2003
DOI: 10.1002/jcp.10369
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Decapeptide with fibroblast growth factor (FGF)‐5 partial sequence inhibits hair growth suppressing activity of FGF‐5

Abstract: Earlier studies demonstrated that knock-out of fibroblast growth factor-5 gene (Fgf-5) prolonged anagen VI phase of hair cycle, resulting long hairs in the mice. We showed the activities on hair growth of the two Fgf-5 gene products, one of which, FGF-5 suppressed hair growth by inhibiting anagen proceeding and inducing the transition from anagen to catagen, and FGF-5S, a shorter polypeptide with FGF-5-antagonizing activity translated from alternatively spliced mRNA, suppressed this activity of FGF-5. As the r… Show more

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Cited by 28 publications
(18 citation statements)
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References 48 publications
(60 reference statements)
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“…We first assessed the ability of test compounds to inhibit FGF5-induced proliferation of the engineered FGF receptor 1-expressing BaF3 cell line 27. The BaF3 cell line used in the study is a cell line engineered to express FGFR1c, originally used to study the splice variant of FGF5 known as FGF5s 26. The BaF3 cell lineage is IL-3 dependent and responds to the presence of IL-3 by proliferating.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…We first assessed the ability of test compounds to inhibit FGF5-induced proliferation of the engineered FGF receptor 1-expressing BaF3 cell line 27. The BaF3 cell line used in the study is a cell line engineered to express FGFR1c, originally used to study the splice variant of FGF5 known as FGF5s 26. The BaF3 cell lineage is IL-3 dependent and responds to the presence of IL-3 by proliferating.…”
Section: Resultsmentioning
confidence: 99%
“…Alternate mRNA splicing of FGF5 results in the translation of long (FGF5) and short (FGF5S) isoforms, which are known to act in concert. FGF5S acts as an antagonist to the catagen-inducing effect of FGF5,25 and in this vein there is potential for exogenous inhibitors of FGF5 to promote hair growth, as demonstrated by Ito et al26…”
Section: Introductionmentioning
confidence: 94%
“…To list only a few well-studied examples from the murine system, WNT-b-catenin-Lef 1 signalling, noggin, and STAT3 drive telogen follicles into anagen, and Shh, HGF, and FGF7 (KGF) further promote this process (Ellis et al, 2003;Oro and Higgins, 2003;Van Mater et al, 2003;Celso et al, 2004). BMP4 and 17-bestradiol arrest the follicle in telogen Guha et al, 2004); IGF-1, HGF, GDNF, and VEGF prolong the duration of anagen (Su et al, 1999;Lindner et al, 2000;Mecklenburg et al, 2000), while FGF5, TGFb1, TGFb2, the neurotrophins NT-3, NT-4, and BDNF, as well as p75NTR signalling, induce catagen (Botchkarev et al, 1998b(Botchkarev et al, , 2004Soma et al, 1998Soma et al, , 2002Foitzik et al, 2000;Ito et al, 2003) (Fig. 5).…”
Section: Molecular Players In Murine Hair Cycle Controlmentioning
confidence: 99%
“…Such peptides possess a higher stability and specificity, are less expensive than PRP and can be easily included in a topical formulation. These benefits have been shown in many applications, ranging from skin rejuvenation [37,38] to wound-healing [38] and hair growth [39][40][41][42][43][44].…”
Section: Discussionmentioning
confidence: 99%