mimic the structure of the target living organism in one to three dimensions, exhibit interconnected porosity to support cell/tissue penetration and be capable of resorption over time to create space for new tissues [18,45,46].…”

Section: Biomaterials For Tissue Engineeringmentioning

confidence: 99%

“…In this respect, polymer brushes with various structures and chemistries, as well as diverse brush-based strategies, which are both passive and bioactive, may be utilized for biomaterial modification. In particular, these features may make the material surfaces biocompatible and non-fouling, which passively prevents subsequent undesirable host responses [93]. In addition, fiber-assisted molding (FAM) has been shown to be a simple and robust method to create biomimetic 3D surfaces with controllable curvature and a helical twist.…”

Section: Biomaterials For Tissue Engineeringmentioning

confidence: 99%

“…The post-processed matrix may enable efficient cell reseeding and offer biomechanical strength and structural integrity for new tissue formation. For example, retrograde or antegrade perfusion has been applied as a method for whole-organ decellularization, in which the 3D architecture of the organ is largely preserved [93,486]. The decellularized matrices maintain the shape of the original organ and can be either directly used as scaffolding materials in tissue engineering approaches for organ regeneration or made into different types ( e.g.…”

Section: Human Tissue Ecm-based Biomaterialsmentioning

confidence: 99%

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Advancing biomaterials of human origin for tissue engineering

Chen

Liu

2016

Progress in Polymer Science

925

513

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Biomaterials have played an increasingly prominent role in the success of biomedical devices and in the development of tissue engineering, which seeks to unlock the regenerative potential innate to human tissues/organs in a state of deterioration and to restore or reestablish normal bodily function. Advances in our understanding of regenerative biomaterials and their roles in new tissue formation can potentially open a new frontier in the fast-growing field of regenerative medicine. Taking inspiration from the role and multi-component construction of native extracellular matrices (ECMs) for cell accommodation, the synthetic biomaterials produced today routinely incorporate biologically active components to define an artificial in vivo milieu with complex and dynamic interactions that foster and regulate stem cells, similar to the events occurring in a natural cellular microenvironment. The range and degree of biomaterial sophistication have also dramatically increased as more knowledge has accumulated through materials science, matrix biology and tissue engineering. However, achieving clinical translation and commercial success requires regenerative biomaterials to be not only efficacious and safe but also cost-effective and convenient for use and production. Utilizing biomaterials of human origin as building blocks for therapeutic purposes has provided a facilitated approach that closely mimics the critical aspects of natural tissue with regard to its physical and chemical properties for the orchestration of wound healing and tissue regeneration. In addition to directly using tissue transfers and transplants for repair, new applications of human-derived biomaterials are now focusing on the use of naturally occurring biomacromolecules, decellularized ECM scaffolds and autologous preparations rich in growth factors/non-expanded stem cells to either target acceleration/magnification of the body's own repair capacity or use nature's paradigms to create new tissues for restoration. In particular, there is increasing interest in separating ECMs into simplified functional domains and/or biopolymeric assemblies so that these components/constituents can be discretely exploited and manipulated for the production of bioscaffolds and new biomimetic biomaterials. Here, following an overview of tissue auto-/allo-transplantation, we discuss the recent trends and advances as well as the challenges and future directions in the evolution and application of human-derived biomaterials for reconstructive surgery and tissue engineering. In particular, we focus on an exploration of the structural, mechanical, biochemical and biological information present in native human tissue for bioengineering applications and to provide inspiration for the design of future biomaterials.

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Section: Biomaterials For Tissue Engineeringmentioning

confidence: 99%

Section: Biomaterials For Tissue Engineeringmentioning

confidence: 99%

Section: Human Tissue Ecm-based Biomaterialsmentioning

confidence: 99%

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Advancing biomaterials of human origin for tissue engineering

Chen

Liu

2016

Progress in Polymer Science

925

513

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“…Decellularised tissue is the most widely explored 3D kidney TE method, due to its physical and mechanical properties (Nakayama et al 2010;Uzarski et al 2014;Yu et al 2014;He et al 2016). Using this technique, a rat kidney model has been shown to produce urine in vitro and in vivo; however, barriers for TE kidneys still remain including optimisation of cell seeding processes, the scaling up of existing strategies, and availability of a feasible cell source (Song et al 2013).…”

Section: Introductionmentioning

confidence: 99%

The effect of electrospun polycaprolactone scaffold morphology on human kidney epithelial cells

2017

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There is a pressing need for further advancement in tissue engineering of functional organs with a view to providing a more clinically relevant model for drug development and reduce the dependence on organ donation. Polymer based scaffolds, such as polycaprolactone (PCL), have been highlighted as a potential avenue for tissue engineered kidneys, but there is little investigation down this stream.Focus within kidney tissue engineering has been on 2-dimensional cell culture and decellularised tissue. Electrospun polymer scaffolds can be created with a variety of fibre diameters and have shown a great potential in many areas. The variation in morphology of tissue engineering scaffold has been shown to effect the way cells behave and integrate. In this study we examined the cellular response to scaffold architecture of novel electrospun scaffold for kidney tissue engineering. Fibre diameters of 1.10±0.16 µm and 4.49±0.47 µm were used with 3 distinct scaffold architectures. Traditional random fibres were spun onto a mandrel rotating at 250 rpm, aligned at 1800 rpm with novel cryogenic fibres spun onto a mandrel loaded with dry ice rotating at 250 rpm. Human kidney epithelial cells were grown for 1 and 2 weeks. Fibre morphology had no effect of cell viability in scaffolds with a large fibre diameter but significant differences were seen in smaller fibres. Fibre diameter had a significant effect in aligned and cryogenic scaffold. Imaging detailed the differences in cell attachment due to scaffold differences. These results show that architecture of the scaffold has a profound effect on kidney cells; whether that is effects of fibre diameter on the cell attachment and viability or the effect of fibre arrangement on the distribution of cells and their alignment with fibres. Results demonstrate that PCL scaffolds have the capability to maintain kidney cells life and should be investigated further as a potential scaffold in kidney tissue engineering.

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“…Such studies should include a number of pre-clinical studies on model creation of kidney diseases and application of tissue-engineered kidney constructs [102]; more sophisticated approaches on partial and whole kidney implantation dealing with immunological issues; innervation of the implant; and renal physiology.…”

Section: Concluding Remarks and Future Perspectivementioning

confidence: 99%