Decellularized aorta of fetal pigs as a potential scaffold for small diameter tissue engineered vascular graft

Li, Guofeng; Zhong, He; Yang, Daping; Han, Xuefeng; Guo, Tao; Hao, Chenguang; Ma, Hui; Nie, Chunlei

doi:10.1097/00029330-200808010-00013

Cited by 26 publications

(19 citation statements)

References 33 publications

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“…Other decellularized tubular conduits have been investigated for vascular tissue engineering. Specifically, aorta [158, 159], umbilical arteries [4], saphenous vein [46], ureter [160, 161], and small intestinal submucosa (SIS) [162, 163] to name a few. Cryolife, Inc, have constructed a vascular graft from decellularized bovine tissue that shows high patency in a canine model, with host cell repopulation of the prosthesis [164].…”

Section: Evolving Concepts and Current Status Of Tebv Technologymentioning

confidence: 99%

Tissue Engineering of Blood Vessels: Functional Requirements, Progress, and Future Challenges

Kumar

Brewster

Caves

et al. 2011

Cardiovasc Eng Tech

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Vascular disease results in the decreased utility and decreased availability of autologus vascular tissue for small diameter (< 6 mm) vessel replacements. While synthetic polymer alternatives to date have failed to meet the performance of autogenous conduits, tissue-engineered replacement vessels represent an ideal solution to this clinical problem. Ongoing progress requires combined approaches from biomaterials science, cell biology, and translational medicine to develop feasible solutions with the requisite mechanical support, a non-fouling surface for blood flow, and tissue regeneration. Over the past two decades interest in blood vessel tissue engineering has soared on a global scale, resulting in the first clinical implants of multiple technologies, steady progress with several other systems, and critical lessons-learned. This review will highlight the current inadequacies of autologus and synthetic grafts, the engineering requirements for implantation of tissue-engineered grafts, and the current status of tissue-engineered blood vessel research.

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Section: Evolving Concepts and Current Status Of Tebv Technologymentioning

confidence: 99%

Tissue Engineering of Blood Vessels: Functional Requirements, Progress, and Future Challenges

Kumar

Brewster

Caves

et al. 2011

Cardiovasc Eng Tech

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“…Liu et al . () tested fetal pig aortas decellularized with trypsin and EDTA; the burst pressures were similar to those of native fetal aortae.…”

Section: Influence Of Different Decellularizing Methods On the Mechanmentioning

confidence: 99%

Decellularized biological matrices: an interesting approach for cardiovascular tissue repair and regeneration

Boccafoschi

Botta

Fusaro

et al. 2015

J Tissue Eng Regen Med

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The repair and replacement of blood vessels is one of the most challenging topics for biomedical research. Autologous vessels are preferred as graft materials, but they still have many issues to overcome: for instance, they need multiple surgical procedures and often patients may not have healthy and surgically valuable arteries useful as an autograft. A tissue-engineering approach is widely desirable to generate biological vascular prostheses. Recently, decellularization of native tissue has gained significant attention in the biomedical research field. This method is used to obtain biological scaffolds that are expected to maintain the complex three-dimensional structure of the extracellular matrix, preserving the biomechanical properties of the native tissues. The decellularizing methods and the biomechanical characteristics of these products are presented in this review. Decellularization of biological matrices induces the loss of major histocompatibility complex (MHC), which is expected to promote an immunological response by the host. All the studies showed that decellularized biomaterials possess adequate properties for xenografting. Concerning their mechanical properties, several studies have demonstrated that, although chemical decellularization methods do not affect the scaffolds' mechanical properties, these materials can be modified through different treatments in order to provide the desired mechanical characteristics, depending on the specific application. A short overview of legislative issues concerning the use of decellularized substitutes and future perspectives in surgical applications is also presented. Copyright © 2015 John Wiley & Sons, Ltd.

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“…Selective tissue isolation experiments confirmed that the material properties of large arteries are predominantly (95%) determined by their extracellular matrix components (Schaner et al 2004, Roy et al 2005, Kassab 2006, Liu et al 2008. All of the sequential segments analysed demonstrated the classic non-linear stress-strain relationship indicative of vascular walls comprised of a hybrid mixture of extracellular matrix components (wavy collagen and pre-stretched elastin) (Purinya andKasyanov 1980, Gupta andKasyanov 1997).…”

mentioning

confidence: 87%

Toward organ printing: Design characteristics, virtual modelling and physical prototyping vascular segments of kidney arterial tree

Kasyanov

Brakke

Vilbrandt³

et al. 2011

Virtual and Physical Prototyping

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Decellularized aorta of fetal pigs as a potential scaffold for small diameter tissue engineered vascular graft

Cited by 26 publications

References 33 publications

Tissue Engineering of Blood Vessels: Functional Requirements, Progress, and Future Challenges

Tissue Engineering of Blood Vessels: Functional Requirements, Progress, and Future Challenges

Decellularized biological matrices: an interesting approach for cardiovascular tissue repair and regeneration

Toward organ printing: Design characteristics, virtual modelling and physical prototyping vascular segments of kidney arterial tree

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