Day-2 serum progesterone level and IVF/ICSI outcome: a comparative study

Mahapatro, Akshaya Kumar; Radhakrishan, Abhishek

doi:10.18203/2320-1770.ijrcog20171939

Cited by 3 publications

(4 citation statements)

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“…The day-2 serum progesterone has been estimated as a key hormone in predicting the ART outcome. Studies suggest that a high value of day-2 serum progesterone level was associated with a lower clinical pregnancy rate (Mahapatro and Radhakrishan, 2017). Likewise, other authors found the same result in IVF cycles using the GnRH antagonist protocol (Kolibianakis et al, 2004).…”

Section: Discussionmentioning

confidence: 75%

Assisted reproductive technology outcomes and gene expression in unexplained infertility patients

Vaigauskaitė-Mažeikienė,

Baušytė,

Valatkaitė

et al. 2023

Front. Cell Dev. Biol.

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Background: Unexplained infertility (UI) can be a frustrating and challenging diagnosis for doctors and couples as it can be difficult to understand why they are unable to conceive despite increasing diagnostic tools. Assisted reproductive technology (ART) procedures have been successfully applied to many couples aiming to overcome UI. However, they can be not only expensive but also require multiple cycles to achieve a successful pregnancy. The endometrium and the follicular fluid have been investigated as target tissues not only to determine the cause of UI but also to increase conception rates.Results: In this study, we analyzed the outcomes of ART in 223 UI couples and gene expression associated with DNA modification, cell death, immune response and senescence (TET1, TET2, BCL2, BAK1, HMGA2, IL-6, IL-8) in infertile women’s endometrium and follicular fluid. We found significant differences in women who successfully got pregnant compared to women unable to conceive depending on age, duration of infertility, number of retrieved oocytes, zygotes, transferred embryos. Further, the expression of genes BAK1 (pro-apoptotic), TET2 (associated with epigenetic DNA modification) and IL-6 (associated with immune responses) were significantly higher in the endometrium of women who successfully got pregnant.Conclusion: Younger parental age couples showed higher ART success rates, shorter duration of infertility, higher number of retrieved oocytes, zygotes and transferred embryos. The gene expression analysis revealed significant changes in the endometrium depending on genes associated with cell death and immune response which were upregulated in females with diagnosed unexplained infertility.

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Section: Discussionmentioning

confidence: 75%

Assisted reproductive technology outcomes and gene expression in unexplained infertility patients

Vaigauskaitė-Mažeikienė,

Baušytė,

Valatkaitė

et al. 2023

Front. Cell Dev. Biol.

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“…Fresh ovarian stimulation cycle with ET i. At basal follicular phase Three studies 3,12,13 reported progesterone monitoring in this category. Serum progesterone was measured on day 2 of the menstrual cycle.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Two thresholds were identi ed, P>0.65ng/ml and P>1.5ng/ml. Two studies reported using D3 embryos 3,12 and one study reported both D3 and D5 embryos 13 (Table 1).…”

Section: Study Characteristicsmentioning

confidence: 99%

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Progesterone level in assisted reproductive technology - a Systematic Review and Meta- analysis

Lim,

Hamdan,

Maheshwari

et al. 2024

Preprint

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Currently, many measure progesterone in ART cycles as part of cycle monitoring. Elevated or inadequate progesterone levels during ART cycle monitoring may lead to cycle cancellations or further progesterone supplementation, but practice varies. It remains controversial if measuring progesterone improves clinical outcomes. This review aims to investigate if progesterone levels at different phases of fresh and frozen ART cycles influence pregnancy outcomes, in particular, that pertaining day 3 versus day 5 embryo transfers. A systematic search of EMBASE, MEDLINE, CINAHL and PubMed identified studies between 2000 and 2022. We included studies with women undergoing fresh and frozen IVF/ICSI cycles; with extractable per woman data on pregnancy outcomes where serum progesterone measurement was performed. We excluded studies with intervention or donor cycles. The primary outcome was LBR and the secondary outcomes were OPR, CPR and MR. Eligible studies were included after the initial screen of the titles and abstracts. PICOS study protocol was used. Analysis was done using RevMan5. The study was registered with PROSPERO (registration ID CRD42022382423). 64 studies (N = 57,988 women) were included. In fresh cycles, there is no evidence that elevated progesterone (EP) impacts live birth rate (LBR) at baseline (OR 0.76, 95% CI 0.39–1.49). EP at ovulation trigger is associated with a lower LBR for D3 (P > 1.0ng/ml, OR 0.46, 95% CI 0.38–0.55; P > 1.5ng/ml, OR 0.68, 95% CI 0.47–0.98) but not D5 embryo transfer (P > 1.5ng/ml, OR 0.96, 95% CI 0.81–1.14). In FET cycles, we were unable to meaningfully meta-analyse studies due to significant study heterogeneity. In controlled ovarian stimulation, EP at baseline did not impact on LBR; EP at ovulation trigger is associated with a lower LBR for D3 but not for D5 embryo transfer. In FET cycles, as the studies were heterogeneous, we were unable to combine the data in a meaningful way.

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In Celebration of Women in Molecular and Cellular Reproduction

2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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Day-2 serum progesterone level and IVF/ICSI outcome: a comparative study

Cited by 3 publications

References 9 publications

Assisted reproductive technology outcomes and gene expression in unexplained infertility patients

Assisted reproductive technology outcomes and gene expression in unexplained infertility patients

Progesterone level in assisted reproductive technology - a Systematic Review and Meta- analysis

In Celebration of Women in Molecular and Cellular Reproduction

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