Data for the cytotoxicity, self-assembling properties and synthesis of 4-pyridinium-1,4-dihydropyridines

Abstract

In this data file the synthetic procedures for preparation of the original 4-pyridinium-1,4-dihydropyridines (4-Py-1,4-DHP) and their parent compounds – dialkyl 2,6-dimethyl-4-(3-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylates were described. In total, 5 unpublished compounds were obtained and characterised. All the structures of original compounds were confirmed by Nuclear Magnetic Resonance (NMR, including 1 H NMR and 13 C NMR) and low resolution mass spectra (MS) data. Additionally, the cytotoxic properties of four 4-Py-1,4-DHPs were evaluated on 3 cell lines – normal NIH3T3 (mouse embryonic fibroblast), cancerous HT-1080 (human lung fibrosarcoma) and MH-22A (mouse hepatoma) and self-assembling properties were studied and characterisation of formed nanoparticles were performed using dynamic light scattering technique. In this article provided data are directly related to the previously published research articles – “Novel cationic amphiphilic 1,4-dihydropyridine derivatives for DNA delivery” [1] where compound 5 was tested as gene delivery agent without full physico-chemical characterisation and “Synthesis and studies of calcium channel blocking and antioxidant activities of novel 4-pyridinium and/or N-propargyl substituted 1,4-dihydropyridine derivatives” [2] where synthesis and physico-chemical characterisation as well as calcium channel blocking and antioxidant activities were described for compound 6. Synthesis of other compounds – parent 1,4-DHPs 1 and 2, and 4-Py-1,4-DHPs 3–5, their characterisation, estimation of cytotoxicity and self-assembling properties for all 4-Py-1,4-DHPs 3–6 are reported herein for the first time. Information provided in this data file can be used in medicinal chemistry by other scientists to estimate structure-activity relationships for the analysis and construction of various cationic 1,4-dihydropyridine derivatives and related heterocycles.

Pharmacological importance of novel spiro derivatives against human pathogenic fungi

“…DHPs' analogy with 1,4-dihydronicotinamide has theorized its possible use in studying the molecular mechanisms as model compounds. They are postulated for providing the base for newer cardiovascular drugs development [8,9]. A number of drugs commonly used in present times bear the 1,4-DHP ring-like calcium channel blockers [10][11][12].…”

Demulsification of Heavy Petroleum Emulsion Using Pyridinium Ionic Liquids with Distinct Anion Branching

“…ILs are highly preferred to other chemical demulsifiers because of their unique characteristics, such as moderate ionic conductivity, lower vapor pressure, high chemical stability, and lower flammability . Numerous studies elucidating the effectiveness of ILs for demulsification activity of water/oil separation have been reported in the literature. − Pyridinium is a new class of ILs with unique features and has been tested for many scientific applications. − Specifically, pyridinium ILs are attracting considerable attention as demulsifying chemicals for stable emulsions. Recently, Atta et al synthesized novel geminal dicationic ILs composed of pyridinium and imidazolium cations for the purpose of demulsifying heavy emulsions produced from seawater and crude oil.…”