Day 3 embryo transfer may have better pregnancy outcomes in younger than 35-year-old patients with poor ovarian response

Abstract

Objective To explore the pregnancy outcomes of embryo transfer with D2 or D3 embryos in patients with poor ovarian response. Methods The pregnancy outcomes of 620 patients who had poor ovarian response and underwent the first in vitro fertilization-embryo transfer (IVF-ET) were retrospectively analyzed. Of the 620 cycles, all available fresh D2 embryos were used in 365 cycles (day 2 embryo transfer) and all available fresh D3 embryos were used in 255 cycles (day 3 embryo transfer) without superfluous embryos for freezing. Results There was a significant difference in clinical pregnancy rate between day 2 (32.73 %) and day 3 (50.83 %) embryo transfer in younger than 35-year-old patients, but no significant differences in implantation rate, live birth rate and spontaneous abortion rate (P>0.05). There were similar pregnancy outcomes between day 2 and 3 embryo transfer in 35-year and older patients. Conclusion D3 embryo transfer may have better pregnancy outcomes in younger than 35-year-old patients with poor ovarian response.

Day 2 versus day 3 embryo transfer in patients with in vitro fertilization and only one zygote with two pronuclei

“…However, Zhu et al showed that the clinical pregnancy rate of D3 embryo transplantation was higher than that of D2 embryo transplantation in patients younger than 35 years of age with a normal or poor ovarian response. 6 Unlike the studies mentioned above, the present study showed that D2 embryo transfer had similar rates of positive hCG, clinical pregnancy, miscarriage, and live birth to D3 embryo transfer in patients with only one 2PN, regardless of the patient's age. This discrepancy between studies may be due to differences in the study design and grouping criteria.…”

The effect of day 2 versus day 3 embryo transfer on early pregnancy outcomes in women with a low yield of fertilized oocytes

“…Interestingly, prior studies have suggested that poor ovarian response may impact clinical pregnancy rates depending on D2 or D3 [9,10]. Xin and colleagues further suggested a possible benefit to D3 transfer amongst younger women with fewer than six oocytes retrieved [10]. Our data in contrast illustrate that neither ovarian response (given the low number of oocytes retrieved in the fertilization rate ≥ 50% subgroup) nor ovarian reserve (determined by AMH) impact clinical outcomes for D2 vs. D3 embryo transfers.…”

“…Additionally, women with a fertilization rate ≥ 50%, corresponding to those with fewer than five oocytes retrieved based on our study inclusion criteria, had similar outcomes regardless of transfer. Interestingly, prior studies have suggested that poor ovarian response may impact clinical pregnancy rates depending on D2 or D3 [9,10]. Xin and colleagues further suggested a possible benefit to D3 transfer amongst younger women with fewer than six oocytes retrieved [10].…”

“…Importantly, further questions have been raised regarding whether the timing of embryo transfer impacts outcomes for specific populations, for example those with poor ovarian response, as the increased ability to select better quality embryos on day 3 may compensate for reduced oocyte quantity and quality in these women. While Bahceci et al found that increased time in culture negatively impacted clinical pregnancy rates in women of all ages with poor ovarian response (five or fewer follicles identified after ovarian stimulation), another study by Xin et al showed that patients under age 35 with poor ovarian response (normal ovarian reserve but fewer than six oocytes retrieved) may benefit from a D3 embryo transfer in terms of clinical pregnancy rates [9,10]. However, ovarian response was defined differently in these studies.…”

Продленное Культивирование Эмбрионов В Естественных И Модифицированных Циклах Программ Вспомогательных Репродуктивных Технологий

“…Введение: Применение гормональной стимуляции суперовуляции в программах вспомогательных репродуктивных технологий (ВРТ), позволяет увеличить количество полученных ооцитов на цикл, и соответственно, доступных эмбрионов и бластоцист для выбора на перенос или криоконсервацию, что в конечном итоге позволяет увеличить эффективность программ при лечении бесплодия. Таким образом, благодаря, внедрению и совершенствованию протоколов гормональной стимуляции суперовуляции, эффективность лечения методами ВРТ увеличилась с 20-30 до 40-50% [1]. Однако, несмотря на очевидное преимущество стимуляции суперовуляции в отношении увеличения числа фолликулов и количества получаемых ооцитов, отмечается негативное влияние гормональных препаратов на качество эндометрия [2].…”