Das Problem der Lebensdauer und seine Beziehungen zu Wachstum und Ernährung

Rubner, Max

doi:10.1515/9783486736380

Cited by 259 publications

(144 citation statements)

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“…Rubner 1908;Pearl 1928). However, it is only during the last decades that the potential mechanisms underlying this link have become a widely studied subject (Bonsall 2006).…”

Section: Introductionmentioning

confidence: 99%

Idle slow as you grow old: longitudinal age-related metabolic decline in a wild passerine

et al. 2009

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Physiological changes due to aging are intensively studied as they have farreaching implications for the mechanistic and evolutionary theories of senescence. In this respect, metabolic rate has been suggested to play a role for the deterioration and damage of cells and tissues with age, partly due to the generation of reactive oxygen species. To mitigate such damage, individuals can be predicted to reduce basal metabolic rate (BMR) with age. This prediction has been verified in humans and some laboratory animals but never in wild animal populations. We analyzed the change in BMR within individuals across years in two wild populations of great tit (Parus major) differing in BMR. Great tits, living under stressful conditions towards the northern limit of their distribution, decreased their BMR as they aged whereas no such decrease was found in a southern population. Thus, we found a clear decline only in the population with the highest BMR levels. This study provides the first evidence of an age-related decline in BMR for a wild homeotherm.

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“…Rubner 1908;Pearl 1928). However, it is only during the last decades that the potential mechanisms underlying this link have become a widely studied subject (Bonsall 2006).…”

Section: Introductionmentioning

confidence: 99%

Idle slow as you grow old: longitudinal age-related metabolic decline in a wild passerine

et al. 2009

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“…Restriction of mobility was associated with a higher growth rate and a higher body weight despite a significant decrease in food intake. Notwithstanding food intake reduction and physical inactivity, mobility restriction still shortened the life span in these female mice, another finding that disputes the rate-of-living hypothesis originally proposed by Rubner et al (19). Also, a major drawback to the study is that the possible effects of stress on longevity due to overcrowding were not addressed.…”

Section: Effects Of Exercise In Female Rats and On Reducedmentioning

confidence: 68%

“…This hypothesis is related to the "rate-of-living" theory of aging, which simply states that life span is inversely proportional to metabolic rate (18,19). A corollary of this hypothesis is that exercise, because of its elevated physical activity, should shorten life span.…”

Section: Metabolic Consideration Of Dietary Restriction and Exercisementioning

confidence: 99%

“…As noted above, early studies utilizing exercise to intervene in aging processes had as their aim to test the "rate-of-living" theories of aging, most notably espoused by Rubner (19) and Pearl (18). Slonaker (21), and later Benedict and Sherman (22), showed that exercised animals had shorter life spans than did sedentary controls, results which supported the "rate-of-living" hypothesis.…”

Section: Dietary Restriction Exercise and Longevitymentioning

confidence: 99%

“…A causal relation between energy metabolism and longevity was first proposed by Rubner (19) in the "rate-of-living" theory of aging. This theory is based on comparative studies in which the life span of a variety of mammals was found inversely related to their metabolic rate (i.e., length of life was determined by the intensity of metabolism).…”

Section: Mechanisms Of Aging As Probed By Dietary Restriction and Exementioning

confidence: 99%

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Effects of dietary restriction and exercise on the age-related pathology of the rat

Ikeno

Bertrand

Herlihy

1997

AGE

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Intervention of the aging process is an effective, experimental means of uncovering the bases of aging. The most efficacious and commonly used intervention used to retard the aging processes is dietary restriction (DR). It increases mean and maximum life spans, delays the appearance, frequency, and severity of many age-related diseases, and more importantly, attenuates much of the physiological decline associated with age. Although the subject of intense research, the mechanism by which DR alters the aging processes is still unknown. Physical exercise is another effective intervention shown to affect aging phenomena, especially when applied in combination with DR. Mild exercise in concert with DR is beneficial, but vigorous exercise coupled with DR could be deleterious. With regard to pathology, exercise generally exerts a salutary influence on age-related diseases, both neoplastic and non-neoplastic, and this effect may contribute to the increase in median life span seen with exercised rats. Exercise coupled with 40% DR was found to suppress the incidence of fatal neoplastic disease compared to the sedentary DR group. Exercise with mild DR suppressed the incidence of multiple fatal disease and chronic nephropathy, and also delayed the occurrence of many age-related lesions compared to the ad libitum (AL) control group. However, these effects may have little bearing on the aging process per se, as maximum life span is only minimally affected. Although not as intensively studied as DR, results from studies that utilize exercise as a research probe, either alone or in combination with DR, have helped to assess the validity of proposed mechanisms for DR and aging itself. Neither the retardation of growth rate nor the increase in physical activity, observed with either exercise or DR, appear to contribute to the anti-aging action of DR. Moreover, results from lifelong exercise studies indicate that the effects of DR do not depend upon changes in energy availability or metabolic rate. The mechanisms involving effects on adiposity or immune function are also inadequate explanations for the action of DR on aging. Of the proposed mechanisms, only one, as postulated by the Oxidative Stress Hypothesis of Aging, tenably accounts for the known effects of DR and exercise on aging.

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Possible Relation Between Optical Activity and Aging

Kühn¹

1959

Advances in Enzymology - And Related Areas of Molecular Biology

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Das Problem der Lebensdauer und seine Beziehungen zu Wachstum und Ernährung

Cited by 259 publications

References 0 publications

Idle slow as you grow old: longitudinal age-related metabolic decline in a wild passerine

Idle slow as you grow old: longitudinal age-related metabolic decline in a wild passerine

Effects of dietary restriction and exercise on the age-related pathology of the rat

Possible Relation Between Optical Activity and Aging

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