Daucus carota root enzyme catalyzed Henry reaction: A green approach

Synthesis of 2-Aminothiophene Derivatives Catalyzed by Amano Lipase M from Mucor javanicus

“…生物催化, 即以酶 [13] 或生物有机体 [14] 为催 化剂进行的化学转化过程, 酶作为绿色、高效、专一和 可生物降解的催化剂, 已广泛用于药物、农用化学品和 药物中间体 [15] 的合成中. 而研究者近来又发现, 酶不仅 有专一性 [16] , 还具有非专一性 [17] , 即酶可以催化传统反 应 外 多 种 其 它 的 有 机 反 应 , 如 脂 肪 酶 [18] 可 以 催 化 Mannich 反应 [19] 、Aldol 反应 [20] 和 Knoevenagel 反应 [21] , 蛋白酶可以催化 Michael 加成反应 [22] 、Henry 反应 [23] 和 Friedländer 反应 [24] 等. 出于对酶非专一性研究的持续关 注, 本文以活性腈和 2,5-二羟基-1,4-二噻烷为原料, 通 过爪哇毛霉脂肪酶催化的 Gewald 反应, 合成了一系列 2-氨基噻吩类化合物(Eq.…”

Wealth from waste: M. acuminata peel waste-derived magnetic nanoparticles as a solid catalyst for the Henry reaction

“…The product 2-nitroalcohol can act as an intermediate in the formation of nitroalkenes, a-nitroketones, and b-amino alcohol derivatives, and synthesis of chiral ligands and some biologically active compounds. 1,2 It can also be easily transformed into other chiral building blocks by oxidation, reduction, the Nef reaction or a nucleophilic displacement reaction due to chemical versatility of the nitro group present in the product molecule. 3 Therefore, continuous efforts have been devoted to developing a simple and mild catalytic system for the Henry reaction.…”

Synthesis of Quinazolinone Derivatives Catalyzed by Alkaline Protease

“…[24] As efficient biocatalysts, enzymes help to carry out multi-functional non-natural reactions, [25] because of their catalytic promiscuity, which strongly facilitate their application in the realm of organic synthesis, such as aldol reactions, [26,27] Michael reactions, [28～31] Mannich reactions [32,33] and Henry reactions. [34,35] As a kind of protease, alkaline protease exhibits higher catalytic activities and selectivities in synthesis of heterocyclic compounds. [36～38] In order to extend the application of enzyme in more challenging organic synthesis, we envisioned that alkaline protease catalysis may provide a practical approach to directly accessing various functional quinazolinone derivatives.…”