Death From Renal Anoxia After Myanesin Anesthesia

Hewer, T F; Woolmer, Ronald

doi:10.1016/s0140-6736(47)90917-3

Cited by 17 publications

(4 citation statements)

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“…It had a spell of popularity as a relaxant some twenty years ago but was rejected primarily because of the toxicity of its solvent (Stephen and Chandy, 1947) which was mainly ethylene glycol. This was both haemolytic (Pugh and Enderby, 1947) and nephrotoxic (Hewer and Woolmer, 1947;Goodier and Goodlast, 1949) when injected intravenously. Diazepam for injection is dissolved in a solvent whose toxicity has been studied in experimental animals and found to have none of the ill-effect associated with ethylene glycol.…”

mentioning

confidence: 95%

Diazepam (Valium) as a Muscle Relaxant During General Anaesthesia: A Pilot Study

Hunter¹

1967

British Journal of Anaesthesia

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Diazepam (Valium) was given to 13 patients during nitrous oxide, oxygen and halothane anaesthesia. Abdominal relaxation was not regularly produced and the amount of tubocurarine required subsequently to produce relaxation was the same as required in patients who had not had diazepam. The drug produced central respiratory depression affecting tidal volume only. It tended to lower the blood pressure.

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confidence: 95%

Diazepam (Valium) as a Muscle Relaxant During General Anaesthesia: A Pilot Study

Hunter¹

1967

British Journal of Anaesthesia

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“…The side effects eliminated Myanesin more or less from medical use. (Pugh and Enderby, 1947 ;Armstrong-Davison, et al, 1949;Hewer and Woolmer, 1947;Lancet, Editorial, 1948;Noble, 1948;Goodier and Goodhart, 1949).…”

Section: History Of the Centrally-actingmentioning

confidence: 99%

“…Because of its safe relaxing effect on the abdominal muscles, the muscle relaxant has been used for gynecological examinations in women (Schwarz, 1959). Obstetricians have taken advantage of this relaxation in childbirth (Bertolotti et al, 1955;Dieke, 1954;Heyn and Beierle, 1954).…”

Section: Glyceryl Guaiacolate In Gynecology and Obstetricsmentioning

confidence: 99%

Glyceryl Guaiacolate: a Centrally Acting Muscle Relaxant

Funk

1970

Equine Veterinary Journal

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Summary A review of the history of centrally‐acting muscle relaxants has been given. The centrally‐acting muscle relaxant glyceryl guaiacolate has been used extensively in continental Europe and, within recent years, has attracted the attention of North American workers. The pharmacological properties of the drug have been described. Glyceryl guaiacolate has been used in humans as well as in domestic and small experimental animals. A detailed description of its indications has been given. These include the fields of short and long term relaxation, tetanus treatment, anaesthesia, gynaecology, obstetrics and neurology. Résumé On passe en revue l'historique des relaxants musculaires à action centrale. Le gaiacolate de glycerol, relaxant d'action centrale, a été utilisé largement en Europe continentale et, depuis quelques années, a attiré l'attention des chercheurs Nord Américains. Les propriètés pharmacologiques de la substance sont décrites. Le gaiacolate de glycerol a été utilisé tant chez l'Homme que chez les animaux domestiques et chez les animaux de laboratoire. Une description détaillée de ses applications est donnée: relaxation de courte ou de longue durée, traitement du tetanos, anesthésie, gynécologie, obstétrique et neurologie. Zusammenfassung Der Autor gibt zuerst eine Literaturübersicht über zentralwirkende Muskelrelaxantien. Das zentrale Angreifen von Glyceringuaiacolat hat im kontinentalen Europa eine weite Verbreitung und in den letzten Jahren auch die Aufmerksamkeit nordamerikanischer Bearbeiter erfahren. Die pharmakologischen Eigenschaften des Medikaments werden beschrieben. Glyceringuaiacolat ist sowohl beim Menschen als auch beim Haustier und bei kleinen Labortieren angewendet worden. Eine detaillierte Beschreibung seiner Indikationen wird angeführt. Die Indikationen umfassen: Kurz‐ und Langzeitrelaxation, Tetanusbehandlung, Narkose, Gynaekologie, Geburtshilfe und Neurologie. Sumario Un repaso en la historia de las drogas musculo relajantes es expuesto. El gliceryl‐guayacolato como relajante muscular ha sido utilizado extensamente en el continenete Europeo y dentro, de los ultimos años ha atraido la atencíon de los investigadores Norteamericanos. Las propiedades farmacológicas de la drogas son descritas. El Gliceryl‐guayacolato ha sido aplicado a humanos asi como a los animales domesticos y animales de laboratorio. Se dan indicaciones detalladas para su utilizacíon. Esto abarca los campos de larga y corta duracíon de relajacíon, tratamiento para el tétanos, anestesia, ginecologia obstetricia y neurologia.

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“…The plasma haemoglobin results are not detailed, but the authors state that the maximum observed values did not exceed the human renal threshold for haemoglobin (100 mg per cent). Mephenesin is not favoured in anaesthetic practice in Britain on account of its haemolytic effects, which have been blamed for fatalities (Pugh and Enderby, 1947;Hewer and Woolmer, 1947) and for the occurrence of thrombophlebitis (Gray, 1948). Guaiacol glycerol ether is, however, apparently widely and successfully used on the continent of Europe, in anaesthetic practice as well as in the treatment of tetanus (Frey and Kirchner, 1959;Hodum, 1960;Mohacsi and Kosa, 1962).…”

mentioning

confidence: 99%

Observations on the Haemolytic Activity of Guaiacol Glycerol Ether

Mostert

Metz

1963

British Journal of Anaesthesia

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The in vivo and in vitro haemolytic activity of guaiacol glycerol ether has been investigated. Intravenous injections in concentrations of 12.5 per cent or greater produced intravascular haemolysis. The haemolysis produced was not related to the speed of injection. In vitro studies with concentrations of guaiacol glycerol ether confirmed that the critical concentration for the production of haemolysis was 12.5 per cent. Guaiacol glycerol ether has approximately one-twentieth the haemolytic activity of ortho-toluol glycerol ether (mephenesin, Myanesin).

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Death From Renal Anoxia After Myanesin Anesthesia

Cited by 17 publications

References 1 publication

Diazepam (Valium) as a Muscle Relaxant During General Anaesthesia: A Pilot Study

Diazepam (Valium) as a Muscle Relaxant During General Anaesthesia: A Pilot Study

Glyceryl Guaiacolate: a Centrally Acting Muscle Relaxant

Observations on the Haemolytic Activity of Guaiacol Glycerol Ether

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