Day surgery is effective and safe for patients with great saphenous vein varices who meet American Society of Anesthesiologists I-II grading

Xiong, Yulin; Xu, Qiu-Shuang; Wang, Y; Zhu, Maoen; Wang, J; Guo, Qulian

doi:10.4103/1119-3077.181366

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…The study was conducted in the Gastrointestinal Endoscopy Department on January 10, 2021. Inclusion criteria were patients scheduled for gastrointestinal endoscopy who had the American Society of Anesthesiologists (ASA) classification grade I/II [ 8 ] and body mass index (BMI) ≤ 30. Exclusion criteria were patients who had (1) anemia (hemoglobin < 90 g/L), (2) albumin level < 30 g/L, (3) platelet count < 50 × 10 9 /L, (4) anticipated difficult airway, (5) significant respiratory or circulatory dysfunction before gastrointestinal endoscopy, (6) severe neuropsychiatric disorders, (7) allergic reactions or contraindications to benzodiazepines, opioids, propofol, flumazenil, naloxone, or drug ingredients, or (8) previously received remimazolam, propofol, or sufentanil.…”

Section: Methodsmentioning

confidence: 99%

Randomized controlled trial for anesthesia during gastroscopy: interactions between remimazolam and propofol in combination with sufentanil

et al. 2023

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Background Remimazolam is a new short-duration anesthetic currently used for gastroscopy and can be mixed with propofol and potent opioids. Aim The study aimed to investigate the synergistic interaction between remimazolam and propofol after sufentanil administration and to determine the appropriate dose ratios between remimazolam and propofol. Method This study used a randomized controlled design. Patients scheduled for gastrointestinal endoscopy were included and randomized into five groups. The randomized block design was applied at a randomization ratio of 1:1. Patients in each group received sufentanil (0.1 μg/kg) and the calculated doses of remimazolam and propofol. Using the up and down method, the median effective dose (ED50) and the 95% confidence interval (CI) were determined based on whether the eyelash reflex disappeared in each treatment group. Isobolographic analysis was used to analyze the presence of drug interactions. The interaction coefficient and the dose ratio between remimazolam and propofol were calculated by algebraic analysis. Statistical analysis was performed using interval estimates and 95% CI for statistical attributes. Results Cross-sectional analysis of the isobologram showed a clinically significant synergistic effect between remimazolam and propofol. When 0.016, 0.032, and 0.047 mg/kg of remimazolam were combined with 0.477, 0.221, and 0.131 mg/kg of propofol, the interaction coefficients were 1.04, 1.21, and 1.06, respectively. The dose ratio of remimazolam to propofol was approximately 1:7. Conclusion Remimazolam and propofol have synergistic clinical effects. A strong synergistic effect was observed when the remimazolam and propofol dose ratio was 1:7 (mg/kg). Clinical trial The study protocol was registered at the Chinese Clinical Trial Registry (ChiCTR2100052425).

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Section: Methodsmentioning

confidence: 99%

Randomized controlled trial for anesthesia during gastroscopy: interactions between remimazolam and propofol in combination with sufentanil

et al. 2023

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Offene Varizenchirurgie – wann ambulant, wann stationär?

Frings¹,

Rass²,

Bruning³

et al. 2020

Phlebologie

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Zusammenfassung Hintergrund Die offene Varizenchirurgie kann sowohl in einem ambulanten als auch in einem stationären Setting durchgeführt werden. Aktuelle Leitlinien zur Therapie der Varikose nehmen zu der Frage, welche Patienten ambulant und welche stationäre zu operieren sind, nicht Stellung. Fragestellung Erarbeitung von Kriterienkatalogen zur Frage einer ambulanten oder stationären Varizenoperation. Material und Methode PubMed-Recherche zur Fragestellung und basierend auf den Literaturdaten Erarbeitung eines Delphi-Konsensus der Autoren. Ergebnisse Zur Frage, ob eine Varizenchirurgie ambulant oder stationär durchgeführt werden kann, existieren lediglich 2 monozentrische retrospektive Analysen sowie eine Registerstudie. In diesen Studien werden ambulante Operationen im Wesentlichen bei Patienten mit Normalgewicht und ASA-Stadium 1 durchgeführt. Gut geeignete Lokalbefunde für eine ambulante Operation sind Primäreingriffe und ein geringeres C-Stadium der CEAP-Klassifikation. Für eine stationäre Varizenoperation sprechen ausgedehnte Befunde, bei denen mehr als eine Crosse saniert werden muss, Rezidiveingriffe in der Leiste oder der Kniekehle, vorangegangene thromboembolische Ereignisse, eine erhöhte Blutungsneigung aufgrund monströser Varizen oder einer Antikoagulation, Hautkomplikationen wie ein Ulcus cruris oder eine schwere Stauungsdermatitis bzw. Dermatosklerose sowie ein BMI über 30 bei Crossektomie. Schlussfolgerungen Basierend auf Literaturdaten und Expertenmeinungen konnten Kriterienkataloge für eine ambulante versus stationäre offene Varizenchirurgie erarbeitet werden.

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Day surgery is effective and safe for patients with great saphenous vein varices who meet American Society of Anesthesiologists I-II grading

Abstract: DS for GSVV is an effective and safe procedure, which was the same as IS. However compared with IS, DS could decrease the average medical cost for patients and hospital stays obviously. Hence DS for GSVV is a win-win procedure for patient and health care.

Cited by 2 publications

References 15 publications

Randomized controlled trial for anesthesia during gastroscopy: interactions between remimazolam and propofol in combination with sufentanil

Randomized controlled trial for anesthesia during gastroscopy: interactions between remimazolam and propofol in combination with sufentanil

Offene Varizenchirurgie – wann ambulant, wann stationär?

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