Debut of inflammatory bowel disease associated to ixekizumab in patient with moderate, difficult-to-manage psoriasis

Gallego, Esther Merino; Torres, Katherine Gómez; Amate, Eva Martínez

doi:10.1016/j.gastre.2020.04.004

Cited by 3 publications

(7 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A total of 29 studies were identified in the published literature, including 25 case reports ( Ehrlich et al, 2018 ; Grimaux et al, 2018 ; Paul et al, 2018 ; Wang et al, 2018 ; Achufusi et al, 2019 ; Grossberg, 2019 ; Haidari et al, 2019 ; Johnston and Veettil, 2019 ; Philipose et al, 2019 ; Rodriguez et al, 2019 ; Shimizu et al, 2019 ; Smith et al, 2019 ; Darch et al, 2020 ; Fieldhouse et al, 2020 ; Marin et al, 2020 ; Merino Gallego et al, 2020 ; Nazarian et al, 2020 ; Ali et al, 2021 ; Mu et al, 2021 ; Obeidat and Murakami, 2021 ; Ma et al, 2022 ; Sykaras et al, 2022 ; Kukol et al, 2019 ; Nallapeta et al, 2019 ; Sethi et al, 2019 ) and 4 case series ( Fobelo et al, 2018 ; Shukla et al, 2018 ; Vernero et al, 2019 ; Lee et al, 2020 ); a total of 34 cases raised evidence of IBD occurrence during therapy with SEC (27 cases, 79.4%) and IXE (7 cases, 20.6%). Characteristics of the included cases are presented in Table 4 .…”

Section: Resultsmentioning

confidence: 99%

IL-17 inhibitor-associated inflammatory bowel disease: A study based on literature and database analysis

Deng

Wang

et al. 2023

Front. Pharmacol.

View full text Add to dashboard Cite

Objective: Few real-world studies have shown clear association between interleukin (IL)-17 inhibitors and inflammatory bowel disease (IBD) onset. This study investigated the reporting prevalence and evaluated the clinical features and management of IL-17 inhibitor-related IBD events.Methods: We used the US FDA Adverse Event Reporting System database and retrieved data, from 2015 to 2022, on IL-17 inhibitors to identify gastrointestinal inflammatory events and conduct disproportionality analyses by estimating the reporting odds ratios (RORs) and corresponding 95% confidence intervals (CIs). Furthermore, case reports and case series, from 2015 to 30 November 2022, on IBD induced by IL-17 inhibitors were collected for retrospective analysis.Results: A total of 388 cases of primary suspected IL-17 inhibitor-associated gastrointestinal events were reported (268 IBD and 120 colitis), including 348 cases involving secukinumab (SEC), 36 cases involving ixekizumab (IXE), and 4 cases involving brodalumab (BRO). Statistically significant reporting rates of total IBD events were observed for SEC and IXE (ROR = 2.13, 95% CI [1.96-2.30] and ROR = 2.79, 95% CI [2.39-3.27], respectively), whereas BRO did not trigger a safety signal. Twenty-nine studies, which included 34 cases, showed evidence of IBD, following SEC (79.4%) and IXE (20.6%) treatment. The median age was 42 years; typical initial symptoms included diarrhea (90.9%), abdominal pain (57.6%), bloody diarrhea (51.5%), and fever (36.4%). The median time to onset of IBD symptoms was 2.9 months. Some cases were accompanied by elevated white blood cell (WBC) count (87.5%), erythrocyte sedimentation rate (ESR; 85.7%), C-reactive protein (CRP; 100%), and fecal calprotectin (FC; 100%). Cessation of IL-17 inhibitors plus treatment with corticosteroids and TNF antagonists, as either monotherapy or in combination, could lead to complete clinical remission. The median time to remission after IL-17 inhibitor discontinuation was 4 weeks.Conclusion: IL-17 inhibitor treatment is associated with exacerbation and new onset of IBD and colitis. Obtaining a detailed patient history before initiation of treatment and monitoring gastrointestinal symptoms and intestinal inflammatory biomarkers during IL-17 inhibitor treatment is important for safe use of these drugs.

