Death due to baclofen and dipyrone ingestion

Death of an Alcohol-Dependent Patient following Intentional Drug Intoxication: Implication of Baclofen?

“…Therefore, our patient exhibited clinical evidence compatible with baclofen intoxication and died despite haemodialysis having been started to compensate for renal failure and to accelerate drug elimination, as reported previously for the management of overdoses [15,20]. To the best of our knowledge, only 1 death was reported after baclofen intoxication since the year 2000: a 56-year-old man having taken a supposed dose of 2,000 mg in association with many other drugs [12]. In addition, during the last 13 years, only 1 case of overdose was reported in an alcohol-dependent patient treated daily with 450 mg of baclofen for his addiction and suffering from chronic renal failure [20].…”

“…Baclofen overdose or intoxication has been widely described in the last decade, especially for suicide purposes in patients suffering from spastic disorders [11,12,13,14,15,16]. The suspected ingested dose of the drug was reported to range from 150 to 2,000 mg.…”

“…The suspected ingested dose of the drug was reported to range from 150 to 2,000 mg. However, only 1 death was reported of a patient having taken 2,000 mg of baclofen in association with dipyrone, oxybutynin, terazosin, acetylsalicylic acid, defibrotide and laxatives [12]. The national survey performed between 2003 and 2007 by the French Poison Information and Toxicovigilance Centres [17] concluded that a supposed ingested dose of baclofen higher than 150, 300 and 1,250 mg could be related to a serious, very serious and fatal intoxication, respectively.…”

Suicide by Multidrug Ingestion

“…The minimum lethal dose of metamizole is about 5 g, 8 and severe intoxication with pyrazolones is quite a rare event. 15,16 Desalkylflurazepam, trazodone, metamizole, and pridinol were also found in gastric contents, probably trapped by AC. AC is usually clinically employed to entrap drugs in acute intoxications 17 because the surface of its particles adsorbs drugs and other chemical substances, preventing the systemic absorption; being a physical bond, substances' desorption can be possible.…”

Lethal intoxication with baclofen

“…В случаях смертельных отравлений концентрация баклофена в сыворотке крови может достигать 17 мкг/мл, а в моче 760 мкг/мл [4,5].…”