DC Respond to Cognate T Cell Interaction in the Antigen-Challenged Lymph Node

Curato, Caterina; Bernshtein, Biana; Zupančič, Eva; Dufner, Almut; Jaitin, Diego Adhemar; Giladi, Amir; David, Eyal; Chappell‐Maor, Louise; Leshkowitz, Dena; Knobeloch, Klaus–Peter; Amit, Ido; Florindo, Helena F.

doi:10.3389/fimmu.2019.00863

Cited by 17 publications

(15 citation statements)

References 62 publications

(69 reference statements)

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“…Finally, our data show that upon cognate interaction psDC acquire an antiviral program and they are more protected. Those data are supported by a study where it is shown that this also happens in DC in vivo 270 . Even if after immune synapse many DC die, some of these postsynaptic Dendritic Cells activate a program that improves their performance 271 .…”

Section: Discussionsupporting

confidence: 68%

Mitochondrial DNA transfer through Exomes during Immune Synapsis primes Antiviral Innate Immune Response in Dendritic Cells

Grajales¹

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TNTs Tunneling nanotubes Tsg101 tumor susceptibility gene WB Western Blot Receptor molecules (red) are internalized at the central area of the T cell-APC contact; they can be degraded or recycled through the endolysosomal pathway. (4) Multivesicular bodies (MVB) are formed from the endosomes, through specific sorting of their components. MVB can deliver their content into the immune synapse cleft, as extracellular vesicles (i.e.: exosomes) or soluble components. Viruses can use this pathway to spread into APCs. (5)Ectosomes can be formed, excised and released from the plasma membrane to the IS cleft.

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Section: Discussionsupporting

confidence: 68%

Mitochondrial DNA transfer through Exomes during Immune Synapsis primes Antiviral Innate Immune Response in Dendritic Cells

Grajales¹

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“…Barry et al found that intratumorally stimulatory DCs play important roles in the stimulation of cytotoxic T cells and driving the immune responses against cancer (28). Additionally, DCs were found to play a central role in the regulation of the balance between CD8 T-cell immunity vs. tolerance to tumor antigens (29)(30)(31). Of the antigen-presenting cells, DCs are the most effective in the activation of naïve T cells and induce an immune memory response in cancer (32).…”

Section: Discussionmentioning

confidence: 99%

The Immune-Related Gene HCST as a Novel Biomarker for the Diagnosis and Prognosis of Clear Cell Renal Cell Carcinoma

et al. 2021

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Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney tumor worldwide. Analysis of The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases showed that the immune-related gene (IRG) hematopoietic cell signal transducer (HCST) could provide guidance for the diagnosis, prognosis, and treatment of ccRCC. The RNA-seq data of ccRCC tissues were extracted from two databases: TCGA (https://www.cancer.gov/about-nci/organization/ccg/research/structural-genomics/tcga) and GEO (https://www.ncbi.nlm.nih.gov/geo/). Corresponding clinical information was downloaded from TCGA. Immune-related gene data were extracted from the IMMPORT website (https://www.immport.org/). Differential analysis with R software (https://www.r-project.org/) was used to obtain a prognosis model of ccRCC IRGs. The differences were combined with the clinical data to assess the usefulness of the HCST as a prognostic biomarker. Based on data obtained from the Oncomine (https://www.oncomine.org/), Human Protein Atlas (https://www.proteinatlas.org/), and PubMed (https://pubmed.ncbi.nlm.nih.gov/) databases, the expression levels of the HCST in ccRCC, clinical-pathological indicators of relevance, and influence on prognosis were analyzed. Regulation of the HCST gene in ccRCC was assessed by gene set enrichment analysis (GSEA). In TCGA/GEO databases, the high HCST expression in tumor tissues was significantly correlated to the TMN stage, tumor grade, invasion depth, and lymphatic metastasis (p < 0.05). The overall survival (OS) of patients with high HCST gene expression was significantly lower than that of patients with low HCST gene expression (p < 0.001). Multivariate Cox regression analysis suggested that the HCST expression level [hazard ratio (HR) = 1.630, 95% confidence interval (CI) = 1.042–2.552], tumor cell grade (HR = 1.829, 95% CI = 1.115–3.001), and distant metastasis (HR = 2.634, 95%, CI = 1.562–4.442) were independent risk factors affecting the OS of ccRCC patients (all, p < 0.05). The GSEA study showed that there was significant enrichment in cell adhesion, tumorigenesis, and immune and inflammatory responses in HCST high expression samples. Hematopoietic cell signal transducer expression was closely associated with the levels of infiltrating immune cells around ccRCC tissues, especially dendritic cells (DCs). In conclusion, the present study suggested that the HCST was interrelated to the clinicopathology and poor prognosis of ccRCC. High HCST expression was also closely correlated with the levels of tumor-infiltrating immune cells, especially DCs.

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“…In this study, the expression levels of MHC II, CD86, CD80, and CD40 increased through TCDD stimulation. DCs trigger T cells through MHC II, CD86, CD80, and CD40 presentation and costimulation, subsequently directly activating T cells [ 21 ]. CD40 activation induced Fas-dependent apoptosis and NF-kappaB/AP-1 signaling in human intrahepatic biliary epithelial cells [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin on T Cell Differentiation in Primary Biliary Cholangitis

She

Wang

et al. 2020

BioMed Research International

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Exposure to dioxins, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), is reported to affect the autoimmune system and increase the risk of autoimmune disease. Generally, dioxin exerts its toxicity via aryl hydrocarbon receptor (AhR). Primary biliary cholangitis (PBC) is a chronic autoimmune disease, and its pathogenesis involves the interplay between immune and environmental factors. This study showed the effect of dendritic cells (DCs) activated by TCDD on naïve CD4+ T cell differentiation in patients with PBC. CD14+ mononuclear cells were isolated from peripheral blood mononuclear cells (PBMCs) of patients with PBC and healthy people by magnetic cell separation and introduced into DCs. Two days after stimulation by TCDD, DCs were cocultured with naïve CD4+ T cells in a ratio of 1 : 2 for 3 days. Then, differentiation-related factors for naïve CD4+ T cells were detected by real-time fluorescence quantitative polymerase chain reaction, enzyme-linked immunosorbent assay, and flow cytometry. The results showed that TCDD-activated DCs could promote Th1 and Th17 differentiation in patients with PBC. Therefore, this study demonstrated TCDD as an AhR agonist in regulating naïve CD4+ T cell differentiation in patients with PBC.

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DC Respond to Cognate T Cell Interaction in the Antigen-Challenged Lymph Node

Cited by 17 publications

References 62 publications

Mitochondrial DNA transfer through Exomes during Immune Synapsis primes Antiviral Innate Immune Response in Dendritic Cells

Mitochondrial DNA transfer through Exomes during Immune Synapsis primes Antiviral Innate Immune Response in Dendritic Cells

The Immune-Related Gene HCST as a Novel Biomarker for the Diagnosis and Prognosis of Clear Cell Renal Cell Carcinoma

Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin on T Cell Differentiation in Primary Biliary Cholangitis

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