Psychopathological and neurological adverse drug reactions (ADR) have been repeatedly reported during treatment with gyrase inhibitors (fluorquinolones). Results of earlier studies indicated a high risk for ADR especially in the elderly with high dosage medication, psychiatric history and renal dysfunction. The pathophysiological mechanisms involved in the development of adverse CNS effects are not completely understood. GABA-ergic and monoaminergic mechanisms might play a major part. In a retrospective study conducted by the authors 4189 reports of consultant psychiatric examinations were analyzed. In 29 patients the suspicion of psychopathological ADR during treatment with ofloxacin or ciprofloxacin was documented. Psychopathological findings included delirious states, paranoid, depressive and manic syndromes, agitation, sleep disturbances, sopor and stupor. In elderly patients delirious and paranoid syndromes were predominant, whereas affective disturbances occurred more often in younger patients. In most cases multiple morbidity, liver or kidney diseases, simultaneous treatment with other antibiotics and immunosuppressants, former psychiatric disorders or psychosocial stress factors were present. The results of the study, methodological problems, aspects of risk analysis and implications for medical treatment are discussed.
§ 217 StGB-Kindestötung, ein nicht mehr zeitgemäßer Paragraph? Forensische Aspekte zur geplanten Reform des § 217 StGB Zusammenfassung: Die gepl ante Streichung des § 217 StGB (Kindest öt un g) wa r Anlaß. die fo ren sische Relevanz dieses Paragraph en für das Einzugsg ebi et des Inst it uts für Rechtsm edizin der Universität Münch en zu übe rprüfen. Die Auswertung der Obd ukt ionen (1989-1994) ergab. daß es sich um ein se ltenes Delikt hande lt, das jedoc h gan z er heb liche strafrechtliche Konsequ enzen zur Folge ha t , wen n nicht die Vo raussetzungen der de rze it gü ltigen Fassung des § 217 (Töt ung des nicht ehe liche n Ki ndes-in od er gleich na ch der Geburt) erfüllt sind. Die Mot ivlage der Täterinnen sowi e psychodyna mische Gesichtsp un kt e eine r verd rän gten Schwangerschaft werden skizziert.
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