Mitochondrial DNA transfer through Exomes during Immune Synapsis primes Antiviral Innate Immune Response in Dendritic Cells

Abstract

TNTs Tunneling nanotubes Tsg101 tumor susceptibility gene WB Western Blot Receptor molecules (red) are internalized at the central area of the T cell-APC contact; they can be degraded or recycled through the endolysosomal pathway. (4) Multivesicular bodies (MVB) are formed from the endosomes, through specific sorting of their components. MVB can deliver their content into the immune synapse cleft, as extracellular vesicles (i.e.: exosomes) or soluble components. Viruses can use this pathway to spread into APCs. (5)Ectosomes can be formed, excised and released from the plasma membrane to the IS cleft.