Das revidierte Kölner Apraxie-Screening (KAS-R) als diagnostisches Verfahren für Patienten mit rechtshemisphärischem Schlaganfall

Wirth, K; Held, A.; Kalbe, Elke; Kessler, Josef; Saliger, Jochen; Karbe, H.; Fink, Gereon R.; Weiss, Peter H.

doi:10.1055/s-0042-115843

Cited by 8 publications

(4 citation statements)

References 3 publications

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“…Several validated screening as well as diagnostic tests are now available to identify limb apraxia in stroke patients. Apraxia screening tests include the Cologne Apraxia Task, 74 the Florida Apraxia Test, 75 the Dementia Apraxia Test, 76 and the apraxia screening from the Boston Diagnostic Aphasia Examination. 77 There are shorter and more detailed and validated apraxia diagnostic tasks in the Test of Upper Limb Apraxia, 78 and apraxia testing within the Birmingham Cognitive Screening.…”

Section: Screening Tests For Apraxiamentioning

confidence: 99%

Limb Apraxias: The Influence of Higher Order Perceptual and Semantic Deficits in Motor Recovery After Stroke

Rounis

Binkofski

2023

Stroke

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Stroke is a leading cause of disability worldwide. Limb apraxia is a group of higher order motor disorders associated with greater disability and dependence after stroke. Original neuropsychology studies distinguished separate brain pathways involved in perception and action, known as the dual stream hypothesis. This framework has allowed a better understanding of the deficits identified in Limb Apraxia. In this review, we propose a hierarchical organization of this disorder, in which a distinction can be made between several visuomotor pathways that lead to purposeful actions. Based on this, executive apraxias (such as limb kinetic apraxia) cause deficits in executing fine motor hand skills, and intermediate apraxias (such as optic ataxia and tactile apraxia) cause deficits in reaching to grasp and manipulating objects in space. These disorders usually affect the contralesional limb. A further set of disorders collectively known as limb apraxias include deficits in gesture imitation, pantomime, gesture recognition, and object use. These deficits are due to deficits in integrating perceptual and semantic information to generate complex movements. Limb apraxias are usually caused by left-hemisphere lesions in right-handed stroke patients, affecting both limbs. The anterior- to posterior-axis of brain areas are disrupted depending on the increasing involvement of perceptual and semantic processes with each condition. Lower-level executive apraxias are linked to lesions in the frontal lobe and the basal ganglia, while intermediate apraxias are linked to lesions in dorso-dorsal subdivisions of the dorsal fronto-parietal networks. Limb apraxias can be caused by lesions in both dorsal and ventral subdivisions including the ventro-dorsal stream and a third visuomotor pathway, involved in body schema and social cognition. Rehabilitation of these disorders with behavioral therapies has aimed to either restore perceptuo-semantic deficits or compensate to overcome these deficits. Further studies are required to better stratify patients, using modern neurophysiology and neuroimaging techniques, to provide targeted and personalized therapies for these disorders in the future.

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Section: Screening Tests For Apraxiamentioning

confidence: 99%

Limb Apraxias: The Influence of Higher Order Perceptual and Semantic Deficits in Motor Recovery After Stroke

Rounis

Binkofski

2023

Stroke

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“…The Cologne Apraxia Screening (KAS) was performed to characterize apraxia deficits in several categories including imitation of gestures, pantomime of tool use, and gesture recognition (Latarnik et al, 2022; Wirth et al, 2016). The Dementia Apraxia Screen Test (DATE) is a screening tool specifically designed to assess apraxia in individuals with dementia (Johnen et al, 2018).…”

Section: Methodsmentioning

confidence: 99%

“…To test these hypotheses, we aimed to systematically assess apraxia in a well-defined group of patients with AD and correlate the results with data derived from tau-PET imaging in these individuals. To this end, we recruited a group of biomarker-confirmed patients with AD, who had been thoroughly characterized by neuropsychological assessment including systematic apraxia profiling using the Dementia Apraxia Test (DATE; (Johnen et al, 2018)) and the Cologne Apraxia Screening (KAS; (Latarnik et al, 2022; Wirth et al, 2016)). To reduce heterogeneity in the data, we planned to focus on patients with classical limb apraxia (deficits in gesture, imitation, pantomime, and actual object use), excluding other forms such as speech or gait apraxia.…”

