A Differential Approach to Form and Site of Peptic Ulcer

Rau, W.; Hohaus, Christoph; Jessen, E.

doi:10.1038/s41598-019-44893-x

Cited by 6 publications

(6 citation statements)

References 46 publications

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“…Peptic ulcer is a common pathological condition affecting the upper digestive tract of up to 10% of the population worldwide [1]. Typically, it is an acid-induced ulceration of the gastrointestinal mucosa that is often located in the stomach or around the proximal duodenum, and usually extends deeper into the layers of the submucosa or muscularis propria [2, 3]. The aetiology of the disease includes an imbalance between different defensive and inductive factors, such as mucosal barrier; acid, pepsin, and mucous secretion; cellular regeneration; parietal cells; blood flow; and endogenous protective agents such as epidermal growth factors and prostaglandins [4].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Antioxidant Effects of the Proton Pump-Inhibiting Drugs Omeprazole, Esomeprazole, Lansoprazole, Pantoprazole, and Rabeprazole

et al. 2020

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Introduction: Peptic lesions usually develop when there is an imbalance between aggressive drivers and gastro-protective mediators that guard the lining of the gastrointestinal tract. The most crucial of these mediators are antioxidants, whose loss may predispose to oxidative stress, which is believed to be the main aggravator of several diseases including peptic ulcer. Proton pump inhibitors (PPIs) are drugs that are highly effective and widely used for therapeutic management of peptic disorders through inhibition of gastric acid secretion. In spite of this, oxidative damage may continue to be a major issue that can predispose to future lesions. Objective: The present study is designed to explore the possible antioxidant capability of different PPIs, including omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole, in an aim to suggest an agent that, in addition to its acid-suppression properties, can provide antioxidant profit. Methods: The antioxidant activity of different PPIs was evaluated calorimetrically to test the ability of each drug to quench oxygen free radical, using the well-known stable free radical α,α-diphenyl-β-picrylhydrazyl (DPPH), and compared to ascorbic acid (AA; vitamin C). The measurements were performed using a spectrophotometer at 517 nm. Results: All the studied drugs reduced DPPH, but to different extents. However, omeprazole and esomeprazole showed the highest ability to scavenge free radicals (50% inhibitory concentrations [IC 50 s] of the percentage for free radical scavenging activity are 18.7 ± 5.7 and 18.7 ± 5.7, respectively, and the AA equivalents are 83,772 ± 11,887 and 81,732 ± 8,523 mg AA/100 g, respectively). Conversely, lansoprazole, pantoprazole, and rabeprazole might be having no role in this story (IC 50 s of the percentage for free radical scavenging activity are 49.3 ± 3.1, 49 ± 9.4, and 40.7 ± 7.2, respectively, and the AA equivalents are 30,458 ± 3,884, 32,222 ± 10,377, and 37,876 ± 8,816 mg AA/100 g, respectively). Conclusion: Thus, omeprazole and esomeprazole may confer a significant dual action in gastrointestinal protection by providing potent antioxidant properties in addition to their major role as acid-suppression agents. However, further studies are essential to elucidate the mechanism behind the difference between the drugs of the same class.

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Section: Introductionmentioning

confidence: 99%

Comparison of Antioxidant Effects of the Proton Pump-Inhibiting Drugs Omeprazole, Esomeprazole, Lansoprazole, Pantoprazole, and Rabeprazole

et al. 2020

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“…1. Gastric ulcers through Water Immersion Restraint stress (WRS) resemble the gastric mucosa lesions induced by acute invasive factors (trauma or surgery) or by infection (1). This model was wide admitted for the research of stress ulcers (2,3).…”

Section: Resultsmentioning

confidence: 99%

“…This model was wide admitted for the research of stress ulcers (2,3). The pathological basis of stress-induced gastric ulcer is complex and involve multiple factors, such as inflammation and oxidative stress (1). The model is extensively used and is useful for estimating or studying the effects of the new drugs in the healing process of gastric ulcers in laboratory animals.…”

