Cortical Tau Aggregation Patterns associated with Apraxia in Alzheimer‘s Disease
Gérard N. Bischof,
Elena Jaeger,
Kathrin Giehl
et al.
Abstract:ObjectivesApraxia is a core feature of Alzheimer’s disease, but the pathomechanism of this characteristic symptom is not well understood. Here, we systematically investigated apraxia profiles in a well-defined group of patients with Alzheimer’s disease (AD; N=32) who additionally underwent PET imaging with the second-generation tau PET tracer [18F]PI-2620. We hypothesized that specific patterns of tau pathology might be related to apraxic deficits.MethodsPatients (N=32) with a biomarker-confirmed diagnosis of … Show more
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