De novo design and synthesis of a novel colorimetric fluorescent probe based on naphthalenone scaffold for selective detection of hypochlorite and its application in living cells

Research progress in pharmacological activities and structure-activity relationships of tetralone scaffolds as pharmacophore and fluorescent skeleton

“…A fluorescent probe named ADT-MAM (Fig. 14, 19), was reported by Wu group for the first time to monitor the level of ClOin the biological microenvironment [124]. The probe was designed and synthesized from tetralone backbone, in which the acylhydrazone schiff base was introduced as a linker to connect the fluorescent group (DTC) and the recognition group diaminomaleonitrile.…”

A novel colorimetric and fluorescence turn-on pH sensor with a notably large Stokes shift for its application

“…Synthesis of compound 2-((7-(dimethylamino) -4,5dihydronaphtho [1,2-b] thiophen -2-yl) methylene) malononitrile (DDTM) A solution of DTC [33] (0.0500 g, 0.19 mmol, 1.0 equiv.) and malononitrile (0.0130 g, 0.19 mmol, 1.0 equiv.)…”

A Near-Infrared Fluorescent Probe for Recognition of Hypochlorite Anions Based on Dicyanoisophorone Skeleton

“…In addition, the fluorescence probing method was paid more attention as an excellent detection tool, which has realized the detection of many active species [ 19 , 20 , 21 , 22 , 23 ]. Fluorescence probes for the detection of hypochlorite anions have been reported continuously in recent years [ 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ]. Among them, some chemodosimeters using a diaminomaleonitrile group as the reaction site were used to detect hypochlorite anions, which had many advantages, such as specific recognition, high selectivity, and fast response.…”

“…Among them, some chemodosimeters using a diaminomaleonitrile group as the reaction site were used to detect hypochlorite anions, which had many advantages, such as specific recognition, high selectivity, and fast response. However, most chemodosimeters for the hypochlorite anion could hardly achieve near-infrared fluorescence emission and did not have a large Stokes shift ( Table S1 ) [ 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ]. It is well known that NIR fluorescent probes with a large Stokes shift have more advantages due to good applications in biological systems [ 47 ].…”