Das Schmidt-Syndrom

Stahn, Bonnie; Scheit, Lorenz

doi:10.1055/a-0875-4538

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…An example confirming the increased risk of developing another autoimmune disease is the case described by Bonnie Stahn et al [17]. A 22-year-old man visited his doctor because of exhaustion, changes in skin colour, and significant weight loss.…”

Section: Discussionmentioning

confidence: 89%

Schmidt syndrome – is it easy to recognize? Case report

Kozioł¹,

Obel²,

Krasa³

et al. 2022

Med Og Nauk Zdr.

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Introduction. Schmidt›s syndrome is one of the APS-2 variants, occurring with the frequency of 1.5-4.5 / 100,000, diagnosed approximately twice as often in women. Family occurrence is observed. Schmidt›s syndrome is found in the form of Addison›s disease and autoimmune thyroid disease. The units that make up the syndrome can appear in any order and time, and overlapping symptoms make diagnosis difficult. Case Report. A 39-year-old patient with hypothyroidism and impending adrenal crisis was admitted to the Endocrinology Department for hormonal evaluation. In the history of about a year, weight loss of 20 kg, lack of appetite, weakness, hypotonia, slightly darker skin with a large number of freckles. Second amenorrhea for a year and symptoms of depression. Two weeks earlier, the patient was hospitalized in the neurology department due to confusion, hyponatremia and cerebral edema found on CT. Symptoms after administration of mannitol and hydrocortisone resolved. Moreover, the abdominal CT scan revealed hypotrophic adrenal glands. In the Department of Endocrinology, a low concentration of morning cortisol was confirmed with a high level of ACTH (1623 pg / ml), which allowed confirmation of the diagnosis of Addison's disease. In addition, Hashimoto's disease was found. The coexistence of both diseases allowed the diagnosis of Schmidt's syndrome. Conclusions. The probability that a patient with one autoimmune disease will be diagnosed with another entity from the autoimmune spectrum is very high. The presented patient had typical symptoms of adrenal insufficiency, but they were associated with malnutrition, hypothyroidism and depression. Often, the symptoms of Addison's disease are masked by hypothyroidism, which makes diagnosis difficult.

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Section: Discussionmentioning

confidence: 89%

Schmidt syndrome – is it easy to recognize? Case report

Kozioł¹,

Obel²,

Krasa³

et al. 2022

Med Og Nauk Zdr.

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“…El síndrome poliglandular autoinmune tipo II (APS2) o también denominado síndrome Schmidt, representa una condición médica rara (1). Fue descrita por primera vez en 1926 por Schmidt, su prevalencia a nivel mundial es de 1,4-4,5 casos por cada 100000 habitantes (2).…”

Section: Introduciónunclassified

Síndrome Poliglandular Autoinmune Tipo II: Reporte de Caso

et al. 2023

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Resumen: El síndrome poliglandular autoinmune tipo II, constituye una rareza clínica y compleja debido a que causa la insuficiencia de dos o más glándulas endocrinas y daños a órganos no endocrinos, lo que la convierte en una condición grave, de la cual, hasta la actualidad no se conoce completamente su causa, sin embargo, su etiopatogenia se centra en factores autoinmunes y genéticos, es difícil de diagnosticar por la falta de información y de un protocolo estandarizado, las manifestaciones clínicas dependen de la glándula afectada, requiere un tratamiento complejo y cuyo manejo inadecuado puede derivar en la muerte del paciente. Es por ello, la relevancia de la presentación de este reporte de caso.Se trata de una paciente femenina de 69 años de nacionalidad ecuatoriana, quien cuenta con antecedentes de gastritis, osteoporosis y artrosis, acude a centro médico por presentar hiperpigmentación de piel y mucosas, es referida al departamento de endocrinología donde se le solicita valores de hormona adrenocorticotropa, los resultados mostraron una hormona adrenocorticotropa elevada, se llega al diagnóstico de una Enfermedad de Addison por clínica y datos de laboratorio, años después es diagnosticada de tiroiditis de Hashimoto, por lo que se sospechó de un síndrome poliglandular autoinmune tipo II, por la asociación de estas dos patologías, se corroboró el diagnóstico y se realizó el seguimiento terapéutico correspondiente. La relevancia del caso radica en su baja incidencia y en el proceso diagnóstico, sospechado en el contexto de una patología ajena a la patología autoinmune endocrina de base. Palabras Clave: Enfermedad de Addison, Enfermedad Autoinmune, Enfermedad de Hashimoto, Poliendocrinopatías Autoinmunes, Reporte de caso.

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Das Schmidt-Syndrom

Cited by 2 publications

References 15 publications

Schmidt syndrome – is it easy to recognize? Case report

Schmidt syndrome – is it easy to recognize? Case report

Síndrome Poliglandular Autoinmune Tipo II: Reporte de Caso

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