Abstract:A cellular automaton is described, which allows a simple simulation of patterns of gastric blood flow distribution. Effects of redistribution, which can be simulated on the basis of the energy requirements of acid secretion and the morphology of the gastric vascular bed, are isomorph to form and site of gastric ulcer in man. Special forms of the 'peptic' lesion as linear ulcers or 'peptic' stenoses of the oesophagus are consistent with the theory of a submucous steal-phenomenon.
“…While the location of gastric borderline lesions has been described by the discrete model mentioned above the resulting pattern of blood flow at the boundaries of the acid-secreting mucosa has been simulated earlier by use of a simple cellular automaton 26 . The model took into account the different metabolic demands of adjacent mucosae (a dimensionless variable varying from 10 to 100), limited influx conditions as a Boolean variable and the preferential direction of submucous arteries (AXIAL or CIRCULAR).…”
Section: Theoretical Background and Development Of The Modelmentioning
confidence: 99%
“…The phenomenology of duodenal ulcers however cannot be understood by acid secretion and wall stress alone. To understand these findings and to demonstrate the influence of an additional variable such as the presence of unbuffered intraluminal acid on the developing pattern in the duodenal wall, we will consider a differential model of intestinal blood flow.Figure 4Output of the cellular automaton as given in 26 . On the right side the corpus mucosa shows a higher metabolic demand compared to the antral side (left).…”
Section: Theoretical Background and Development Of The Modelmentioning
confidence: 99%
“…The left part of the pattern resembles Aschoff’s Reibungsform of gastric ulcer. For details of the model and the underlying program-code see 26 .…”
Section: Theoretical Background and Development Of The Modelmentioning
confidence: 99%
“…Output of the cellular automaton as given in 26 . On the right side the corpus mucosa shows a higher metabolic demand compared to the antral side (left).…”
Section: Theoretical Background and Development Of The Modelmentioning
The structural organization of intestinal blood flow is such as to allow for intramural collateral flow. Redistribution phenomena due to different local metabolic demands may lead to an impaired perfusion of parts of the intestinal wall which will display a characteristic pattern. Based on Ohm’s and Kirchhoff’s laws, a differential analysis of the gastric vascular bed bridges the gap between basic physiological concepts and traditional anatomical, pathological and clinical knowledge. An ulcer of the intestinal wall becomes understandable as a non-occlusive infarct based on a supply/demand conflict in an anisotropic structure as it can be found in the upper and lower gastrointestinal tract of man.
“…While the location of gastric borderline lesions has been described by the discrete model mentioned above the resulting pattern of blood flow at the boundaries of the acid-secreting mucosa has been simulated earlier by use of a simple cellular automaton 26 . The model took into account the different metabolic demands of adjacent mucosae (a dimensionless variable varying from 10 to 100), limited influx conditions as a Boolean variable and the preferential direction of submucous arteries (AXIAL or CIRCULAR).…”
Section: Theoretical Background and Development Of The Modelmentioning
confidence: 99%
“…The phenomenology of duodenal ulcers however cannot be understood by acid secretion and wall stress alone. To understand these findings and to demonstrate the influence of an additional variable such as the presence of unbuffered intraluminal acid on the developing pattern in the duodenal wall, we will consider a differential model of intestinal blood flow.Figure 4Output of the cellular automaton as given in 26 . On the right side the corpus mucosa shows a higher metabolic demand compared to the antral side (left).…”
Section: Theoretical Background and Development Of The Modelmentioning
confidence: 99%
“…The left part of the pattern resembles Aschoff’s Reibungsform of gastric ulcer. For details of the model and the underlying program-code see 26 .…”
Section: Theoretical Background and Development Of The Modelmentioning
confidence: 99%
“…Output of the cellular automaton as given in 26 . On the right side the corpus mucosa shows a higher metabolic demand compared to the antral side (left).…”
Section: Theoretical Background and Development Of The Modelmentioning
The structural organization of intestinal blood flow is such as to allow for intramural collateral flow. Redistribution phenomena due to different local metabolic demands may lead to an impaired perfusion of parts of the intestinal wall which will display a characteristic pattern. Based on Ohm’s and Kirchhoff’s laws, a differential analysis of the gastric vascular bed bridges the gap between basic physiological concepts and traditional anatomical, pathological and clinical knowledge. An ulcer of the intestinal wall becomes understandable as a non-occlusive infarct based on a supply/demand conflict in an anisotropic structure as it can be found in the upper and lower gastrointestinal tract of man.
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