De novo Renal Cell Carcinoma in a Kidney Allograft 13 Years after Transplantation: A Case Report and Review of the Literature

Zavos, G.; Kakisis, John D.; Bokos, John; Pappas, Paris; Boletis, John; Kostakis, A.

doi:10.1159/000099354

Cited by 16 publications

(9 citation statements)

References 18 publications

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“…In a retrospective analysis, Leveridge et al [6] reported 45 RCCs in 3,568 recipients who had renal transplant over a period of 43 years; 39 patients had RCC in the native kidney, while 8 were diagnosed with RCC in renal allograft. The majority of renal allograft tumours are diagnosed incidentally when a biopsy or radiological investigations are performed for other clinical indications [10]. The interval between transplantation and allograft tumour diagnosis ranges between 2 and 258 months (mean 56); early detected tumours most likely represent donor-derived tumours [11, 12].…”

Section: Discussionmentioning

confidence: 99%

Incidental Eosinophilic Chromophobe Renal Cell Carcinoma in Renal Allograft

Alharbi

Turki

Aloudah

et al. 2017

Case Reports in Transplantation

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The incidence of renal cell carcinoma (RCC) in renal allograft in transplant recipients is 0.22–0.25%. De novo clear cell, papillary, and chromophobe RCCs and RCCs with sarcomatoid differentiation originating in renal allograft have been reported. Routine surveillance for graft tumours is not routinely practiced and these tumours are commonly asymptomatic and incidentally discovered. We describe a case of incidental, eosinophilic chromophobe RCC in a 31-year-old, long-term renal transplant male recipient, who presented with acute gastroenteritis 11 years after transplantation. The graft was nonfunctional at the time of presentation. Abdominal ultrasound and computed tomography scan demonstrated 1.8 cm well-defined, round enhancing lesion, confined to the renal allograft and suspicious for malignancy. Pathological examination of graft nephrectomy specimen showed gross, histopathological, and immunohistochemical features of eosinophilic chromophobe RCC. Fifty-five months after surgery, the patient was alive and free of malignancy. To the best of our knowledge, only five chromophobe RCCs originating in a renal allograft were previously described in English literature. We suggest that chromophobe RCC should be considered in the differential diagnosis of renal allograft mass, including eosinophilic tumours, and emphasise the importance of periodic screening of renal allograft in all renal transplant recipients.

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Section: Discussionmentioning

confidence: 99%

Incidental Eosinophilic Chromophobe Renal Cell Carcinoma in Renal Allograft

Alharbi

Turki

Aloudah

et al. 2017

Case Reports in Transplantation

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“…4 A review of the current literature identifies 4 cases of multicentric RCC. 5,6 Recurrence of IgA nephropathy after kidney transplant is common, while development of a tumor on the allograft is anecdotal. However, to date, no data exist in the literature regarding the presentation of both pathologies after 25 years of follow-up.…”

Section: Discussionmentioning

confidence: 99%

Untitled

Melandro

Guglielmo²,

Nudo³

et al. 2016

Exp Clin Transplant

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With improvements in immunosuppressive therapy, patient and graft survival in renal transplant recipients have been prolonged. Increasing donor age and patient survival rates have been related to an increase in the number of de novo tumors.Posttransplant malignancy in these patients is an important cause of graft loss and death in these patients. Among cancers occurring after a kidney transplant, renal cell carcinoma is the fifth most common malignancy after lymphoproliferative disorders, and skin, gastrointestinal, and lung cancers. When nonmelanoma skin cancers and in situ carcinoma of the cervix are excluded from malignancies, renal cell carcinoma accounts for 2% of all cancers in the general population, which increases to 5% in solid-organ recipients. The majority of renal cell carcinomas found in transplant recipients develop in the recipient's native kidneys, but only 9% of tumors develop in the allograft itself. Tumors transmitted by donors represent only 0.02% to 0.2% of cases. Most de novo allograft renal cell carcinomas are single tumors. The mechanisms of development of renal cell carcinoma in renal grafts are not completely understood.

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“…The mean time lapse between kidney transplantation and de novo RCC in the allograft varies between 3 and 17 years [5,9,10] (current case: 13 years). CT scan and arteriography, conventional ultrasonography, percutaneous targeted renal biopsy and magnetic resonance imaging (MRI) are the most commonly described diagnostic tools in the literature [5,11,12].…”

Section: Discussionmentioning

confidence: 99%

De novo Renal Cell Carcinoma in a Kidney Allograft with Focus on Contrast-Enhanced Ultrasound

Pichler¹,

Heidegger²,

Bösmüller³

et al. 2014

Urol Int

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The development of de novo renal cell carcinoma (RCC) in a transplanted kidney is a rare condition. Currently, this is the second case report of a 41-year-old man in whom carcinoma of a renal allograft was detected by contrast-enhanced ultrasound (CEUS). An abdominal CT scan was not conclusive enough to differentiate between septal enhancement of a cyst and a low vascularized tumor. CEUS confirmed a solid, homogeneously enhancing but hypoechoic and hypovascular lesion compared to the surrounding kidney parenchyma without septal enhancement. Therefore, the patient underwent nephron-sparing surgery (NSS), affirming papillary RCC type 2. Graft function remained unchanged postoperatively; 12 months after NSS, no local recurrence or distant metastasis was described. CEUS seems to be a minimally invasive and efficient imaging option if other diagnostic tools cannot clearly exclude RCC, with the advantage of wide-ranging use, especially in cases of impaired renal function.

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De novo Renal Cell Carcinoma in a Kidney Allograft 13 Years after Transplantation: A Case Report and Review of the Literature

Cited by 16 publications

References 18 publications

Incidental Eosinophilic Chromophobe Renal Cell Carcinoma in Renal Allograft

Incidental Eosinophilic Chromophobe Renal Cell Carcinoma in Renal Allograft

Untitled

De novo Renal Cell Carcinoma in a Kidney Allograft with Focus on Contrast-Enhanced Ultrasound

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