Decapentaplegic: A gene complex affecting morphogenesis in Drosophila melanogaster

Spencer, Forrest; Hoffmann, F. M.; Gelbart, William M.

doi:10.1016/0092-8674(82)90199-4

Cited by 336 publications

(225 citation statements)

References 20 publications

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“…The location and connectivity of apical protrusions (columnar cells to squamous cells) and lateral protrusions (columnar cells to columnar cells) makes them well suited to play a role in the exchange of such signaling molecules. Dpp is a member of the transforming growth factor-␤ family of secreted molecules that is important for the growth and patterning of wing imaginal discs (Spencer et al, 1982;Padgett et al, 1987;Capdevila and Guerrero, 1994;Zecca et al, 1995) and that has been shown to be present in the lumen between columnar cells and squamous cells (Gibson et al, 2002). To test whether apical or lateral protrusions could mediate the communication between cells by displaying a receptor for Dpp, we expressed a GFP-tagged version of the Dpp receptor Thickveins (Tkv; Hsiung et al, 2005) in the dorsal compartment of columnar wing imaginal disc cells.…”

Section: Tkv-gfp Identifies Apical and Basal Protrusions Of Columnar mentioning

confidence: 99%

Apical and lateral cell protrusions interconnect epithelial cells in live Drosophila wing imaginal discs

Demontis

Dahmann

2007

Developmental Dynamics

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Section: Tkv-gfp Identifies Apical and Basal Protrusions Of Columnar mentioning

confidence: 99%

Apical and lateral cell protrusions interconnect epithelial cells in live Drosophila wing imaginal discs

Demontis

Dahmann

2007

Developmental Dynamics

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“…During the larval stages, dpp expression in specific patterns in the imaginal disks is required for normal proliferation and/or viability of the disk epithelial cells (Bryant, 1988). Reduction in the level of dpp expression leads to the absence of specific adult cuticular structures along the distal to proximal axis of adult appendages (Spencer et al, 1982).…”

Section: Introductionmentioning

confidence: 99%

Embryonic expression patterns of the drosophila decapentaplegic gene: Separate regulatory elements control blastoderm expression and lateral ectodermal expression

Jackson

Hoffmann

1994

Developmental Dynamics

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Patterns of decapentaplegic (dpp) transcripts derived from the intact gene were compared to the patterns of transcripts generated by partial dpp transgenes in Drosophila embryos. Sequences closest to the dpp coding regions, the dpp hin region, were sufficient to express ZacZ-tagged mRNA in patterns indistinguishable from the patterns of endogenous dpp expression in the dorsal and terminal cells at the blastoderm stage, in the dorsal ectoderm during germ band elongation, and in narrow stripes of ectodermal cells along the dorsal edge of the ectoderm and at the boundary between the lateral and ventral neurogenic regions during germ band shortening. The latter pattern of expression responded to the segment polarity genes naked and wingless. However, these dpp sequences were not sufficient to drive ZucZ-tagged mRNA expression in other cells normally expressing dpp, including cells in the gnathal segments, the clypeolabrum, the foregut, the midgut visceral mesoderm, and the hindgut. Two separate regulatory regions were found in the dpp hin region. A 479 bp region upstream of the promoter was necessary for the segmented pattern of expression in the lateral ectoderm and for expression in the midgut endoderm. Cis-acting elements in the 2 kbp second intron directed expression in the dorsal and terminal regions of the blastoderm, acted on a heterologous promoter, the P-element promoter, and responded to pattern information derived from the maternal effect dorsal/ventral patterning genes. 0 1994 Wiley-Liss, Inc.

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“…An interesting corollary to add to these is the fact that TGF-β is activated by the serine protease, plasmin (50) . The receptor for TGF-β is not known, but one of the members of this family of growth factors appear to be responsible for establishing the dorsal axis in Xenopus embryos (51) , while another, decapentaplegic gene product, is active later in the establishment of the dorsal axis in Drosophila (52,53) .…”

Section: Actin and The Specification Of The Dorsal-ventral Axismentioning

confidence: 99%

Actin in the Drosophila embryo: Is there a relationship to developmental cue localization?

Bearer¹

1991

BioEssays

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SummaryRecent genetic manipulations have revealed that the cytoplasm of the early Drosophila embryo contains localized information that specifies the future embryonic axes. It is the restricted distribution or activity of particular gene products, either messenger RNA or protein, that is crucial for this specification. While some of the genes responsible for this information have been sequenced and the nature and distribution of their products examined, it is not known how this localization is established or maintained. The actin-based cytoskeleton is a likely candidate for the formation, of a cytomatrix that would allow such distributions and yet no direct evidence has yet been found that implicates actin in positional cue localization. In this review I summarize what is known about actin filament behavior in Drosophila embryos and compare it to the distribution of positional cues. My purpose is to juxtapose these two bodies of information such that the relationship between them may be revealed.

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Decapentaplegic: A gene complex affecting morphogenesis in Drosophila melanogaster

Cited by 336 publications

References 20 publications

Apical and lateral cell protrusions interconnect epithelial cells in live Drosophila wing imaginal discs

Apical and lateral cell protrusions interconnect epithelial cells in live Drosophila wing imaginal discs

Embryonic expression patterns of the drosophila decapentaplegic gene: Separate regulatory elements control blastoderm expression and lateral ectodermal expression

Actin in the Drosophila embryo: Is there a relationship to developmental cue localization?

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