“…Benzonase) and endonucleases (e.g. DNase) are commonly used to break the nucleotide bonds and remove remnant DNA [ 20 , 21 , 27 ]. Different tissue or organ types require different decellularization protocols, depending on their architecture and composition of ECM, and need to be optimized for respective tissue or organ before their intended use [ 24 , 28 ].…”