Death as a Result of an Adverse Reaction from Nalidixic Acid

Frazer, Marilee; Gault, Robert H.

doi:10.1520/jfs11126j

Cited by 4 publications

(1 citation statement)

References 6 publications

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“…For nalidixic acid, a chemically related compound introduced into the chemotherapy of urinary infections some 20 years ago, a similar broad speetrum of CNS related side effeets has also been described. Confusional states, depression, hallucinations, and, in one case, a psychotic reaetion and seizures resulting in the sudden death of a 27year-old patient were reported (Frazer et al, 1986). For pipemidic acid, rosoxacin and oxolinic acid, three other quinolone derivatives, psychotoxic side efTeets have also been observed.…”

Section: Introductionmentioning

confidence: 90%

Psychotoxic Effects of Ofloxacin

Zaudig¹,

Bose²,

Weber³

et al. 1989

Pharmacopsychiatry

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Two cases of organic psychosis, induced by the new chemotherapeutic agent ofloxacin (Tarivid), are described. According to DSM-III-R and ICD 10 (draft, 1987) both cases present as different, yet well-defined diagnostic categories: the new diagnostic systems appear to be superior and markedly more differentiated than ICD-9, since they provide a more exact and comprehensive description and more specific diagnostic allocation, especially in substance-specific syndromes. The possible involvement of GABAergic and monaminergic mechanisms in this psychotic symptomatology and their relationship to hypersynchronous states are discussed in detail.

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Section: Introductionmentioning

confidence: 90%

Psychotoxic Effects of Ofloxacin

Zaudig¹,

Bose²,

Weber³

et al. 1989

Pharmacopsychiatry

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Psychopathologische Syndrome unter Behandlung mit Gyrasehemmern

Hollweg¹,

Kapfhammer²,

Krupinski³

et al. 1997

Der Nervenarzt

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Psychopathological and neurological adverse drug reactions (ADR) have been repeatedly reported during treatment with gyrase inhibitors (fluorquinolones). Results of earlier studies indicated a high risk for ADR especially in the elderly with high dosage medication, psychiatric history and renal dysfunction. The pathophysiological mechanisms involved in the development of adverse CNS effects are not completely understood. GABA-ergic and monoaminergic mechanisms might play a major part. In a retrospective study conducted by the authors 4189 reports of consultant psychiatric examinations were analyzed. In 29 patients the suspicion of psychopathological ADR during treatment with ofloxacin or ciprofloxacin was documented. Psychopathological findings included delirious states, paranoid, depressive and manic syndromes, agitation, sleep disturbances, sopor and stupor. In elderly patients delirious and paranoid syndromes were predominant, whereas affective disturbances occurred more often in younger patients. In most cases multiple morbidity, liver or kidney diseases, simultaneous treatment with other antibiotics and immunosuppressants, former psychiatric disorders or psychosocial stress factors were present. The results of the study, methodological problems, aspects of risk analysis and implications for medical treatment are discussed.

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The proconvulsive activity of quinolone antibiotics in an animal model

Williams

Helton

1991

Toxicology Letters

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Death as a Result of an Adverse Reaction from Nalidixic Acid

Cited by 4 publications

References 6 publications

Psychotoxic Effects of Ofloxacin

Psychotoxic Effects of Ofloxacin

Psychopathologische Syndrome unter Behandlung mit Gyrasehemmern

The proconvulsive activity of quinolone antibiotics in an animal model

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