Debridement of Diabetic Foot Ulcers

Dayya, David; O'Neill, Owen; Huedo‐Medina, Tania B.; Habib, Nusrat; Moore, J.; Iyer, Kartik K.

doi:10.1089/wound.2021.0016

Cited by 68 publications

(65 citation statements)

References 68 publications

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“…Small and unmyelinated nerve fibers responsible for conducting afferent sensory perception, like C-type fibers, are the first to be damaged, resulting in tissue damage due to poor perception of trauma and/or mechanical stress. Thus, the relatively minor damage will continue to accumulate and result in a progressively worsening wound with difficulty in healing[ 33 ].…”

Section: Risk Factors For Dfumentioning

confidence: 99%

Diabetic foot ulcers: Classification, risk factors and management

Wang¹,

Yuan²,

Xu³

et al. 2022

World J Diabetes

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Diabetic foot ulceration is a devastating complication of diabetes that is associated with infection, amputation, and death, and is affecting increasing numbers of patients with diabetes mellitus. The pathogenesis of foot ulcers is complex, and different factors play major roles in different stages. The refractory nature of foot ulcer is reflected in that even after healing there is still a high recurrence rate and amputation rate, which means that management and nursing plans need to be considered carefully. The importance of establishment of measures for prevention and management of DFU has been emphasized. Therefore, a validated and appropriate DFU classification matching the progression is necessary for clinical diagnosis and management. In the first part of this review, we list several commonly used classification systems and describe their application conditions, scope, strengths, and limitations; in the second part, we briefly introduce the common risk factors for DFU, such as neuropathy, peripheral artery disease, foot deformities, diabetes complications, and obesity. Focusing on the relationship between the risk factors and DFU progression may facilitate prevention and timely management; in the last part, we emphasize the importance of preventive education, characterize several of the most frequently used management approaches, including glycemic control, exercise, offloading, and infection control, and call for taking into account and weighing the quality of life during the formulation of treatment plans. Multidisciplinary intervention and management of diabetic foot ulcers (DFUs) based on the effective and systematic combination of these three components will contribute to the prevention and treatment of DFUs, and improve their prognosis.

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Section: Risk Factors For Dfumentioning

confidence: 99%

Diabetic foot ulcers: Classification, risk factors and management

Wang¹,

Yuan²,

Xu³

et al. 2022

World J Diabetes

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“…The above observations made in the course of the analysis unambiguously draw attention to the continuation of training and paying attention to the above method, which is becoming more and more appreciated in Poland, especially at the times of pandemic COVID 19/SARS-CoV-2. Taking into account the increasing number of patients with wounds, the difficulties related to the availability of hospital care, home-based and outpatient wound therapy with MDT is gaining new meaning, and may indicate new directions of clinicians’ activities when combined with the subsequent use of NPWT (Negative Pressure Wound Therapy) [ 18 , 19 , 20 , 21 ]. The 2020 guidelines for the care and treatment of pressure ulcers of the Polish Wound Treatment Society (PTLR) recommend MDT in the treatment of pressure ulcers [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Perception and Readiness to Undertake Maggot Debridement Therapy with the Use of Lucilia sericata Larvae in the Group of Nurses

Bazaliński

Przybek-Mita

Ścisło

et al. 2022

IJERPH

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The sight and smell of larvae in the wound may cause negative visual and olfactory impressions in sensitive individuals because of decaying body parts, carrion, and suffering. However, Maggot Debridement Therapy (MDT) is highly effective, safe, and cheap in wound healing and tissue revitalization for both the patient and health systems. The aim of the study was to assess the readiness to undertake MDT in a group of qualified nurses who perform therapeutic procedures in patients treated for chronic wounds. A diagnostic survey was used. The research tool was a scientific research protocol consisting of three questionnaires (sociodemographics, MDT perception questionnaire, pictures of wounds for visual assessment). The study included 290 nurses; the mean age was over 42.6 ± 9.9 years, and the median was 44 years. The perception and readiness to implement the method in the tested sample is at the average (standard) level. The image of maggots in the wound causes negative emotions among medical personnel. The higher the knowledge of the MDT method, the greater the motivation to implement it in practice.

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“…Debridement is the process of removal of necrotic, infected tissue leaving behind healthy tissue. 46 There are various types of debridement methods such as surgery, enzymatic, biological, and autolytic debridement that can be used in wound healing. 47 In the surgical approach, scalpels are used to remove dead tissue effectively, while in the enzymatic debridement method, necrotic tissue is removed using enzymatic agents.…”

Section: Available Treatment Optionsmentioning

confidence: 99%

“…Debridement is the process of removal of necrotic, infected tissue leaving behind healthy tissue . There are various types of debridement methods such as surgery, enzymatic, biological, and autolytic debridement that can be used in wound healing .…”

Section: Available Treatment Optionsmentioning

confidence: 99%

Exploration of Lipid-Based Nanocarriers as Drug Delivery Systems in Diabetic Foot Ulcer

2022

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Diabetes mellitus is a chronic manifestation characterized by high levels of glucose in the blood resulting in several complications including diabetic wounds and ulcers, which predominantly require a longer duration of treatment and adversely affect the quality of life of the patients. Nanotechnology-based therapeutics (both intrinsic and extrinsic types) have emerged as a promising treatment in diabetic foot ulcer/chronic wounds owing to their unique characteristics and specific functional properties. In this review, we have focused on the significance of the use of lipids in the healing of diabetic ulcers, their interaction with the injured skin, and recent trends in lipid-based nanocarriers for the healing of diabetic wounds. Lipid nanocarriers are also being investigated for gene therapy in diabetic wound healing to encapsulate nucleic acids such as siRNA and miRNA, which could silence the expression of inflammatory cytokines overexpressed in chronic wounds. Additionally, these are also being explored for encapsulating proteins, peptides, growth factors, and other biological genetic material as therapeutic agents. Lipid-based nanocarriers encompassing a wide variety of carriers such as liposomes, niosomes, ethosomes, solid lipid nanoparticles, and lipidoid nanoparticles that are explored for the treatment of foot ulcers supplemented with relevant research studies have been discussed in the present review. Lipid-based nanodrug delivery systems have demonstrated promising wound healing potential, particularly in diabetic conditions due to the enhanced efficacy of the entrapped active molecules.

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Debridement of Diabetic Foot Ulcers

Cited by 68 publications

References 68 publications

Diabetic foot ulcers: Classification, risk factors and management

Diabetic foot ulcers: Classification, risk factors and management

Perception and Readiness to Undertake Maggot Debridement Therapy with the Use of Lucilia sericata Larvae in the Group of Nurses

Exploration of Lipid-Based Nanocarriers as Drug Delivery Systems in Diabetic Foot Ulcer

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