A method of identification and quantitative determination of baclofen in blood by HPLC with mass spectrometry detection has been developed. It is characterized by high sensitivity, specificity, linearity, accuracy, reproducibility, and a low detection for quantitative determination. The method has been used for diagnostics of acute baclofen poisoning in patients.
Разработана методика качественного и количественного определения баклофена методом ВЭЖХ с УФ-детектором. Подобраны условия для наибольшей чувствительности определения баклофена методом ВЭЖХ. Наиболее оптимальным вариантом определения баклофена методом ВЭЖХ на неполярных колонках является использование 10 мМ раствора триэтиламина в качестве водного компонента подвижной фазы.
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