The effect of day 2 versus day 3 embryo transfer on early pregnancy outcomes in women with a low yield of fertilized oocytes

Sacha, Caitlin R.; Dimitriadis, Irene; Christou, G.; Souter, Irene; Bormann, Charles L.

doi:10.1007/s10815-018-1157-x

Cited by 5 publications

(2 citation statements)

References 12 publications

(16 reference statements)

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“…3 Sacha et al suggested that transferring embryos on D2 versus D3 in women with a low number of fertilized oocytes ( two 2PN-stage zygotes) does not affect early pregnancy outcomes. 7 A prospective, randomized trial conducted by Shahine et al did not show a difference in the pregnancy outcome between D2 and D3 embryo transfer in poor responders. 8 However, their definition of poor responders was vague.…”

Section: Introductionmentioning

confidence: 92%

Day 2 versus day 3 embryo transfer in patients with in vitro fertilization and only one zygote with two pronuclei

Ye,

Huang,

Wang

et al. 2024

J Int Med Res

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Objective This study aimed to compare the pregnancy outcomes of Day 2 (D2) fresh embryo transfer and D3 fresh embryo transfer in women with only one zygote with two pronuclei (2PN). Methods Data on 432 in vitro fertilization-embryo transfer cycles with only one 2PN zygote from January 2016 to January 2022 were retrospectively collected. A total of 302 fresh embryo transfers on D2 (n = 193) and D3 (n = 109) were analyzed, and pregnancy outcomes were compared. Results The patients’ characteristics were not different between D2 and D3 embryo transfer. There were no significant differences in the rates of clinical pregnancy, early abortion, or live birth between D2 and D3 embryo transfer. A multivariate logistic regression model controlling for age, the fertilization method, the number of oocytes harvested, and the number of high-quality embryos transferred showed that the live birth rate was similar between D2 and D3 embryo transfer. Conclusion In in vitro fertilization-embryo transfer cycles with only one 2PN zygote, D2 fresh embryo transfer may provide similar pregnancy outcomes to those of D3 embryo transfer. D2 embryo transfer may be an option because of the risk of cycle cancellation due to the absence of viable embryos on D3.

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Section: Introductionmentioning

confidence: 92%

Day 2 versus day 3 embryo transfer in patients with in vitro fertilization and only one zygote with two pronuclei

Ye,

Huang,

Wang

et al. 2024

J Int Med Res

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“…All aspects of the artificial reproductive technology (ART) process have benefited from this effort: ovarian hyper‐stimulation protocols, 2 embryo culture conditions, 3 , 4 embryo transfer procedures, 5 , 6 and embryo freezing techniques 7 , 8 have been improved. The choice of embryo to be transferred is based on either morphological criteria at D2 (day 2 post fertilization), 9 at D3, 10 or at the blastocyst stage, 11 or on preimplantation genetic diagnosis (PGD) techniques. 12 , 13 …”

Section: Introductionmentioning

confidence: 99%

Shallow artificial networks with morphokinetic time‐lapse parameters coupled to ART data allow to predict live birth

Benchaïb

Labrune

d′Estaing

et al. 2022

Reprod Medicine & Biology

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Purpose The purpose of this work was to construct shallow neural networks (SNN) using time‐lapse technology (TLT) from morphokinetic parameters coupled to assisted reproductive technology (ART) parameters in order to assist the choice of embryo(s) to be transferred with the highest probability of achieving a live birth (LB). Methods A retrospective observational single‐center study was performed, 654 cycles were included. Three SNN: multilayers perceptron (MLP), simple recurrent neuronal network (simple RNN) and long short term memory RNN (LSTM‐RNN) were trained with K‐fold cross‐validation to avoid sampling bias. The predictive power of SNNs was measured using performance scores as AUC (area under curve), accuracy, precision, Recall and F1 score . Results In the training data group, MLP and simple RNN provide the best performance scores; however, all AUCs were above 0.8. In the validating data group, all networks were equivalent with no performance scores difference and all AUC values were above 0.8. Conclusion Coupling morphokinetic parameters with ART parameters allows to SNNs to predict the probability of LB, and all SNNs seems to be efficient according to the performance scores. An automatic time recognition system coupled to one of these SNNs could allow a complete automation to choose the blastocyst(s) to be transferred.

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Noninvasive embryo evaluation and selection by time-lapse monitoring vs. conventional morphologic assessment in women undergoing in vitro fertilization/intracytoplasmic sperm injection: a single-center randomized controlled study

Meng

Zheng

et al. 2022

Fertility and Sterility

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The effect of day 2 versus day 3 embryo transfer on early pregnancy outcomes in women with a low yield of fertilized oocytes

Cited by 5 publications

References 12 publications

Day 2 versus day 3 embryo transfer in patients with in vitro fertilization and only one zygote with two pronuclei

Day 2 versus day 3 embryo transfer in patients with in vitro fertilization and only one zygote with two pronuclei

Shallow artificial networks with morphokinetic time‐lapse parameters coupled to ART data allow to predict live birth

Noninvasive embryo evaluation and selection by time-lapse monitoring vs. conventional morphologic assessment in women undergoing in vitro fertilization/intracytoplasmic sperm injection: a single-center randomized controlled study

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