DDT Storage in the US Population

Quinby, Griffith E.; Hayes, Wayland J.; Armstrong, J. F.; Durham, William F.

doi:10.1001/jama.1965.03080030019004

Cited by 59 publications

(14 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…for females. On the other hand, HAYES et al (1965) found that females stored significantly higher levels of p,p'-DDT and of beta-BHC than did males. Application of a recently developed procedure has indicated that concentrations of several organochlorine pesticides occur at higher levels in blood from males than from females in the general population (DALE et al 1966 a, 1966 b, andunpublished data).…”

Section: C) Sexmentioning

confidence: 83%

“…The groups studied were people from Europe, America, and South Afriea, people originating in countries surrounding the Mediterranean Sea, native Israelis, Yemen Jews, and Indian Jews. In another study, a comparison between 13 persons of the Negroid race with 12 Caucasians indicated that there was no significant difference in the storage of any of the organochlorine pesticides in the fat of people in New Orleans based on race (HAYES et al 1965).…”

Section: Ih Interaction With Physiologie States A) Speciesmentioning

confidence: 96%

“…The correlation coeflicients for tissue storage of various pesticides with respect to age were: p,p 0.268;0.207;total BHC isomers,0.348;and dieldrin,0.323. 3 Somewhat smaller correlation coeflicients (DDT, 0.134; total 0.126) were derived from the data of QUINBY et al (1965). The data of DALE and QUINBY (1963) yielded negative correlation coeflicients for p,p , total DDT-derived material (-0.089), and BHC (-0.506) and a low positive value for dieldrin (0.120).…”

Section: B) Agementioning

confidence: 98%

“…Studies of complete meals indicated that the average DDT intake for the general population in the United States has varied between 0.164 mg.jperson/day in -54 (WALKER et al 1954) and 0.038 mg.jperson/day in 1962-64 (DURHAM et al 1965). QUINBY et al (1965) and HOFFMAN et al (1964) have noted that DDT storage in body fat in the general population has remained essentially stable since 1950. When first measured in 1950, the DDT storage level was 5.3 p.p.m.…”

Section: E) Hereditary and Induced Changes In Enzyme Systemsmentioning

confidence: 99%

See 3 more Smart Citations

Residue Reviews / Rückstands-Berichte

1967

View full text Add to dashboard Cite

Section: C) Sexmentioning

confidence: 83%

Section: Ih Interaction With Physiologie States A) Speciesmentioning

confidence: 96%

Section: B) Agementioning

confidence: 98%

Section: E) Hereditary and Induced Changes In Enzyme Systemsmentioning

confidence: 99%

See 2 more Smart Citations

Residue Reviews / Rückstands-Berichte

1967

View full text Add to dashboard Cite

“…1971). Present evidence indicates that Western man consumes, as contaminants, about 10 Jlg of DDT or its metabolites a day (Quinby et al 1965). Hayes (1965) observed that in mammals high levels of DDT are stored in the testis and ovary, but that less is stored in the male.…”

Section: Introductionmentioning

confidence: 89%

Mutagenicity of DDT in Mice, Drosophila melanogaster and Neurospora crassa

Clark¹

1974

Aust. Jnl. Of Bio. Sci.

View full text Add to dashboard Cite

The pesticide DDT was examined for possible mutagenicity in mice, D. melanogaster and N. crassa. Through the use of the dominant-lethal assay it was found that acute oral doses of DDT (2 x 150 mg/kg body weight) in male mice induced dominant lethal mutations in early spermatid and spermatocyte stages. Chronic oral doses of DDT (2 x 100 mg/kg body weight per week for 10 weeks) in male mice caused a persistent increase in the number of dominant lethal mutations. Histological sections showed that chronic treatment of mice with DDT caused changes in seminiferous tubule morphology and degeneration of B-type spermatogonia. Acute treatment of mice with DDT caused an increase in spermatocyte chromosome breakage, stickiness and precocious separation of the X and Y bivalent.Oral treatment of male Canton-S D. melanogaster with DDT caused an increase in dominant lethality in early spermatid and spermatocyte stages. DDT also caused non-disjunction of the X and Y chromosomes at the spermatocyte stage in treated male y/R(1)2,vj/B s yy+ D. melanogaster. The shift in sex ratio is discussed in terms of breakage of the ring-X chromosome. Treatment of a population of Canton-S D. melanogaster with DDT for eight months did not cause any increase in frequency of second-chromosome recessive lethal mutations.In tests for the induction of recessive lethal mutations in the ad-3 region of an N. crassa heterokaryon the results were inconclusive. However, in the host-mediated assay with N. crassa and mice as the host, DDT did not appear to be mutagenic.The results show that DDT has a deleterious effect on reproduction in mice and is a weak mutagen in both mice and D. melanogaster.

show abstract

Chlorinated Hydrocarbon Insecticides in Human Body Fat in the United States

Zavon¹

1965

JAMA

View full text Add to dashboard Cite

DDT Storage in the US Population

Cited by 59 publications

References 10 publications

Residue Reviews / Rückstands-Berichte

Residue Reviews / Rückstands-Berichte

Mutagenicity of DDT in Mice, Drosophila melanogaster and Neurospora crassa

Chlorinated Hydrocarbon Insecticides in Human Body Fat in the United States

Contact Info

Product

Resources

About