Synthesis of Quinazolinone Derivatives Catalyzed by Alkaline Protease

Abstract

Alkaline protease-catalyzed synthesis of quinazolinone derivatives was developed between β-keotester and o-aminobenzamide. Because ethanol is one kind of eco-friendly solvents, this method can reduce the impact of solvents on the environment. Alkaline protease as a biocatalyst has many advantages, e.g. high catalytic activity, environmentally friendly, wide variety of sources and simple operation. In addition, a variety of quinazolinone derivatives was obtained with good to excellent yields just using 2000 U alkaline protease as catalyst.

Catalyst‐free synthesis of quinazolinones by oxidative cyclization under visible light in the absence of additives

“…From the viewpoint of green chemistry, the field of biocatalysis is attracting increasing attention. Enzymes are green and efficient biocatalysts [12], we have reported several studies on the synthesis of quinazolinone derivatives using pepsin [13], and alkaline [14] protease as catalysts. Thus, it is necessary to explore newer synthetic strategies for quinazolinones.…”

α-Chymotrypsin-Induced Acetalization of Aldehydes and Ketones with Alcohols

“…14 Additionally, it is the advantages of these enzymes that are frequently reported in organic reactions catalyzed by enzymes. [15][16][17][18][19][20] Due to the aforementioned properties possessed by enzymes, researchers are currently focusing on the combination of enzymes and conventional catalysts to develop organic reactions that cannot be achieved by a single catalyst, such as photoenzymatic ones. [21][22][23] As a well-studied hydrolase, -chymotrypsin has been demonstrated that it can keep its activity in organic solvents.…”