Section: Resultsmentioning

confidence: 99%

Particularities of Experimental Models Used to Induce Gastric Ulcer

Simona

Pelin

Ghiciuc

et al. 2019

ARS Medica Tomitana

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Introduction: Gastric ulcer is one of the most common gastrointestinal diseases, therefore the constant interest for new treatments is due to adverse effects induced by current therapy. The restricted number of in vivo experimental models is a challenge for researchers. Objectives: Identifying the particularities of different types of experimentally induced gastric ulcer in laboratory animals to facilitate their choise for the study of new antiulcer drugs. Material and method: A search in PubMed and Scopus using keywords ( “experimentally” AND “gastric ulcer” AND “rats/mice”) to include experimental studies with the description of local-induced changes. Review articles and in vitro studies were excluded. Results and discussions: Experimental researches on new drugs for gastric ulcer use chemical or surgical methods to induce gastric lesions in rats. Non-steroidal anti-inflammatory drugs (NSAIDs) and acetic acid models to investigate antisecretory and cytoprotective effects; ethanol models evaluate cytoprotective and/or antioxidant effects; pylorus ligature models to evaluate the effects on the secretion of aggressive gastric factors (hydrochloric acid or pepsin). NSAIDs (indomethacin, acetylsalicylic acid or ibuprofen) inhibit cyclooxygenase activity, resulting from reduced mucus and bicarbonate secretion, decreased mucosal blood flow, alteration of microvascular structures, causing epithelial damage Ethanol enhances the proteolytic and hydrolytic action of hydrochloric acid and pepsin; in addition, stimulates the acid secretion and disruptes vascular endothelium. Pylorus ligature determines the accumulation of gastric acid resulting in gastric ulcers due to the autodigestion of the mucosa. Conclusion: The knowledge of the mechanisms to induce experimental gastric ulcers is essential for choosing the model to evaluate new antiulcer agents.

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“…An ulcer is the condition of corrosion in the linings of the stomach and the duodenum. Thus, ulcers in the gastrointestinal tract are subdivided into ulcerative colitis (lower) and peptic ulcers (upper) depending on the location of the infection [28,29]. Peptic ulcers, also known as gastric and duodenal ulcers, can be characterized as submucosal damage of the digestive tract caused by the disruption of the balance between the hostile factors (i.e., gastric acid, Helicobacter pylori, and anti-inflammatory drugs) and protective factors (i.e., mucus, bicarbonate, prostaglandins, and blood flow towards the mucosa) [30].…”

Section: Inflammatory Diseases and Ulcersmentioning

confidence: 99%

Therapeutic Promises of Medicinal Plants in Bangladesh and Their Bioactive Compounds against Ulcers and Inflammatory Diseases

Ahmed

Rabbee

Roy

et al. 2021

Plants

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When functioning properly, the stomach is the center of both physical and mental satisfaction. Gastrointestinal disorders, or malfunctioning of the stomach, due to infections caused by various biological entities and physiochemical abnormalities, are now widespread, with most of the diseases being inflammatory, which, depending on the position and degree of inflammation, have different names such as peptic or gastric ulcers, irritable bowel diseases, ulcerative colitis, and so on. While many synthetic drugs, such as non-steroidal anti-inflammatory drugs, are now extensively used to treat these diseases, their harmful and long-term side effects cannot be ignored. To treat these diseases safely and successfully, different potent medicinal plants and their active components are considered game-changers. In consideration of this, the present review aimed to reveal a general and comprehensive updated overview of the anti-ulcer and anti-inflammatory activities of medicinal plants. To emphasize the efficacy of the medicinal plants, various bioactive compounds from the plant extract, their experimental animal models, and clinical trials are depicted.

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A Differential Approach to Form and Site of Peptic Ulcer

Cited by 6 publications

References 46 publications

Comparison of Antioxidant Effects of the Proton Pump-Inhibiting Drugs Omeprazole, Esomeprazole, Lansoprazole, Pantoprazole, and Rabeprazole

Comparison of Antioxidant Effects of the Proton Pump-Inhibiting Drugs Omeprazole, Esomeprazole, Lansoprazole, Pantoprazole, and Rabeprazole

Particularities of Experimental Models Used to Induce Gastric Ulcer

Therapeutic Promises of Medicinal Plants in Bangladesh and Their Bioactive Compounds against Ulcers and Inflammatory Diseases

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