Data Mining in Bioinformatics (BIOKDD)

Zaki, Mohammed J.; Karypis, George; Yang, Jiong

doi:10.1186/1748-7188-2-4

Cited by 5 publications

(1 citation statement)

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“…In this paper simple mining techniques ( Yao et al, 2009 ; Zaki et al, 2007 ) have been used to look at the Humanin gene in the mitochondrial sequences of the human and other vertebrates available in the GenBank database. The study showed that pseudogenization of the Humanin gene does not occur in the human, but is a common feature in other vertebrates.…”

Section: Introductionmentioning

confidence: 99%

Humanin基因的假基因化普遍存在于若干脊椎动物的线粒体DNA中

Logan¹

2017

Zool. Res.

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In the human the peptide Humanin is produced from the small Humanin gene which is embedded as a gene-within-a-gene in the 16S ribosomal molecule of the mitochondrial DNA (mtDNA). The peptide itself appears to be significant in the prevention of cell death in many tissues and improve cognition in animal models. By using simple data mining techniques, it is possible to show that 99.4% of the human Humanin sequences in the GenBank database are unaffected by mutations. However, in other vertebrates, pseudogenization of the Humanin gene is a common feature; occurring apparently randomly in some species and not others. The persistence, or loss, of a functional Humanin gene may be an important factor in laboratory animals, especially if they are being used as animal models in studies of Alzheimer's disease (AD). The exact reason why Humanin underwent pseudogenization in some vertebrate species during their evolution remains to be determined. This study was originally planned to review the available information about Humanin and it was a surprise to be able to show that pseudogenization has occurred in a gene in the mtDNA and is not restricted solely to chromosomal genes.

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Section: Introductionmentioning

confidence: 99%