Reproductive and environmental exposures and the breast cancer risk in Taiwanese women

Wu, Hui‐Chen; Yang, Hwai I.; Lin, Po-Han; Chen, Chien-Jen; Santella, Regina M.; Terry, Mary Beth

doi:10.1038/s41598-021-95290-2

Cited by 6 publications

(3 citation statements)

References 31 publications

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“…In 2017, Shen et al found that plasma PHA was positively associated with breast cancer risk (39). However, Wu et al found no significant association between PHA and breast cancer in 2021 (40).…”

Section: Studies Not Eligible For Meta-analysismentioning

confidence: 99%

Endocrine-disrupting chemicals and breast cancer: a meta-analysis

Liu,

Sun,

Ran

et al. 2023

Front. Oncol.

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BackgroundGlobally, the burden of breast cancer has increased significantly in recent decades. Emerging evidence suggested that endocrine-disrupting chemicals (EDCs), which have the potential to interfere with the function of normal hormones, may play a crucial role in this trend. However, the potential relationships were inconsistent in various studies.Objective and search methodsIn our study, we sought to fully evaluate the currently available epidemiological evidence to ascertain whether certain EDC congeners and their metabolites are related to breast cancer risk. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we conducted a comprehensive literature search of original peer-reviewed publications in three electronic databases: PubMed, Web of Science, and Embase. Publications that covered xenobiotic EDC exposures and breast cancer–confirmed histological results or antecedent medical records or reporting to health registers were taken into consideration.OutcomesThe final result of the literature search was 6,498 references, out which we found 67 publications that matched the requirements for meta-analysis and eight publications for qualitative trend synthesis. In this meta-analysis, statistically significant associations revealed that (i) 1-chloro-4-[2,2,2-trichloro-1-(4-chlorophenyl)ethyl]benzene (p,p'-DDT) and its major metabolite 2,2-bis(4-chlorophenyl)-1,1-dichloroethylene (p,p'-DDE) were somewhat related to a greater risk of breast cancer. However, this relationship only existed in blood serum but not in adipose tissue. (ii) Breast cancer risk was increased by exposure to chlordane and hexachlorocyclohexane. (iii) Five polychlorinated biphenyls (PCB 99, PCB 105, PCB 118, PCB 138, and PCB 183) can increase the risk of breast cancer. (iv) One phthalate congener (BBP) and one per- and polyfluoroalkyl substance congener (PFDoDA) were negatively associated with breast cancer risk. Unfortunately, heterogeneity was not well explained in our review, and a limited number of available prospective studies investigating the associations between EDC exposure and breast cancer were included in our meta-analysis. To elucidate the overall associations, future large, longitudinal epidemiological investigations are needed.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD 42023420927.

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Section: Studies Not Eligible For Meta-analysismentioning

confidence: 99%

Endocrine-disrupting chemicals and breast cancer: a meta-analysis

Liu,

Sun,

Ran

et al. 2023

Front. Oncol.

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“…Pain caused by widowhood or divorce and a range of unhealthy lifestyles are associated with the development of breast cancer (10,17). Also, lack of pregnancy and breastfeeding experience in unmarried women may be associated with breast cancer (18)(19)(20). Previous studies have shown that unmarried breast cancer patients are usually diagnosed at a late stage and have more depressive symptoms.…”

Section: Introductionmentioning

confidence: 99%

Association of marital status and all-cause mortality of metastatic breast cancer patients: A population-based study

