Data acquisition unit for an implantable multi-channel optical glucose sensor

Kanukurthy, K.S.; Cover, Mathew; Andersen, David R.

doi:10.3233/ica-2008-15203

Cited by 1 publication

(1 citation statement)

References 6 publications

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“…The availability of a reliable long-term blood glucose level (BGL) sensor would have a disruptive impact on healthcare and diabetes management, considering that over 5% of the world's population suffers from diabetes [9] and this number is increasing rapidly [10]. Wireless electronic systems have been suggested for amperometric [11], [12] and near-infrared spectroscopy based [13] glucose sensors. However, problems with existing continuous BGL monitors have encouraged alternative approaches to glucose sensing [14].…”

Section: Wireless Implantable Electronic Platform For Chronicmentioning

confidence: 99%

Wireless Implantable Electronic Platform for Chronic Fluorescent-Based Biosensors

Valdastri

Susilo

Forster

et al. 2011

IEEE Trans. Biomed. Eng.

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Abstract-The development of a long-term wireless implantable biosensor based on fluorescence intensity measurement poses a number of technical challenges, ranging from biocompatibility to sensor stability over time. One of these challenges is the design of a power efficient and miniaturized electronics, enabling the biosensor to move from bench testing to long term validation, up to its final application in human beings. In this spirit, we present a wireless programmable electronic platform for implantable chronic monitoring of fluorescent-based autonomous biosensors. This system is able to achieve extremely low power operation with bidirectional telemetry, based on the IEEE802.15.4-2003 protocol, thus enabling over three-year battery lifetime and wireless networking of multiple sensors. During the performance of single fluorescent-based sensor measurements, the circuit drives a laser diode, for sensor excitation, and acquires the amplified signals from four different photodetectors. In vitro functionality was preliminarily tested for both glucose and calcium monitoring, simply by changing the analyte-binding protein of the biosensor. Electronics performance was assessed in terms of timing, power consumption, tissue exposure to electromagnetic fields, and in vivo wireless connectivity. The final goal of the presented platform is to be integrated in a complete system for blood glucose level monitoring that may be implanted for at least one year under the skin of diabetic patients. Results reported in this paper may be applied to a wide variety of biosensors based on fluorescence intensity measurement.Index Terms-Biotelemetry, calcium sensing, chronic implants, fluorescence-based biosensor, fluorescence resonant energy transfer (FRET), glucose monitoring, implantable devices.

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