Daylight photodynamic therapy vs. Conventional photodynamic therapy as skin cancer preventive treatment in patients with face and scalp cancerization: an intra‐individual comparison study

Abstract

The current findings suggest equal preventive potential of DL-PDT vs. C-PDT against the formation of new NMSCs in patients exhibiting actinic field damage.

Short incubation fractional CO2 laser‐assisted photodynamic therapy vs. conventional photodynamic therapy in field‐cancerized skin: 12‐month follow‐up results of a randomized intraindividual comparison study

“…On the other hand, we should underline that incubation time is not a limitation of daylight PDT. 28 To the best of our knowledge, this is the first study to evaluate the efficacy of AFXL-PDT with a short incubation time as a preventive treatment in the development of new AKs and compare it with that of CPDT with a 3-h incubation time in immunocompetent patients suffering from clinically and histologically proven actinic field damage. CPDT has shown efficacy in the treatment of both clinically evident and subclinical lesions.…”

“…Although this was not studied in our trial, taking into account that daylight PDT has proved efficacy in the same clinical scenario (prevention of new AK in cancerized fields), we expect that this would not change with the combination. On the other hand, we should underline that incubation time is not a limitation of daylight PDT …”

The safety and efficacy of daylight photodynamic therapy in the treatment of actinic keratoses: a systematic review and meta‐analysis

“…In addition, almost all the studies reported fewer side effects with DLPDT than with CPDT. For example, all patients treated with CPDT experienced a strong burning sensation and pain, while DLPDT proved to be almost painless . Moreover, Lacour et al .…”

“…For example, all patients treated with CPDT experienced a strong burning sensation and pain, while DLPDT proved to be almost painless. 34 Moreover, Lacour et al 24 reported that DLPDT has no side effects that could generate discomfort to patients, because about 79% of patients in one particular trial were not inconvenienced by any adverse event during DLPDT treatment. Therefore, we did not conduct pooled analyses of adverse events in this study.…”

Day light photodynamic therapy with BF-200 ALA: A case series

“…In the last years, the use of daylight PDT (DL-PDT) has become more widespread as an alternative to conventional PDT (cPDT) with red light around 635 nm. Recent studies (Sotiriou, 2017a;Apalla, et al, 2017;Sotiriou, 2017b;Evangelou, et al, 2017) with follow ups up to 12 months showed one of the main advantages of DL-PDT when compared with the cPDT: a lower rate of side effects/adverse reactions, especially pain, without implying a loss of efficacy.…”