Daun Binahong (Andredera cordifolia Steenis) Sebagai Alternatif Insektisida Terhadap Miasis yang Disebabkan Lalat Chrysomya bezziana (ANREDERA CORDIFOLIA STEENIS (BINAHONG) LEAF AS AN ALTERNATIVE INSECTICIDE AGAINST CHRYSOMYA BEZZIANA CAUSED MYIASIS)

Activity of Sea Cucumber and Spirulina in Wound Healing and Blood Glucose Decreasing in Streptozotocin- Induced Diabetic Rats

“…In general, in this study, in the treatment group that was treated with golden sea cucumbers and gama sea cucumbers, histopathological wound skin on the 21st day still found neutrophil cells and had neovascularization, the average percentage of reepithelialization and collagen area was less than that of diabetic wound controls. These results are different from the results of a study [11] which reported histopathic observations of the wound skin of diabetic rats treated with turmeric rhizome extract ointment on day 21 which had returned to normal, found no neutrophil cells and had neovascularization, the average percentage of reepithelialization and collagen area. more than control diabetic wounds.…”

“…The number of neutrophil cells also correlated with the rate of wound healing, the normal wound control group, the diabetic wound group and the commercial drug group whose wounds had closed completely almost did not find any neutrophil cells, on the other hand the groups that were smeared with golden sea cucumber and gama sea cucumber had wounds that had not completely closed even widened, as in the gold sea cucumber basking group and the gama sea cucumber basking group. Research by [11] healed wounds in diabetic rats treated with turmeric rhizome extract ointment, histopath of the 21st day wound skin was not found in the presence of neutrophils.…”

“…The application of gamma sea cucumber topical accelerated the formation of new blood vessels compared to the golden sea cucumber topical preparation, even the amount was higher than commercial drugs and normal controls, although it was still less than the diabetic wound control group. Neovascularization is needed in the wound healing process to bring oxygen and nutrients that are very necessary for cell metabolism and tissue regeneration [11]. In the group that was rubbed on golden sea cucumbers and gamma sea cucumbers, the percentage of reepithelialization had not reached 100%, as well as the percentage of wound healing.…”

“…In the group that was rubbed on golden sea cucumbers and gamma sea cucumbers, the percentage of reepithelialization had not reached 100%, as well as the percentage of wound healing. According to [11], the faster the re-epithelialization process occurs, the faster the skin reaches normal conditions. In general, the percentage of wound healing in all groups decreased until the 3 rd , 7 th or 14 th day, then until the end of the study, except for the gold sea cucumber bashing group and the gama sea cucumbers bashing group, the percentage value of wound healing was stagnant, that is, all values were not different.…”

Epidemiology of traumatic myiasis due to Chrysomya bezziana in Indonesia

“…However, this disease is not considered to be of strategic national importance and therefore livestock owners rather than veterinarians apply treatments that are highly diverse in manner and outcome. In particular, because effective insecticides, such as Dichlorfenthion (Gusanex®) favoured by veterinarians, are expensive and difficult to find in the markets, less affluent rural farmers depend instead on herbal medicines to kill the larvae in the wound, such as liquid of tobacco extract and others (Sukarsih et al 1989;Wardhana & Diana 2014;Mustika et al 2016;Wientarsih et al 2017). They also traditionally used kerosene, battery carbon with motor oil, gasoline and petrol to treat myiasis (Sukarsih et al 1989).…”