Section: Introductionmentioning

confidence: 99%

Cortical Tau Aggregation Patterns associated with Apraxia in Alzheimer‘s Disease

Bischof,

Jaeger,

Giehl

et al. 2024

Preprint

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ObjectivesApraxia is a core feature of Alzheimer’s disease, but the pathomechanism of this characteristic symptom is not well understood. Here, we systematically investigated apraxia profiles in a well-defined group of patients with Alzheimer’s disease (AD; N=32) who additionally underwent PET imaging with the second-generation tau PET tracer [18F]PI-2620. We hypothesized that specific patterns of tau pathology might be related to apraxic deficits.MethodsPatients (N=32) with a biomarker-confirmed diagnosis of Alzheimer’s disease were recruited in addition to a sample cognitively unimpaired controls (CU1; N=41). Both groups underwent in-depth neuropsychological assessment of apraxia (Dementia Apraxia Screening Test; DATE and the Cologne Apraxia Screening; KAS). In addition, static PET imaging with [18F]PI-2620 was performed to assess tau pathology in the AD patients. To specifically investigate the association of apraxia with regional tau-pathology, we compared the PET-data from this group with an independent sample of amyloid-negative cognitively intact participants (CU2;N=54) by generation of z-score-deviation maps as well as voxel- based multiple regression analyses.ResultsWe identified significant clusters of tau-aggregation in praxis-related regions (e.g., supramarginal gyrus, angular gyrus, temporal, parietal and occipital regions) that were associated with apraxia. These regions were similar between the two apraxia assessments. No correlations between tau-tracer uptake in primary motor cortical or subcortical brain regions and apraxia were observed.ConclusionsThese results suggest that tau deposition in specific cortical brain regions may induce local neuronal dysfunction leading to a dose-dependent functional decline in praxis performance.

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“…Instruktionen mit Bildern reduzieren den Einfluss der Aphasie [43]. Die Imitation bedeutungsloser Bewegungen ist eine weitgehend sprachunabhängige und deswegen besonders sensitive Untersuchungsmethode bei Patienten mit linkshemisphärischen Läsionen [1], wobei apraktische Störungen auch nach rechtshemisphärischen Läsionen auftreten können [45].…”

Section: Klinische Testung Von Apraxieunclassified

Netzwerke für motorische Kognition

et al. 2017

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Apraxia is an umbrella term for different disorders of higher motor abilities that are not explained by elementary sensorimotor deficits (e. g. paresis or ataxia). Characteristic features of apraxia that are easy to recognize in clinical practice are difficulties in pantomimed or actual use of tools as well as in imitation of meaningless gestures. Apraxia is bilateral, explaining the cognitive motor disorders and occurs frequently (but not exclusively) after left hemispheric lesions, as well as in neurodegenerative diseases, such as corticobasal syndrome and Alzheimer's disease. Apraxic deficits can seriously impair activities of daily living, which is why the appropriate diagnosis is of great relevance. At the functional anatomical level, different cognitive motor skills rely on at least partly different brain networks, namely, a ventral processing pathway for semantic components, such as tool-action associations, a ventro-dorsal pathway for sensorimotor representations of learnt motor acts, as well as a dorso-dorsal pathway for on-line motor control and, probably, imitation of meaningless gestures. While these networks partially overlap with language-relevant regions, more clear cut dissociations are found between apraxia deficits and disorders of spatial attention. In addition to behavioral interventions, noninvasive neuromodulation approaches, as well as human-computer interface assistance systems are a growing focus of interest for the treatment of apraxia.

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Das revidierte Kölner Apraxie-Screening (KAS-R) als diagnostisches Verfahren für Patienten mit rechtshemisphärischem Schlaganfall

Cited by 8 publications

References 3 publications

Limb Apraxias: The Influence of Higher Order Perceptual and Semantic Deficits in Motor Recovery After Stroke

Limb Apraxias: The Influence of Higher Order Perceptual and Semantic Deficits in Motor Recovery After Stroke

Cortical Tau Aggregation Patterns associated with Apraxia in Alzheimer‘s Disease

Netzwerke für motorische Kognition

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