Zhu

Lei

2023

Preprint

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Background: Being married is positively associated with survival in patients with various types of malignancy. However, the significance of marital status on the prognosis of metastatic breast cancer (MBC) has not been explored. Methods: Data of MBC patients were extracted from the surveillance, epidemiology, and end results database from 2010 to 2015. Patients were separated into married and unmarried cohorts based on their marital status. The Kaplan–Meier analysis with log-rank test was performed to assess the difference in breast cancer-specific survival (BCSS) and overall survival (OS) between married and unmarried patients. Univariate and multivariate Cox proportional models were performed to assess whether marital status was independently associated OS. Fine-Gray subdistribution hazard method was performed to assess whether marital status was independently associated with BCSS. As potential confoundings, age, race, tumor pathologicalgrade, tumor subtype, chemotherapy, surgery, and metastasis pattern were adjusted in the multivariate model. Results: There were 16513 MBC patients identified, including 8949 married (54.19%) and 7564 unmarried patients (45.81%). When compared to the unmarried patients, married patients were younger (58.85±12.94 vs.63.41±14.75; p < 0.001), received more aggressive treatment, like chemotherapy (p < 0.001), and surgery (p< 0.001). Furthermore, the married population had higher 5‑year BCSS (42.64% vs. 33.17%, p < 0.0001) and OS (32.22% vs. 21.44%, p< 0.0001) rates. The multivariate analysis revealed that marital status was an independent prognostic factor, being married was associated with a significant reduction in the risk of breast cancer-specific (SHR: 0.845; 95% CI: 0.804–0.888; p < 0.001) and all-cause (HR: 0.810; 95% CI: 0.777–0.844; p < 0.001)mortality. In addition, BCSS as well as OS were superior in married populations than unmarried ones in most subgroups. Conclusion: Marital status was an independent prognostic indicator for survival in MBC patients. Married patients experience significant survival benefits in BCSS and OS.

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“…The pain caused by widowhood or divorce and a series of following unhealthy lifestyles are associated with the onset of breast cancer (3,12). Meanwhile, the lack of experience of pregnancy and lactation in unmarried women may also be related to breast cancer (13)(14)(15)(16). Previous studies indicated that unmarried patients with breast cancer were usually diagnosed at an advanced stage and had more depressive symptoms.…”

Section: Introductionmentioning

confidence: 99%

Impact of Marital Status on Prognosis of Patients With Invasive Breast Cancer: A Population-Based Study Using SEER Database

Jiao

Zhu

et al. 2022

Front. Oncol.

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ObjectiveThis study aimed to investigate the prognostic roles of marital status in patients with invasive breast cancer. Method: We extracted the data of patients with invasive breast cancer who were diagnosed during 2010–2015 and had complete staging and molecular typing from the Surveillance, Epidemiology, and End Results (SEER)-18 database. Kaplan–Meier curve method and Cox regression analysis were performed to investigate the differences in breast cancer–specific survival (BCSS) and overall survival (OS) in the total population and various subgroups with different marital statuses.ResultsAmong the 324,062 patients with breast cancer in this study, 55.0%, 40.0%, and 5.0% were married, unmarried, and unknown, respectively; 51.8%, 32.2%, 10.5%, and 5.5% were patients with Stages I, II, III, and IV breast cancer, respectively. The 5-year BCSS and OS of married patients were 92.6% and 88.1%, respectively, higher than those of unmarried patients (88.3% and 78.1%, P < 0.001). After adjustment for sex, age, T and N stages, histological grade, insurance status, race, year of diagnosis, and molecular subtypes, married status was an independent predictor of better BCSS [hazard ratio (HR) = 0.775, 95% confidence interval (CI) = 0.753–0.797, P < 0.001) and OS (HR = 0.667, 95% CI = 0.653–0.681, P < 0.001). After multivariate analysis of various subgroups of sex, age, stage, histological grade, insurance status, race, and molecular subtype, married status was an independent predictor of better BCSS in all subgroups except for Grade IV, age < 35 years, and uninsured subgroups. Marital status was an independent predictor of better OS in all subgroups except the subgroup with age <35 years.ConclusionsIn conclusion, marital status was an independent prognostic factor for breast cancer. The unmarried patients with breast cancer had a worse prognosis, except for the subgroup with age <35 years. Hence, unmarried patients with breast cancer and age ≥35 years may need additional psychosocial and emotional support to achieve more prolonged survival, besides active treatment of primary disease.

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Reproductive and environmental exposures and the breast cancer risk in Taiwanese women

Cited by 6 publications

References 31 publications

Endocrine-disrupting chemicals and breast cancer: a meta-analysis

Endocrine-disrupting chemicals and breast cancer: a meta-analysis

Association of marital status and all-cause mortality of metastatic breast cancer patients: A population-based study

Impact of Marital Status on Prognosis of Patients With Invasive Breast Cancer: A Population-Based Study Using SEER Database

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