Database of processing techniques and processing factors compatible with the EFSA food classification and description system FoodEx 2 Objective 3: European database of processing factors for pesticides in food

Scholz, Rebekka; Donkersgoed, Gerda van; Herrmann, Michael; Kittelmann, Arno; Schledorn, Maria von; Graven, Coen; Mahieu, Karin; Velde-Koerts, Trijntje van der; Anagnostopoulos, Chris; Bempelou, Eleftheria; Michalski, Britta

doi:10.2903/sp.efsa.2018.en-1510

Cited by 43 publications

(66 citation statements)

References 16 publications

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“…Processing factors obtained or extrapolated from the European database on processing factors for pesticides in food (Scholz et al, 2018) CAG-TCP: cumulative assessment group of pesticides associated with hypertrophy, hyperplasia and neoplasia of C-cells; CAG-TCF: cumulative assessment group of pesticides associated with hypothyroidism; MRL: maximum residue level; LOQ: limit of quantification. *: Accounts for substances that are not part of the CAG and for residue definitions that are not exclusive (see Section 2.4.1.1)…”

Section: Processed Foodsmentioning

confidence: 99%

Cumulative dietary exposure assessment of pesticides that have chronic effects on the thyroid using SAS® software

Dujardin¹,

Bocca²

2019

EFS2

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Retrospective dietary exposure assessments were conducted for two groups of pesticides that have chronic effects on the thyroid: hypertrophy, hyperplasia and neoplasia of C-cells, and hypothyroidism. The pesticides considered in this assessment were identified and characterised in the scientific report on the establishment of cumulative assessment groups of pesticides for their effects on the thyroid. The exposure assessments used monitoring data collected by Member States under their official pesticide monitoring programmes in 2014, 2015 and 2016, and individual food consumption data from 10 populations of consumers from different countries and from different age groups. Exposure estimates were obtained for each group of pesticides by means of a 2-dimensional probabilistic model, which was implemented in SAS ® software. Results were validated against exposure estimates obtained by the Dutch National Institute for Public Health and the Environment (RIVM) using the Monte Carlo Risk Assessment (MCRA) software. Both tools produced nearly identical results and minor differences were mainly attributed to the random effect of probabilistic modelling. The exposure estimates obtained in this report are used in the final scientific report on the cumulative dietary risk characterisation of pesticides that have chronic effects on the thyroid. The latter combines the hazard assessment and exposure assessment into a consolidated risk characterisation including all uncertainties.

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Section: Processed Foodsmentioning

confidence: 99%

Cumulative dietary exposure assessment of pesticides that have chronic effects on the thyroid using SAS® software

Dujardin¹,

Bocca²

2019

EFS2

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“…The European database on processing factors is the most recent and the most comprehensive compilation of processing factors currently available at EU level (Scholz et al, 2018). Processing factors for the active substances and RPCs under assessment were extracted from the database according to the following criteria.…”

Section: Processing Factorsmentioning

confidence: 99%

Cumulative dietary exposure assessment of pesticides that have acute effects on the nervous system using SAS® software

Dujardin¹,

Bocca²

2019

EFS2

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Retrospective dietary exposure assessments were conducted for two groups of pesticides that have acute effects on the nervous system: brain and/or erythrocyte acetylcholinesterase inhibition, and functional alterations of the motor division. The pesticides considered in this assessment were identified and characterised in the scientific report on the establishment of cumulative assessment groups of pesticides for their effects on the nervous system. The exposure assessments used monitoring data collected by Member States under their official pesticide monitoring programmes in 2014, 2015 and 2016 and individual food consumption data from 10 populations of consumers from different countries and from different age groups. Exposure estimates were obtained for each group of pesticides by means of a 2-dimensional Monte Carlo simulation, which was implemented in SAS ® software. Results were validated against exposure estimates obtained by the Dutch National Institute for Public Health and the Environment (RIVM) using the Monte Carlo Risk Assessment (MCRA) software. Both tools produced nearly identical results and minor differences were mainly attributed to the random effect of probabilistic modelling. The exposure estimates obtained in this report are used in the final scientific report on the cumulative dietary risk characterisation of pesticides that have acute effects on the nervous system. The latter combines the hazard assessment and exposure assessment into a consolidated risk characterisation including all related uncertainties.

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“…In this respect processing factors are applied to each food commodity and active substance combination. A comprehensive European database of reliable processing factors for multiple active substances was recently published (Scholz et al, 2018) and should be applied in the framework of a combined risk assessment, even at Tier I level.…”

Section: 3mentioning

confidence: 99%

“…During the first part of the project, the objective was to understand and familiarise with the risk assessment procedures and European regulations of active substances and PPPs at European and national/zonal level. During the second part of the project, the aim was to assess the dietary exposure of the French population to multiple pesticides using the MCRA software while looking into the effect of processing factors by incorporating the newly published European database of processing factors for pesticides in food (Scholz et al, 2018) Integration in the projects and activities within the regulated products residue and consumer safety unit at ANSES was the core objective of the programme.…”

Section: Aimsmentioning

confidence: 99%

“…In view of refining and making more realistic the risk under evaluation, the effects of processing on the total residues have to be taken into account. The main objective of the current project was to incorporate in the analysis the processing factors published in the European food database (Scholz et al, 2018). The challenges arsing were (a) translating the processing factor data (provided in a FOODEX2 system) to a form compatible with the available concentration and consumption data currently used by France (FOODEX1) and (b) interpreting the results taking into consideration that actually very limited information on the specific combination of process and active substance within each food commodity is actually available.…”

Section: Combined Dietary Risk Assessment Of Multiple Pesticide Residuesmentioning

confidence: 99%

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Assessment of combined risk to pesticide residues through dietary exposure

Chatzidimitriou¹,

Mienne²,

Pierlot³

et al. 2019

EFS2

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Plant protection products (PPPs) are preparations intended to protect plants and their products including one or more active substances. The use of PPPs may cause direct or indirect risks. Residues that can remain in or on food might pose a danger to human health through consumption and acute or/and chronic exposure. Authorisation of active substances and PPPs are decided at European and national level, respectively. Risk assessment of dietary exposure to residues of PPPs is regulated by a very extensive legal framework, ensuring consumer safety. The review and evaluation of the residue section of active substance monographs and the dossiers for PPP authorisations within the French Agency for Food, Environmental and Occupational Health & Safety (ANSES) helped gain hands‐on experience on food risk assessment, as previewed in the framework of the European Food Risk Assessment Fellowship Programme (EU‐FORA). The programme also focused on the cumulative effects of acute exposure to pesticides in food on the human nervous system using probabilistic methodology and it was in continuation of the work carried out by ANSES and the regulated products department residue unit. Using the European Database for processing factors for pesticides in food was one of the main challenges in order to approach a more realistic scenario of exposure. The probabilistic methodology followed was used in accordance with the European Food Safety Authority harmonised guidance.

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Database of processing techniques and processing factors compatible with the EFSA food classification and description system FoodEx 2 Objective 3: European database of processing factors for pesticides in food

Cited by 43 publications

References 16 publications

Cumulative dietary exposure assessment of pesticides that have chronic effects on the thyroid using SAS® software

Cumulative dietary exposure assessment of pesticides that have chronic effects on the thyroid using SAS® software

Cumulative dietary exposure assessment of pesticides that have acute effects on the nervous system using SAS® software

Assessment of combined risk to pesticide residues through dietary exposure

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