How Does Cholinergic Activation Slow Down Sinus Node Automaticity?“Diastolic Voltage Oscillations” vs. “Calcium Clock” Mechanisms

Karagueuzian, Hrayr S.

doi:10.1111/j.1540-8167.2010.01866.x

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Current Personalized Drugs Targeting Proteoform1

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2024

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“… Proteoform Effect Ref. Eye Pupil opening muscles α 1 Contract (delate pupils) ( 118 ) Pupil sphincter M 3 Contract (miosis) ( 119 ) Ciliary muscle β 2 Slack (farsightedness) ( 118 ) M3 Contract (shortsighted) ( 120 ) Heart Sinus node β 1 Increased autorhythmicity and accelerated heart rate ( 121 ) M2 Decreased autorhythmicity and slowed heart rate ( 122 ) Room knot β 1 Speed up conduction ( 123 ) M 2 Slow down conduction ( 124 ) Conduction system β 1 Speed up conduction ( 125 ) M 2 Slow down conduction ( 126 ) Myocardium β 1 Increased contraction ( 127 ) M 2 Contraction weakened ( 128 ) Vascular smooth muscle Skin, mucosa α 1 , α 2 Contract ( 129 ) …”

Section: Current Personalized Drugs Targeting Proteoformmentioning

confidence: 99%