show abstract

Section: Resultsmentioning

confidence: 99%

IL-17 inhibitor-associated inflammatory bowel disease: A study based on literature and database analysis

Deng

Wang

et al. 2023

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…In 2020, Merino Gallego E, Torres Gomez K, and Martinez Amate E presented the case of a 42-year-old male with severe inverse psoriasis under biologic therapy with ixekizumab [ 63 ]. The patient had, as well, a personal history of sleep apnea/hypopnea syndrome and smoking [ 63 ]. Two weeks after being initiated on ixekizumab, the patient developed fever, abdominal pain, and diarrhea [ 63 ].…”

Section: Discussionmentioning

confidence: 99%

“…The patient had, as well, a personal history of sleep apnea/hypopnea syndrome and smoking [ 63 ]. Two weeks after being initiated on ixekizumab, the patient developed fever, abdominal pain, and diarrhea [ 63 ]. The patient was admitted to the Gastroenterology Department where further investigations were carried out [ 63 ].…”

Section: Discussionmentioning

confidence: 99%

“…Two weeks after being initiated on ixekizumab, the patient developed fever, abdominal pain, and diarrhea [ 63 ]. The patient was admitted to the Gastroenterology Department where further investigations were carried out [ 63 ]. Microbiological studies of the feces were negative, as well as the blood cultures [ 63 ].…”

Section: Discussionmentioning

confidence: 99%

“…The patient was admitted to the Gastroenterology Department where further investigations were carried out [ 63 ]. Microbiological studies of the feces were negative, as well as the blood cultures [ 63 ]. Colonoscopy revealed acute inflammation with aphtoid erosions, fibrinous patchy ulcers from the rectum to the cecum and terminal ileum [ 63 ].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

An Insight on the Possible Association between Inflammatory Bowel Disease and Biologic Therapy with IL-17 Inhibitors in Psoriasis Patients

Orzan,

Țieranu,

Olteanu

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

Psoriasis is a chronic, inflammatory, multisystemic disease which affects approximately 2–3% of the population globally, whose onset is triggered by genetic and environmental factors which activate both dendritic cells and keratinocytes, resulting in the production of proinflammatory cytokines such as tumor necrosis factor alpha, interleukin 17, interleukin 23, interleukin 22, and interleukin 1β. An in-depth understanding of the pathophysiology of psoriasis led to significant advances in the development of safe and efficient novel therapeutic options, with four classes of biologic therapy being approved for the management of moderate to severe psoriasis: tumor necrosis factor alpha inhibitors, interleukin 23 inhibitors, anti-interleukin 12/23 agents, anti-interleukin 17 agents, as well as small-molecule inhibitors, such as apremilast. Psoriasis is associated with comorbid conditions, namely psoriatic arthritis, cardiovascular disease, metabolic syndrome, psychiatric disorders, malignancy, as well as inflammatory bowel disease. For patients affected by both psoriasis and inflammatory bowel disease, there is a strong recommendation to avoid IL-17 inhibitors since they may play a part in the exacerbation of the gastrointestinal disease. Our aim was to perform a thorough literature review regarding the development of inflammatory bowel disease lesions in psoriasis patients treated with IL-17 inhibitors, along with a case presentation to emphasize the need for close follow-up of these patients.

show abstract

Ixekizumab

2021

Reactions Weekly

View full text Add to dashboard Cite

Debut of inflammatory bowel disease associated to ixekizumab in patient with moderate, difficult-to-manage psoriasis

Cited by 3 publications

References 4 publications

IL-17 inhibitor-associated inflammatory bowel disease: A study based on literature and database analysis

IL-17 inhibitor-associated inflammatory bowel disease: A study based on literature and database analysis

An Insight on the Possible Association between Inflammatory Bowel Disease and Biologic Therapy with IL-17 Inhibitors in Psoriasis Patients

Ixekizumab

Contact Info

Product

Resources

About