Das Wachstumsfaktorkomposit aus GDF-5 und mineralisiertem Kollagen verbessert die Ausheilung einer H�ftkopfnekrose

Simank, H.-G.; Herold, Falko; Schneider, M.; Maedler, U.; Ries, Rainer; Sergi, Consolato

doi:10.1007/s00132-003-0541-z

Cited by 12 publications

(4 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The first experimental studies have shown that GDF-5 is involved in the growth of all skeletal tissues. Thus GDF-5 has improved ligament healing (Aspenberg and Forslung, 1999;Tashiro et al, 2006), cartilage growth (Simank et al, 2004a) and (Spiro et al, 2001;Jahng et al, 2004;Simank et al, 2004b). The effect of recombinant human growth differentiation factor 5 (rhGDF-5) on membranous bone formation has been demonstrated recently by in vivo studies (Yoshimoto et al, 2006;Poehling et al, 2006).…”

Section: Discussionmentioning

confidence: 94%

A preliminary report on the effect of dimeric rhGDF-5 and its monomeric form rhGDF-5C465A on bone healing of rat cranial defects

Dupoirieux

Pohl

Hanke

et al. 2009

Journal of Cranio-Maxillofacial Surgery

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 94%

A preliminary report on the effect of dimeric rhGDF-5 and its monomeric form rhGDF-5C465A on bone healing of rat cranial defects

Dupoirieux

Pohl

Hanke

et al. 2009

Journal of Cranio-Maxillofacial Surgery

View full text Add to dashboard Cite

“…In addition, HA particles coated with 5 µg GDF-5 were more effective than those coated with 10 µg BMP-2 [ 49 ]). Although local release of the two BMPs in any of these different bone sites may be different, GDF-5 or its mutant BB-1 may thus still represent a valid option for bone replacement surgery [ 17 , 24 , 26 , 67 – 70 ].…”

Section: Discussionmentioning

confidence: 99%

BMP-2 (and partially GDF-5) coating significantly accelerates and augments bone formation close to hydroxyapatite/tricalcium-phosphate/brushite implant cylinders for tibial bone defects in senile, osteopenic sheep

Sachse

Hasenbein

Hortschansky

et al. 2023

J Mater Sci: Mater Med

View full text Add to dashboard Cite

Bilateral defects (diameter 8 mm) in the medial tibial head of senile, osteopenic female sheep (n = 48; 9.63 ± 0.10 years; mean ± SEM) were treated with hydroxyapatite (HA)/beta-tricalcium phosphate (β-TCP)/dicalcium phosphate dihydrate (DCPD; brushite) cylinders coated with BMP-2 (25 or 250 micrograms) or growth differentiation factor (GDF)-5 (125 or 1250 micrograms; left side); cylinders without BMP served as controls (right side). Three, 6, and 9 months post-operation (n = 6 each group), bone structure and formation were analyzed in vivo by X-ray and ex vivo by osteodensitometry, histomorphometry, and micro-computed tomography (micro-CT) at 3 and 9 months. Semi-quantitative X-ray evaluation showed significantly increasing bone densities around all implant cylinders over time. High-dose BMP-2-coated cylinders (3 and 9 months) and low-dose GDF-5-coated cylinders (3 and 6 months) demonstrated significantly higher densities than controls (dose-dependent for BMP-2 at 3 months). This was confirmed by osteodensitometry at 9 months for high-dose BMP-2-coated cylinders (and selected GDF-5 groups), and was again dose-dependent for BMP-2. Osteoinduction by BMP-2 was most pronounced in the adjacent bone marrow (dynamic histomorphometry/micro-CT). BMP-2 (and partially GDF-5) significantly increased the bone formation in the vicinity of HA/TCP/DCPD cylinders used to fill tibial bone defects in senile osteopenic sheep and may be suitable for surgical therapy of critical size, non-load-bearing bone defects in cases of failed tibial head fracture or defect healing. Graphical Abstract

show abstract

“…When the same animal model was used, BMP-14-loaded, hydroxyapatite-coated collagen scaffolds (Healos; DePuy, Warsaw, IN, USA) significantly improved bony remodeling of the necrotic area. In comparison, when the scaffold was applied without BMP-14, only partial defect filling with mainly fibrous tissue and persistence of the necrosis was seen after 12 weeks [34]. …”

Section: Growth Factor-based Strategiesmentioning

confidence: 99%

Stem cell- and growth factor-based regenerative therapies for avascular necrosis of the femoral head

Rackwitz¹,

Eden²,

Reppenhagen³

et al. 2012

Stem Cell Res Ther

View full text Add to dashboard Cite

Avascular necrosis (AVN) of the femoral head is a debilitating disease of multifactorial genesis, predominately affects young patients, and often leads to the development of secondary osteoarthritis. The evolving field of regenerative medicine offers promising treatment strategies using cells, biomaterial scaffolds, and bioactive factors, which might improve clinical outcome. Early stages of AVN with preserved structural integrity of the subchondral plate are accessible to retrograde surgical procedures, such as core decompression to reduce the intraosseous pressure and to induce bone remodeling. The additive application of concentrated bone marrow aspirates, ex vivo expanded mesenchymal stem cells, and osteogenic or angiogenic growth factors (or both) holds great potential to improve bone regeneration. In contrast, advanced stages of AVN with collapsed subchondral bone require an osteochondral reconstruction to preserve the physiological joint function. Analogously to strategies for osteochondral reconstruction in the knee, anterograde surgical techniques, such as osteochondral transplantation (mosaicplasty), matrix-based autologous chondrocyte implantation, or the use of acellular scaffolds alone, might preserve joint function and reduce the need for hip replacement. This review summarizes recent experimental accomplishments and initial clinical findings in the field of regenerative medicine which apply cells, growth factors, and matrices to address the clinical problem of AVN.

show abstract

Das Wachstumsfaktorkomposit aus GDF-5 und mineralisiertem Kollagen verbessert die Ausheilung einer H�ftkopfnekrose

Abstract: The application of an absorbable GDF-5 composite in combination with a core decompression procedure may enhance the healing of devitalized bone defects and is a promising approach for further studies.

Cited by 12 publications

References 19 publications

A preliminary report on the effect of dimeric rhGDF-5 and its monomeric form rhGDF-5C465A on bone healing of rat cranial defects

A preliminary report on the effect of dimeric rhGDF-5 and its monomeric form rhGDF-5C465A on bone healing of rat cranial defects

BMP-2 (and partially GDF-5) coating significantly accelerates and augments bone formation close to hydroxyapatite/tricalcium-phosphate/brushite implant cylinders for tibial bone defects in senile, osteopenic sheep

Stem cell- and growth factor-based regenerative therapies for avascular necrosis of the femoral head

Contact Info

Product

Resources

About