Data representation and reduction for chromatin texture in nuclei from premalignant prostatic, esophageal, and colonic lesions

Weyn, Barbara; Jacob, W.; Silva, Vinícius Duval da; Montironi, Rodolfo; Hamilton, Peter; Thompson, Deborah; Bartels, Hubert G.; Daele, Andréle Van; Dillon, Katrina; Bartels, Peter H.

doi:10.1002/1097-0320(20001001)41:2<133::aid-cyto8>3.3.co;2-n

Cited by 10 publications

(11 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In malignancy, there are dramatic changes in chromatin appearance. Promising examples, for the value of nuclear texture feature measurement in the classification and detection of malignancy‐associated changes (MAC) in a variety of human tissues, including prostatic, colonic and oesophageal lesions, have been established [38].…”

Section: Discussionmentioning

confidence: 99%

Epigenetic events, remodelling enzymes and their relationship to chromatin organization in prostatic intraepithelial neoplasia and prostatic adenocarcinoma

et al. 2007

Self Cite

View full text Add to dashboard Cite

immunodensity was measured using DIA to determine the epigenetic profile of the cases. At least 60 nuclei were measured from each case. RESULTSThere were many statistically significant differences in staining intensity and nuclear distribution patterns in chromatin phenotype and immunostaining ( p ≤ 0.001). These changes allowed the differentiation between the various pathological subgroups with a classification accuracy of 76-100% using chromatin phenotype or immunostaining measuring epigenetic and chromatin remodelling changes (5MeC, AcH3K9 and ISWI). In PIN lesions, there was a high chromatin content with DNAhypermethylation, while in prostatic adenocarcinoma there was a lower chromatin content with DNA-hypomethylation and H3K9-hypoacetylation. There was significantly more ISWI protein in neoplastic tissues. There were malignancy-associated changes (MAC) in chromatin phenotype and overall epigenetic events in BPH tissues adjacent to PIN lesions. CONCLUSIONSThe present study confirms the ability of highresolution computerized digital imaging of nuclear texture features to detect changes in chromatin phenotype, epigenetic events and the presence of chromatin remodelling, factors that can be used to distinguish between different prostatic pathologies, i.e. BPH, LGPIN, HGPIN and prostate adenocarcinoma, and further allow the detection of MAC near PIN lesions. These results provide a base for future diagnostic applications of DIA combined with immunohistochemistry. Our experiments underscore the importance of epigenetic mechanisms during carcinogenesis. Further studies are needed to elucidate the complex interplay between chromatin structure, its modifications and the progression of prostate cancer.

show abstract

Section: Discussionmentioning

confidence: 99%

Epigenetic events, remodelling enzymes and their relationship to chromatin organization in prostatic intraepithelial neoplasia and prostatic adenocarcinoma

et al. 2007

Self Cite

View full text Add to dashboard Cite

show abstract

“…Alterations in chromatin texture reflect quantitative or qualitative changes in DNA content and structure 755. Digital image analysis provides a variety of measures of chromatin texture, including chromatin intensity, heterogeneity, condensation, margination, run‐length nonuniformity, long‐run emphasis, gray‐level nonuniformity, and inertia.…”

Section: 0 Goalsmentioning

confidence: 99%

Human prostate cancer risk factors

Bostwick

Burke

Djakiew

et al. 2004

Cancer

510

359

View full text Add to dashboard Cite

“…Weyn et al successfully applied different textural descriptors, including co-occurrence matrix-based and run-length matrix-based parameters, to assess nuclear dysplasia in colonic, esophageal, and prostatic premalignant epithelia lesions (25). Co-occurrence matrix-and run-length matrixbased parameters are good for the characterization of healthy and pathological human cerebral tissues on MRI (13,14).…”

Section: Discussionmentioning

confidence: 99%

Differentiation of Diffuse Large B-cell Lymphoma From Follicular Lymphoma Using Texture Analysis on Conventional MR Images at 3.0 Tesla

Sikiö

Pertovaara

et al. 2016

Academic Radiology

View full text Add to dashboard Cite

Data representation and reduction for chromatin texture in nuclei from premalignant prostatic, esophageal, and colonic lesions

Abstract: Image analysis and subsequent data reduction of nuclear signatures of contour features is a novel method, providing quantitative information that may lead to an effective identification of nuclei and lesions.

Cited by 10 publications

References 2 publications

Epigenetic events, remodelling enzymes and their relationship to chromatin organization in prostatic intraepithelial neoplasia and prostatic adenocarcinoma

Epigenetic events, remodelling enzymes and their relationship to chromatin organization in prostatic intraepithelial neoplasia and prostatic adenocarcinoma

Human prostate cancer risk factors

Differentiation of Diffuse Large B-cell Lymphoma From Follicular Lymphoma Using Texture Analysis on Conventional MR Images at 3.0 Tesla

Contact Info

Product

Resources

About