Deaths from asthma in New Zealand.

Sears, Malcolm R.; Rea, Harold; Fenwick, J; Beaglehole, Robert; Gillies, Alastair J.; Holst, P E; O'Donnell, T V; Rothwell, Rebecca; Sutherland, David

doi:10.1136/adc.61.1.6

Cited by 67 publications

(17 citation statements)

References 11 publications

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“…Psychological distress in children is associated with asthma that is more difficult to manage [4] , with increased frequency and length of hospital admissions [5] and with functional disability [6] . Similar studies linking psychological morbidity to asthma mortality in children have been conducted in New Zealand [3] , and the United States [2] , and in adults in England [7] . In addition, the presence of chronic stressors leads to more acute and severe asthma attacks [8,9] .…”

Section: Introductionmentioning

confidence: 99%

“…Epidemiological studies have shown that the mental health of asthmatic children is an important predictor of asthma morbidity [1] and is linked to asthma mortality [2,3] . Psychological distress in children is associated with asthma that is more difficult to manage [4] , with increased frequency and length of hospital admissions [5] and with functional disability [6] .…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Early-Life Stress on Airway Inflammation in Adult Mice

Vig

Gordon²,

Thébaud³

et al. 2010

Neuroimmunomodulation

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Background/Aims: Neonatal stress induces permanent physiological changes that may influence the immune system. Early-life stress increases asthma disease severity in children. We investigated the effects of early-life stress on allergic airway inflammation using a murine model of asthma coupled to maternal separation as an early-life stress stimulus. Methods: Maternally separated (MS) and unseparated control (CON) mice were sensitized with ovalbumin (OVA) beginning at day 31 after birth. Results: Challenging mice with OVA increased airway hyperresponsiveness (AHR) and the number of inflammatory cells recovered in the bronchoalveolar lavage (BAL), compared to saline-challenged mice. Challenging MS mice with OVA resulted in less total inflammatory cells, eosinophils, interferon-γ, and interleukin-4 in BAL compared to CON mice. However, MS mice challenged with OVA exhibited AHR similar to CON mice challenged with OVA. In contrast, an enhanced stress protocol (MS+) involving removal of pups from their home cages following the removal of the dam resulted in inflammatory cell accumulation and cytokine levels in the BAL similar to CON mice and higher than MS mice. Conclusions: These findings indicate that the effect of early-life psychological factors on the development of airway inflammatory diseases such as asthma is very complex and depends on the quality of the psychological stress stimulus.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Effect of Early-Life Stress on Airway Inflammation in Adult Mice

Vig

Gordon²,

Thébaud³

et al. 2010

Neuroimmunomodulation

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“…Sears and co-workers were at the forefront of the second debate on deaths of asthmatic children [3,4]. This was initially attributed to fenoterol (SABA) [5], and then to an inappropriate management of patients, including the lack of inhaled corticosteroid (ICS) use [6].…”

Section: -Agonistsmentioning

confidence: 99%

Safety of 2-agonists: a 50-year debate closed?

Bousquet

Bourdin

Demoly

2013

European Respiratory Journal

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“…Guidelines prepared in Australia and New Zealand were among the first asthma guidelines, probably because of the asthma death epidemic of the 1980s (74). These guidelines were based on the opinion of experts and their goal was to reduce asthma deaths and morbidity (21).…”

Section: Regulatory Authoritiesmentioning

confidence: 99%

GINA guidelines on asthma and beyond^*

Bousquet

Clark

Hurd³

et al. 2007

Allergy

282

248

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Clinical guidelines are systematically developed statements designed to help practitioners and patients make decisions regarding the appropriate health care for specific circumstances. Guidelines are based on the scientific evidence on therapeutic interventions. The first asthma guidelines were published in the mid 1980s when asthma became a recognized public health problem in many countries. The Global Initiative on Asthma (GINA) was launched in 1995 as a collaborative effort between the NHLBI and the World Health Organization (WHO). The first edition was opinion‐based but updates were evidence‐based. A new update of the GINA guidelines was recently available and it is based on the control of the disease. Asthma guidelines are prepared to stimulate the implementation of practical guidelines in order to reduce the global burden of asthma. Although asthma guidelines may not be perfect, they appear to be the best vehicle available to assist primary care physicians and patients to receive the best possible care of asthma.

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Deaths from asthma in New Zealand.

Cited by 67 publications

References 11 publications

The Effect of Early-Life Stress on Airway Inflammation in Adult Mice

The Effect of Early-Life Stress on Airway Inflammation in Adult Mice

Safety of 2-agonists: a 50-year debate closed?

GINA guidelines on asthma and beyond^*

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Deaths from asthma in New Zealand.

Cited by 67 publications

References 11 publications

The Effect of Early-Life Stress on Airway Inflammation in Adult Mice

The Effect of Early-Life Stress on Airway Inflammation in Adult Mice

Safety of 2-agonists: a 50-year debate closed?

GINA guidelines on asthma and beyond*

Contact Info

Product

Resources

About

GINA guidelines on asthma and beyond^*