Data on the effects of Glochidion zeylanicum leaf extracts in Caenorhabditis elegans

Abstract

The present article contains the data on the effects of Glochidion zeylanicum leaf extracts in C. elegans, which is related to the article " Glochidion zeylanicum leaf extracts exhibit lifespan extending and oxidative stress resistance properties in Caenorhabditis elegans via DAF-16/FoxO and SKN-1/Nrf-2 signaling pathways" Chatrawee et al., 2019. This dataset was generated to better understand the antioxidant and anti-aging properties of G. zeylanicum leaf extracts in C. elegans. The bioactive compounds of the extracts were analyzed using GLC-MS, LC-MS, and RP-HPLC. The antioxidant properties were determined using phenolics, flavonoids, ABTS and DPPH assays. The in vivo antioxidant properties were performed using the intracellular ROS accumulation and the survival rate under oxidative stress condition assays. The brood size, body length and life-span were determined regarding anti-aging properties in this data.

Neuroprotective Effects of Glochidion zeylanicum Leaf Extract against H2O2/Glutamate-Induced Toxicity in Cultured Neuronal Cells and Aβ-Induced Toxicity in Caenorhabditis elegans

“…Several studies have reported that polyphenols, including gallic acid [ 32 , 34 ], catechin [ 13 , 40 , 41 ] and quercetin [ 33 , 42 , 43 ], promote neurite outgrowth activity. The presence of phenolic compounds as well as gallic acid, catechin, and quercetin in GZM extract may be responsible for the observed behavior ( Supplementary Figure S1 ) [ 11 , 12 ].…”

“…Several studies have reported that phenolic antioxidants can protect against neurotoxicity induced by glutamate, Aβ peptides, and oxidative stress, which mainly depends on Nrf2/ARE signaling pathways [ 13 , 17 , 49 , 50 , 51 , 52 ]. GZM extract contains phenolic compounds including gallic acid, catechin, and quercetin ( Supplementary Figure S1 ) [ 11 , 12 ]. Thus, neuroprotective effects mediated by the SIRT1/Nrf2 signaling pathway may result from the presence of bioactive compounds in the GZM extract.…”

“…All of the C. elegans strains used in the study were procured from Caenorhabditis Genetics Center (University of Minnesota, U.S.A.) and maintained with Escherichia coli OP50 as the food source [ 16 ]. The nematodes were cultured in NGM agar plates at 16 °C and synchronized populations were developed as described previously [ 7 , 12 ]. Strains used in this study include CL4176 (smg-1(cc546) I; dvIs27 [(myo-3p::A-Beta (1–42)::let-851 3′UTR) + rol-6(su1006)] X), CL2006 (dvIs2 [pCL12(unc-54/human Abeta peptide 1–42 minigene) + pRF4]), CL2355 (smg-1(cc546) dvIs50 [pCL45 (snb-1::Abeta 1–42::3′ UTR(long) + mtl-2::GFP] I), and CL2122 (dvIs15 [(pPD30.38) unc-54(vector) + (pCL26) mtl-2::GFP.…”

“…In our previous study, the leaf extract of GZ was shown to promote oxidative stress resistance and exhibit anti-aging effects in the nematode Caenorhabditis elegans through the DAF-16/FoxO and SKN-1/Nrf-2 signaling pathways. [ 11 , 12 ]. Nevertheless, neuroprotective and neuritogenesis properties of GZ extract have not been reported.…”

In vitro study of antioxidant and antibacterial properties of Phyllanthaceae and Rubiaceae plant families from Simeuleu Island, Aceh, Indonesia

“…from Simeulue, Aceh, Indonesia. G. zeylanicum is known to have potential as anti-tumor, anti-cancer, antioxidant and anti-aging agents (Duangjan et al, 2019;Sharma et al, 2011;Tanaka et al, 2004). Meanwhile, U. cordata has anti-hyperglycemic and antimicrobe antivities (Abdullah, 2016;Syafriana et al, 2021).…”