Das Flavoprotein Dodecin als redoxaktive Sonde für Elektronentransfer durch DNA

Redox cofactors mediate many enzymatic processes and are increasingly employed in biomedical and energy applications. Exploring the influence of external magnetic fields on redox cofactor chemistry can enhance our understanding of magnetic‐field‐sensitive biological processes and allow the application of magnetic fields to modulate redox reactions involving cofactors. Through a combination of experiments and modeling, we investigate the influence of magnetic fields on electrochemical reactions in redox cofactor solutions. By employing flavin mononucleotide (FMN) cofactor as a model system, we characterize magnetically induced changes in Faradaic currents. We find that radical pair intermediates have negligible influence on current increases in FMN solution upon application of a magnetic field. The dominant mechanism underlying the observed current increases is the magneto‐hydrodynamic effect. We extend our analyses to other diffusion‐limited electrochemical reactions of redox cofactor solutions and arrive at similar conclusions, highlighting the opportunity to use this framework in redox cofactor chemistry.

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Influence of Magnetic Fields on Electrochemical Reactions of Redox Cofactor Solutions

Park

Koehler

Varnavides

et al. 2021

Angewandte Chemie

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show abstract

Influence of Magnetic Fields on Electrochemical Reactions of Redox Cofactor Solutions

et al. 2021

View full text Add to dashboard Cite

Redox cofactors mediate many enzymatic processes and are increasingly employed in biomedical and energy applications.E xploring the influence of external magnetic fields on redox cofactor chemistry can enhance our understanding of magnetic-field-sensitive biological processes and allowt he application of magnetic fields to modulate redox reactions involving cofactors.T hrough ac ombination of experiments and modeling,w ei nvestigate the influence of magnetic fields on electrochemical reactions in redox cofactor solutions.Byemployingflavin mononucleotide (FMN) cofactor as am odel system, we characterize magnetically induced changes in Faradaic currents.W ef ind that radical pair intermediates have negligible influence on current increases in FMN solution upon application of am agnetic field. The dominant mechanism underlying the observed current increases is the magneto-hydrodynamic effect. We extend our analyses to other diffusion-limited electrochemical reactions of redox cofactor solutions and arrive at similar conclusions,h ighlighting the opportunity to use this framework in redox cofactor chemistry.

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Das Flavoprotein Dodecin als redoxaktive Sonde für Elektronentransfer durch DNA

Cited by 2 publications

References 38 publications

Influence of Magnetic Fields on Electrochemical Reactions of Redox Cofactor Solutions

Influence of Magnetic Fields on Electrochemical Reactions of Redox Cofactor Solutions

Influence of Magnetic Fields on Electrochemical Reactions of Redox Cofactor Solutions

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