DDT exposure in early childhood and female breast cancer: Evidence from an ecological study in Taiwan

Chang, Simon; El‐Zaemey, Sonia; Heyworth, Jane; Tang, Meng Chi

doi:10.1016/j.envint.2018.10.023

Cited by 18 publications

(9 citation statements)

References 27 publications

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“…Although we did not observe an increased risk of BC associated with PAH-albumin adducts, other environmental exposures such as DDT and perfluoroalkly substances have been reported to be associated with BC in Taiwan 27 , 28 . In our systematic review of epidemiological literature on environmental exposure and BC risk, we concluded that studies enriched for women at higher BC risk through family history, younger age of onset and/or genetic susceptibility consistently support an association between an environment exposure and BC risk 29 .…”

Section: Discussioncontrasting

confidence: 92%

Reproductive and environmental exposures and the breast cancer risk in Taiwanese women

Yang

Lin

et al. 2021

Sci Rep

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Breast cancer (BC) incidence is increasing around the globe, including in Taiwan, though the cause of the increasing incidence is less clear. We followed up 11,296 Taiwanese females who did not have BC at baseline, and ascertained new invasive BC (N = 351) through data linkage to the National Cancer Registry from 1991 to 2018 to examine whether reproductive, lifestyle and environmental risk factors including polycyclic aromatic hydrocarbons (PAH) were associated with BC risk. We conducted a nested case–control study using baseline blood available from a total of 305 women with BC and 598 women without BC matched on time in cohort. We examined the association of PAH-albumin adducts and BC risk using conditional logistic regression models. Age at menarche (HR 0.6 (95% CI 0.5–0.9) for ≥ 15 vs. < 13 years) and multiparity were associated with BC risk (HR 2.0 (95% CI 1.4–2.8), 2.8 (1.9–4.2), and 2.4 (1.0–5.0) for 3–4, 1–2 and 0 live birth, compared with women ≥ 5 births). PAH-albumin adducts were not associated with BC risk. Given the increasing BC incidence in Taiwan, there is a need to identify environmental factors that are important to this population.

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Section: Discussioncontrasting

confidence: 92%

Reproductive and environmental exposures and the breast cancer risk in Taiwanese women

Yang

Lin

et al. 2021

Sci Rep

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Section: Discussionmentioning

confidence: 99%

“…For example, in the 1950s, the Taiwanese government implemented a program to eradicate malaria that included the large-scale use of DDT residual spray. A study by Chang et al later showed that women who were born between 1951 and 1959 and exposed to DDT during childhood had a subsequent increased incidence of breast cancer [17]. is increase may be attributable to various factors, including hormonal and reproductive risk factors such as early menarche, late menopause [18], low parity, older age at first live birth [19], low prevalence of breastfeeding [20], high-fat intake, alcohol consumption, and low levels of physical activity.…”

Section: Yearsmentioning

confidence: 99%

Cancer Incidence Characteristic Evolution Based on the National Cancer Registry in Taiwan

Huang

Chen

2020

Journal of Oncology

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Introduction. Taiwan has committed itself to cancer prevention. This study investigates the impact of cancer prevention on cancer incidence in Taiwan. Objective. This study describes the secular trends and present status of cancer incidence in Taiwan during the years of 1988 to 2016. Methods. Age-standardized incidence rates (ASRs), age-specific incidence, and sex ratios for all cancers were calculated using data from the Taiwan Cancer Registry System for the years 1988 to 2016. Results and Conclusions. ASRs of cancer for males increased from 150.93 per 105 individuals in 1988 to 330.03 per 105 individuals in 2016, and, for females, they increased from 124.18 per 105 individuals in 1988 to 269.5 per 105 individuals in 2016. We found that cancer incidence has begun at younger ages and that the rates of cancer incidence are increasing faster. This study shows that the incidence of cancer in males has decreased slightly in recent years, while the incidence of cancer in females has continued to increase. The continuous promotion of health literacy, lifestyle modification, HBV and HPV vaccination, and cancer early screening can improve the effectiveness of cancer prevention.

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“…However, BRCA and TP53 mutations are present in only 20% of young breast cancer patients, especially in those with the familial type. Westernization might play an important role in Asia of young breast cancer patients, including environmental (e.g., endocrine-disrupting chemicals, EDCs), dietary (e.g., high fat and alcohol intake), and reproductive factors (e.g., delayed childbearing) 7 , 8 . However, the role of the gut microbiota in premenopausal breast cancer has often been neglected.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive profiles and diagnostic value of menopausal-specific gut microbiota in premenopausal breast cancer

Hou

Ou‐Yang

et al. 2021

Exp Mol Med

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In Western countries, breast cancer tends to occur in older postmenopausal women. However, in Asian countries, the proportion of younger premenopausal breast cancer patients is increasing. Increasing evidence suggests that the gut microbiota plays a critical role in breast cancer. However, studies on the gut microbiota in the context of breast cancer have mainly focused on postmenopausal breast cancer. Little is known about the gut microbiota in the context of premenopausal breast cancer. This study aimed to comprehensively explore the gut microbial profiles, diagnostic value, and functional pathways in premenopausal breast cancer patients. Here, we analyzed 267 breast cancer patients with different menopausal statuses and age-matched female controls. The α-diversity was significantly reduced in premenopausal breast cancer patients, and the β-diversity differed significantly between breast cancer patients and controls. By performing multiple analyses and classification, 14 microbial markers were identified in the different menopausal statuses of breast cancer. Bacteroides fragilis was specifically found in young women of premenopausal statuses and Klebsiella pneumoniae in older women of postmenopausal statuses. In addition, menopausal-specific microbial markers could exhibit excellent discriminatory ability in distinguishing breast cancer patients from controls. Finally, the functional pathways differed between breast cancer patients and controls. Our findings provide the first evidence that the gut microbiota in premenopausal breast cancer patients differs from that in postmenopausal breast cancer patients and shed light on menopausal-specific microbial markers for diagnosis and investigation, ultimately providing a noninvasive approach for breast cancer detection and a novel strategy for preventing premenopausal breast cancer.

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DDT exposure in early childhood and female breast cancer: Evidence from an ecological study in Taiwan

Cited by 18 publications

References 27 publications

Reproductive and environmental exposures and the breast cancer risk in Taiwanese women

Reproductive and environmental exposures and the breast cancer risk in Taiwanese women

Cancer Incidence Characteristic Evolution Based on the National Cancer Registry in Taiwan

Comprehensive profiles and diagnostic value of menopausal-specific gut microbiota in premenopausal breast cancer

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