Data on global analysis of clinical trials with probiotics

Dronkers, Theresia M.G.; Ouwehand, Arthur C.; Rijkers, Ger T.

doi:10.1016/j.dib.2020.106269

Cited by 6 publications

(2 citation statements)

References 6 publications

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“…Different aspects of digestive health are the most common health benefits addressed by probiotics ( 103 ). The above review has shown that also B. lactis HN019™ has several health benefits in this area, in particular in the area of bowel function and intestinal motility.…”

Section: Discussionmentioning

confidence: 99%

Bifidobacterium animalis subsp. lactis HN019 Effects on Gut Health: A Review

Cheng¹,

Laitila²,

Ouwehand³

2021

Front. Nutr.

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Optimal gut motility is central to bowel function and gut health. The link between the gut dysmotility related disorders and dysfunctional-intestinal barriers has led to a hypothesis that certain probiotics could help in normalizing gut motility and maintain gut health. This review investigates the roles of Bifidobacterium animalis subsp. lactis HN019 (B. lactis HN019™) on gut health, and its mechanisms of action in various pre-clinical and clinical studies. Research supports the hypothesis that B. lactis HN019™ has a beneficial role in maintaining intestinal barrier function during gastrointestinal infections by competing and excluding potential pathogens via different mechanisms; maintaining normal tight junction function in vitro; and regulating host immune defense toward pathogens in both in vitro and human studies. This has been observed to lead to reduced incidence of diarrhea. Interestingly, B. lactis HN019™ also supports normal physiological function in immunosenescent elderly and competes and excludes potential pathogens. Furthermore, B. lactis HN019™ reduced intestinal transit time and increased bowel movement frequency in functional constipation, potentially by modulating gut–brain–microbiota axis, mainly via serotonin signaling pathway, through short chain fatty acids derived from microbial fermentation. B. lactis HN019™ is thus a probiotic that can contribute to relieving gut dysmotility related disorders.

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Section: Discussionmentioning

confidence: 99%

Bifidobacterium animalis subsp. lactis HN019 Effects on Gut Health: A Review

Cheng¹,

Laitila²,

Ouwehand³

2021

Front. Nutr.

Self Cite

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“…Probiotics provide a broad range of health benefits; however, when a personal healthcare regime is implemented clinically, it poses certain constraints regarding the availability of experimental data. 130 Host nonresponsiveness to probiotics is also a significant concern, with differential outcomes reported to probiotic-based intervention. 43 For example, in a Canadian study, only 36% of diarrhea patients showed a positive response to the probiotics therapy, while 64% did not show any response.…”

Section: Challenges and Opportunities Of Precision Probiotics Develop...mentioning

confidence: 99%

The Potential of Meta-Proteomics and Artificial Intelligence to Establish the Next Generation of Probiotics for Personalized Healthcare

Das,

Behera,

Kapoor

et al. 2023

J. Agric. Food Chem.

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The symbiosis of probiotic bacteria with humans has rendered various health benefits while providing nutrition and a suitable environment for their survival. However, the probiotics must survive unfavorable gut conditions to exert beneficial effects. The intrinsic resistance of probiotics to survive harsh conditions results from a myriad of proteins. Interaction of microbial proteins with the host is indispensable for modulating the gut microbiome, such as interaction with cell receptors and protective action against pathogens. The complex interplay of proteins should be unraveled by utilizing metaproteomic strategies. The contribution of probiotics to health is now widely accepted. However, due to the inconsistency of generalized probiotics, contemporary research toward precision probiotics has gained momentum for customized treatment. This review explores the application of metaproteomics and AI/ML algorithms in resolving multiomics data analysis and in silico prediction of microbial features for screening specific beneficial probiotic organisms. Implementing these integrative strategies could augment the potential of precision probiotics for personalized healthcare.

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Probiotics as potential treatments to reduce myocardial remodelling and heart failure via the gut-heart axis: State-of-the-art review

Karmazyn

Gan

2023

Mol Cell Biochem

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Data on global analysis of clinical trials with probiotics

Cited by 6 publications

References 6 publications

Bifidobacterium animalis subsp. lactis HN019 Effects on Gut Health: A Review

Bifidobacterium animalis subsp. lactis HN019 Effects on Gut Health: A Review

The Potential of Meta-Proteomics and Artificial Intelligence to Establish the Next Generation of Probiotics for Personalized Healthcare

Probiotics as potential treatments to reduce myocardial remodelling and heart failure via the gut-heart axis: State-of-the-art review

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