Das Hoigné-Syndrom

Schreiber, W.; Krieg, Jürgen-Christian

doi:10.1007/s001150170080

Cited by 9 publications

(2 citation statements)

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“…Hoigne’s syndrome is currently considered a pseudoanaphylactic or pseudoallergic reaction following intramuscular and aqueous procaine penicillin administration. This disorder is characterized predominantly by neuropsychiatric alterations including severe psychomotor agitation, as well as alterations of consciousness and seizures [11]. It must be differentiated from authentic anaphylactic shock as a result of penicillin.…”

Section: Discussionmentioning

confidence: 99%

Neurosyphilis presenting with dementia, chronic chorioretinitis and adverse reactions to treatment: a case report

Mehrabian¹,

Raycheva²,

Petrova³

et al. 2009

Cases J

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Neurosyphilis results from infection of the brain, meninges or spinal cord by Treponema pallidum and develops in about 25%-40% of persons who are not treated for syphilis. This article reports a rare case of active neurosyphilis with mild dementia, chronic chorioretinitis, and hearing loss. During the treatment with Penicillin, a rare combination of complications such as Jarisch-Herxheimer and Hoigné reactions were observed.The clinical feature is characterized by a slow progressive cognitive decline and behavior changes for the last 2 years. Neuropsychological examination revealed mild dementia (MMSE = 23) with impaired memory and attention and executive function. Left sided chronic chorioretinitis and hearing loss were documented. High dose intravenous penicillin therapy was complicated by Jarisch-Herxheimer and Hoigne reactions. During the follow up examinations at 6 and 12 months, the clinical signs, neuropsychological examination, and cerebrospinal fluid (CFS) samples showed improvement of dementia, CSF findings, and hydrocephalus.In conclusion, this atypical presentation of neurosyphilis in combination with rare complications of treatment is worthy of attention. Neurosyphilis should be part of the differential diagnosis of each patient showing cognitive deterioration and behaviour disturbances.

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Section: Discussionmentioning

confidence: 99%

Neurosyphilis presenting with dementia, chronic chorioretinitis and adverse reactions to treatment: a case report

Mehrabian¹,

Raycheva²,

Petrova³

et al. 2009

Cases J

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“…In Einzelfällen wurde über eine assoziierte Lungenembolie nach Benzathinpenizillininjektion berichtet. In der psychiatrischen Pharmakotherapie werden -je nach Symptomatik -Sedativa, klassische Neuroleptika, trizyklische Antidepressiva und moderne, atypische Neuroleptika (Olanzapin) eingesetzt, um Spätfolgen zu vermeiden [31].…”

Section: Therapieunclassified

Medical emergencies following dermatological injections and infusions

Dill-Müller

2006

Hautarzt

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Emergency situations following appropriately administered injections and infusions are an uncommon dermatologic problem. Embolia cutis medicamentosa is an uncommon complication following intramuscular injection which leads to infarct-like cutaneous necrosis. It may develop after gluteal injection of corticosteroids, anti-inflammatory agents and antibiotics and has rarely been described following venous sclerotherapy with polidocanol. Hoigné syndrome is a pseudoanaphylactic or pseudoallergic reaction following intramuscular injection of procaine penicillin, with neuropsychiatric problems developing immediately after the injection. Subacute forms following intramuscular or oral administration of structurally-related antibiotics. The intraoperative use of patent blue dye has a 1-2% risk of allergic reactions. The patient must be monitored carefully following injection for the onset the life-threatening immediate reaction. Extravasation of cytostatic agents is a critical iatrogenic problem in oncology with an incidence of up to 6.5%. Every oncologic department should have an understanding of necrotic risk of the various agents and an emergency kit with instructions for immediate steps, also including agent-specific antidotes as available.

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Arzneireaktionen

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Dermatologie Und Venerologie

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Hypersensitivitäts-Syndrom -433 Urtikaria -434 Angioödem -434 Serumkrankheit -435 Bullöse Arzneimittelreaktionen -435 Vasculitis allergica -436 Hautblutungen, Purpura -436 Kumarinnekrose -437 Lichenoide Exantheme -437 Erythema nodosum, nodöse Infiltrate -438 Fixes Arzneimittelexanthem -438 Akne und akneiforme Exantheme durch Arzneimittel und Hormone -439 Halogenoderme -439 Akute generalisierte exanthematische Pustulose (AGEP) -440 Lupus-erythematodes-artige Reaktionen -440 Photosensitivitätsreaktionen -440 Pigmentveränderungen -441 Haarveränderungen -441 Nagelveränderungen -442 Embolia cutis medicamentosa -443 Ekkrine Reaktionen -443 Akrales Erythem -443 Ulzera durch paravasal injizierte Arnzeimittel -444 Hoigné-Syndrom -445 Provokation latenter oder manifester Hauterkrankungen -446 Literatur -446 Makulopapulöse Exantheme Epidemiologie. Makulöse und makulopapulöse Exantheme sind zusammen mit Urtikaria die häufigsten Formen der kutanen unerwünschten Arzneimittelreaktionen. Fast alle häufig verschriebenen Arzneimittel können makulöse Exantheme auslösen, und auch von den weniger häufig verwendeten sind fast ausnahmslos Exantheme als Nebenwirkungen bekannt. Ätiopathogenese. Sie ist bislang nicht geklärt. Eine T-Zellvermittelte Immunreaktion ist offenbar beteiligt.Arzneimittelreaktive T-Zellen wurden sowohl im peripheren Blut als auch in den Hautveränderungen nachgewiesen. Die positive Epikutantestreaktion und der positive Lymphozytenproliferationstest mancher Patienten weisen auf eine immunologische Reaktion oder Mitreaktion hin. Andererseits kommen T-Zell-vermittelte Reaktionen auch durch chemisch inerte Arzneistoffe vor. Es gibt Hinweise auf eine direkte T-Zell-Stimulierung durch das Arzneimittel, eine

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Das Hoigné-Syndrom

Cited by 9 publications

References 0 publications

Neurosyphilis presenting with dementia, chronic chorioretinitis and adverse reactions to treatment: a case report

Neurosyphilis presenting with dementia, chronic chorioretinitis and adverse reactions to treatment: a case report

Medical emergencies following dermatological injections and infusions

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