Capsaicin, a Phytochemical From Chili Pepper, Alleviates the Ultraviolet Irradiation-Induced Decline of Collagen in Dermal Fibroblast via Blocking the Generation of Reactive Oxygen Species

Wu, Qiyun; Bai, Panzhu; Guo, Hongsheng; Guo, Maggie Suisui; Xia, Yingjie; Xia, Yiteng; Gao, Xiong; Wang, Xiaoyang; Wu, Jiahui; Dong, Tina Tingxia; Tsim, Karl Wah-Keung

doi:10.3389/fphar.2022.872912

Cited by 7 publications

(4 citation statements)

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“…monocytes and macrophages, express a7 nAChR in controlling skin homeostasis [23]. During UV-induced photoaging or photo-dermatoses, the application of a7 nAChR agonists has been reported to reduce the production of inflammatory cytokines, as well as the ROS-mediated collagen degradation in keratinocytes and skin fibroblasts [16,24,25]. The current results supported that a7 nAChR can regulate skin pigmentation, in which the activation of a7 nAChR potentiates phagocytic activity, or melanosome uptake, of keratinocytes.…”

Section: Discussionsupporting

confidence: 75%

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The UV‐induced uptake of melanosome by skin keratinocyte is triggered by α7 nicotinic acetylcholine receptor‐mediated phagocytosis

Guo

Dong

et al. 2022

The FEBS Journal

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The melanosome is an organelle that produces melanin for skin pigmentation, which is synthesized by epidermal melanocytes, subsequently transported and internalized by epidermal keratinocytes. Exposure to ultraviolet (UV) from sunlight radiation is a major stimulator of melanosome uptake by keratinocytes. Acetylcholine (ACh) is known to be released by keratinocytes under UV exposure, which regulates melanin production in melanocytes by participating in which has been named as ‘skin synapse’. Here, the role of cholinergic molecules, i.e. ACh and α7 nicotinic acetylcholine receptor (nAChR), in regulating melanosome uptake through phagocytosis by keratinocytes was illustrated. In cultured keratinocytes (HaCaT cells), the fluorescent beads at different sizes imitating melanosomes, or melanosomes, were phagocytosed under UV exposure. The UV‐induced phagocytosis in keratinocytes was markedly increased by applied ACh, an acetylcholinesterase (AChE) inhibitor or an α7 nAChR agonist. By contrast, the antagonist of α7 nAChR was able to fully block the UV‐induced phagocytosis, suggesting the role of α7 nAChR in this event. The intracellular Ca++ mobilization was triggered by UV exposure, accounting for the initiation of phagocytosis. The blockage of UV‐mediated Ca++ mobilization, triggered by BAPTA‐AM or α7 nAChR antagonist, resulted in a complete termination of phagocytosis. Besides, the phosphorylation of cofilin, as well as expression and activation of RhoA, accounting for phagocytosis was induced by UV exposure: the phosphorylation was blocked by BAPTA‐AM or α7 nAChR antagonist. The result suggests that the cholinergic system, especially α7 nAChR, is playing a regulatory role in modulating melanosome uptake in keratinocytes being induced by UV exposure.

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Section: Discussionsupporting

confidence: 75%

“…The exposure to UVB can cause the formation of reactive oxygen species (ROS) in keratinocytes [15,16]. The relevance of ROS formation and UVB-induced phagocytosis was examined.…”

Section: Uvb-induced Ros Formation Has No Role In Phagocytosismentioning

confidence: 99%

The UV‐induced uptake of melanosome by skin keratinocyte is triggered by α7 nicotinic acetylcholine receptor‐mediated phagocytosis

