Decanal Protects against UVB-Induced Photoaging in Human Dermal Fibroblasts via the cAMP Pathway

Kang, Won Jun; Choi, Dawoon

doi:10.3390/nu12051214

Cited by 21 publications

(17 citation statements)

References 39 publications

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“…Matrix metalloproteinases (MMPs) are known as collagenase and the UVB-induced expressions of MMP1, 3, and 9 are considered as the dominant cause of decreased collagen in skin ( Kang et al, 2020 ). In cultured dermal fibroblasts, the transcriptional levels of different MMP isoforms, i.e., MMP1a, MMP3, and MMP9, were increased markedly by few folds under UVB irradiation ( Figure 4 ).…”

Section: Resultsmentioning

confidence: 99%

Capsaicin, a Phytochemical From Chili Pepper, Alleviates the Ultraviolet Irradiation-Induced Decline of Collagen in Dermal Fibroblast via Blocking the Generation of Reactive Oxygen Species

Bai

Guo

et al. 2022

Front. Pharmacol.

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Capsaicin, a major ingredient in chili pepper, has broad pharmaceutical applications, including relieving pain, anti-inflammation, and treating psoriasis. In dermatological biology, capsaicin has been shown to prevent the ultraviolet (UV)-induced melanogenesis via TRPV1 receptor. To strengthen the roles of capsaicin in skin function, the damaged skin, triggered by exposure to UV, was reversed by capsaicin in both in vitro and in vivo models. In cultured dermal fibroblasts, the exposure to UV induced a decrease of collagen synthesis and increases expression of matrix metalloproteinases (MMPs), generation of reactive oxygen species (ROS), and phosphorylation of Erk and c-Jun, and these events subsequently led to skin damage. However, the UV-mediated damages could be reversed by pre-treatment with capsaicin in a dose-dependent manner. The effect of capsaicin in blocking the UV-mediated collagen synthesis was mediated by reducing generation of ROS in dermal fibroblasts, instead of the receptor for capsaicin. Hence, capsaicin has high potential value in applying as an agent for anti-skin aging in dermatology.

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Section: Resultsmentioning

confidence: 99%

Capsaicin, a Phytochemical From Chili Pepper, Alleviates the Ultraviolet Irradiation-Induced Decline of Collagen in Dermal Fibroblast via Blocking the Generation of Reactive Oxygen Species

Bai

Guo

et al. 2022

Front. Pharmacol.

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“…Although hyaluronic acid makes up only ~0.1–0.3% of dry skin weight, it can bind up to 1000 times its weight of water [ 44 , 45 , 46 ]. Hyaluronic acid is produced in the plasma membrane by HAS1–3; HAS2 appears to be the dominant isoform in dermal fibroblasts because of the extent to which HAS2 upregulation correlates with an increase in hyaluronic acid secretion [ 47 , 48 , 49 ]. In the present study, β-ionone treatment attenuated dexamethasone-induced suppression of type I procollagen genes and of the HAS2 gene and increased both procollagen and hyaluronic acid contents in human dermal fibroblasts.…”

Section: Discussionmentioning

confidence: 99%

β-Ionone Attenuates Dexamethasone-Induced Suppression of Collagen and Hyaluronic Acid Synthesis in Human Dermal Fibroblasts

et al. 2021

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Stress is a major contributing factor of skin aging, which is clinically characterized by wrinkles, loss of elasticity, and dryness. In particular, glucocorticoids are generally considered key hormones for promoting stress-induced skin aging through binding to glucocorticoid receptors (GRs). In this work, we aimed to investigate whether β-ionone (a compound occurring in various foods such as carrots and almonds) attenuates dexamethasone-induced suppression of collagen and hyaluronic acid synthesis in human dermal fibroblasts, and to explore the mechanisms involved. We found that β-ionone promoted collagen production dose-dependently and increased mRNA expression levels, including collagen type I α 1 chain (COL1A1) and COL1A2 in dexamethasone-treated human dermal fibroblasts. It also raised hyaluronic acid synthase mRNA expression and hyaluronic acid levels. Notably, β-ionone inhibited cortisol binding to GR, subsequent dexamethasone-induced GR signaling, and the expression of several GR target genes. Our results reveal the strong potential of β-ionone for preventing stress-induced skin aging and suggest that its effects are related to the inhibition of GR signaling in human dermal fibroblasts.

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“…We found that carvone treatment activated the cAMP signaling pathway (Figure 3), which is known to be upregulated in a relatively short time in response to various stimuli [32][33][34]. Although the mechanisms by which carvone raises cAMP concentrations are unknown, it is worth noting that carvone has been identified as a ligand of numerous olfactory receptors (ORs; e.g., OR1A1, OR8B3, and OR5P3, which constitute the largest subfamily of G-protein-coupled receptors) in each OR-transfected HEK293 cell line [35,36].…”

Section: Discussionmentioning

confidence: 90%

Carvone Decreases Melanin Content by Inhibiting Melanoma Cell Proliferation via the Cyclic Adenosine Monophosphate (cAMP) Pathway

2020

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Melanin, which determines the color of the skin and hair, is initially synthesized to protect the skin from ultraviolet light; however, excessive melanin pigmentation caused by abnormal cell proliferation can result in various melanocytic lesions. Cyclic adenosine monophosphate (cAMP) is known to regulate cell cycle progression and consequently to inhibit the division of abnormally proliferating cells. In this work, we aimed to test whether carvone, a scent compound from plants, inhibits proliferation and subsequently reduces melanin content of melanoma cells and to determine whether its beneficial effects are mediated by the cAMP pathway. We found that carvone decreases melanin content and inhibits melanoma cell proliferation in a concentration-dependent manner. Meanwhile, it inhibited the activation of cell cycle-associated proteins such as cyclin-dependent kinase 1 (CDK1). Of note, the beneficial effects of carvone were abrogated by cAMP inhibition. Our findings indicate potential benefits of carvone for the treatment of melanomas and presumably other hyperpigmentation-related dermatological disorders such as melasmas, lentigines, and excessive freckles.

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Decanal Protects against UVB-Induced Photoaging in Human Dermal Fibroblasts via the cAMP Pathway

Cited by 21 publications

References 39 publications

Capsaicin, a Phytochemical From Chili Pepper, Alleviates the Ultraviolet Irradiation-Induced Decline of Collagen in Dermal Fibroblast via Blocking the Generation of Reactive Oxygen Species

Capsaicin, a Phytochemical From Chili Pepper, Alleviates the Ultraviolet Irradiation-Induced Decline of Collagen in Dermal Fibroblast via Blocking the Generation of Reactive Oxygen Species

β-Ionone Attenuates Dexamethasone-Induced Suppression of Collagen and Hyaluronic Acid Synthesis in Human Dermal Fibroblasts

Carvone Decreases Melanin Content by Inhibiting Melanoma Cell Proliferation via the Cyclic Adenosine Monophosphate (cAMP) Pathway

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