Das Auftreten eines azetylcholinartigen Stoffes im Herzvenenblut von Warmblütern bei Reizung der Nervi vagi

Allosterism at Muscarinic Receptors: Ligands and Mechanisms

“…However n can be increased to 6 without affecting potency [117]. This contrasts to the preferred n > 6 carbon spacer in the bisammonio alkane series related to W84 (7). The properties of asymmetrical analogs of the bispyridinium oximes and the (2,6-dichlorobenzyl)ether derivatives (R ≠ R') will be considered in later sections.…”

“…This was the first definition of receptor subtypes even though Dale, at that time, was not familiar with the receptor concept. It took the brilliant work of Loewi and Navratil [6] and Feldberg and Krayer [7] to establish the chemical basis of neurotransmission and identify ACh as the endogenous neurotransmitter at nicotinic and muscarinic receptors.…”

Chemical mediators in the central nervous system

“…Loewi termed this hypothetical chemical substance 'Vagustoff' and later identified it as acetylcholine. Release of a similar substance in the mammalian heart was demonstrated by Feldberg & Krayer (1933). Dale, Feldberg & V gt (1936) later reported the release of acetylcholine at the neuromuscular junction following stimulation of motor nerves to skeletal muscle.…”

How Does Cholinergic Activation Slow Down Sinus Node Automaticity?“Diastolic Voltage Oscillations” vs. “Calcium Clock” Mechanisms

“…6 Loewi’s discovery was eventually confirmed in warm blooded animals with more highly organized nervous systems as Rylant in 1927 extended Loewi’s frog experiments to rabbits 7 and Feldberg and Krayer in 1933 to cats and dogs. 8 …”