Guo

Dong

et al. 2022

The FEBS Journal

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“…A study has revealed that capsaicin boosted collagen synthesis in cultured dermal fibroblasts via extracellular signal-regulated kinases (Erk)/c-Jun-mediated MMP signaling. Moreover, the application of low-dose capsaicin on the shaved mouse dorsal skins alleviated the UV-induced reduction of collagen ( Wu et al, 2022 ). In addition, baicalein suppressed MMP-1 expression by activating the TRPV1-Ca 2+ -ERK pathway in UVB-irradiated human dermal fibroblasts ( Huang et al, 2019 ).…”

Section: The Role Of Trpv1 In Skin Agingmentioning

confidence: 99%

TRPV1: A promising therapeutic target for skin aging and inflammatory skin diseases

Xiao

Sun²,

Zhao³

et al. 2023

Front. Pharmacol.

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TRPV1 is a non-selective channel receptor widely expressed in skin tissues, including keratinocytes, peripheral sensory nerve fibers and immune cells. It is activated by a variety of exogenous or endogenous inflammatory mediators, triggering neuropeptide release and neurogenic inflammatory response. Previous studies have shown that TRPV1 is closely related to the occurrence and/or development of skin aging and various chronic inflammatory skin diseases, such as psoriasis, atopic dermatitis, rosacea, herpes zoster, allergic contact dermatitis and prurigo nodularis. This review summarizes the structure of the TRPV1 channel and discusses the expression of TRPV1 in the skin as well as its role of TRPV1 in skin aging and inflammatory skin diseases.

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“…Understanding capsaicin research from global perspectives over an extended time is crucial. Although several studies have been published on capsaicin applications, bioactivities, and many other capsaicin-related topics (33)(34)(35), none of these studies explored the scientometric approach to critically assess its progress and current direction in scientific research. Bibliometrics is a valuable tool for evaluating research trends within a subject area, thus providing insight into extensively researched themes and identifying research needs to inform action (36).…”

Section: Introductionmentioning

confidence: 99%

Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer

et al. 2022

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Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is one of the most important natural products in the genus Capsicum. Due to its numerous biological effects, there has been extensive and increasing research interest in capsaicin, resulting in increased scientific publications in recent years. Therefore, an in-depth bibliometric analysis of published literature on capsaicin from 2001 to 2021 was performed to assess the global research status, thematic and emerging areas, and potential insights into future research. Furthermore, recent research advances of capsaicin and its combination therapy on human cancer as well as their potential mechanisms of action were described. In the last two decades, research outputs on capsaicin have increased by an estimated 18% per year and were dominated by research articles at 93% of the 3753 assessed literature. In addition, anti-cancer/pharmacokinetics, cytotoxicity, in vivo neurological and pain research studies were the keyword clusters generated and designated as thematic domains for capsaicin research. It was evident that the United States, China, and Japan accounted for about 42% of 3753 publications that met the inclusion criteria. Also, visibly dominant collaboration nodes and networks with most of the other identified countries were established. Assessment of the eligible literature revealed that the potential of capsaicin for mitigating cancer mainly entailed its chemo-preventive effects, which were often linked to its ability to exert multi-biological effects such as anti-mutagenic, antioxidant and anti-inflammatory activities. However, clinical studies were limited, which may be related to some of the inherent challenges associated with capsaicin in the limited clinical trials. This review presents a novel approach to visualizing information about capsaicin research and a comprehensive perspective on the therapeutic significance and applications of capsaicin in the treatment of human cancer.

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Capsaicin, a Phytochemical From Chili Pepper, Alleviates the Ultraviolet Irradiation-Induced Decline of Collagen in Dermal Fibroblast via Blocking the Generation of Reactive Oxygen Species

Cited by 7 publications

References 50 publications

The UV‐induced uptake of melanosome by skin keratinocyte is triggered by α7 nicotinic acetylcholine receptor‐mediated phagocytosis

The UV‐induced uptake of melanosome by skin keratinocyte is triggered by α7 nicotinic acetylcholine receptor‐mediated phagocytosis

TRPV1: A promising therapeutic target for skin aging and inflammatory skin diseases

Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer

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